<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div class=""><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class=""><div class=""><div class=""><div class=""><div class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><p class="MsoNormal"><span class="" style="font-size: 10pt; font-family: ArialMT, serif;">The discovery of novel classes of antibiotics for </span><i class=""><span class="" style="font-size: 10pt; font-family: Arial, sans-serif;">Enterobacteriaceae, A. baumannii </span></i><span class="" style="font-size: 10pt; font-family: ArialMT, serif;">and </span><i class=""><span class="" style="font-size: 10pt; font-family: Arial, sans-serif;">P. aeruginosa </span></i><span class="" style="font-size: 10pt; font-family: ArialMT, serif;">(the most critically classed pathogens on the WHO priority list), is particularly </span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">hindered</span><span class="" style="font-size: 10pt; font-family: ArialMT, serif;"> by their efficient and promiscuous xenobiotic efflux pumps that prevent the efficacy of new chemical</span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;"> inhibitors</span><span class="" style="font-size: 10pt; font-family: ArialMT, serif;">.</span><span class="" style="font-size: 10pt; font-family: ArialMT, serif;"> </span><span class="" style="font-family: ArialMT, serif; font-size: 10pt;">The upregulation of these pumps in clinical strains also results in resistance to current antibiotics. It is therefore clear that developing inhibitors to these efflux systems, as well as enriching our knowledge of the basic biology of these pumps will be a major step forward in breaking the xenobiotic defence system of these bacteria.</span></p><p class="MsoNormal"><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">A </span><span class="" style="font-size: 10pt; font-family: ArialMT, serif;">postdoc position is</span><span class="" style="font-size: 10pt; font-family: ArialMT, serif;"> available </span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">in the group</span><span class="" style="font-size: 10pt; font-family: ArialMT, serif;"> of Prof. </span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">Achilleas Frangakis, </span><span class="" style="font-size: 10pt; font-family: ArialMT, serif;">at the </span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">Goethe </span><span class="" style="font-size: 10pt; font-family: ArialMT, serif;">University </span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">Frankfurt in Germany, in collaboration with partners of the EFFORT consortium, to study </span><span class="" style="font-size: 10pt; font-family: ArialMT, serif;">efflux pump</span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">s using single-particle microscopy and cryo-electron tomography.<o:p class=""></o:p></span></p><p class="MsoNormal"><span class="" style="font-size: 10pt; font-family: ArialMT, serif;">The mission of the candidate will be to </span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">conduct structural and biophysical characterization </span><span class="" style="font-size: 10pt; font-family: ArialMT, serif;"><b class="">of the RND efflux pumps from pathogens,</b> </span><span class="" style="font-size: 10pt; font-family: ArialMT, serif;">by using single-particle cryo-EM</span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">. Additionally, efflux pumps will be characterised in their native state using cryo-electron tomography</span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">.</span></p><p class="MsoNormal"><span class="" style="font-size: 10pt; font-family: ArialMT, serif;">Diligent, independent and committed candidate</span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">s</span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;"> </span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">are encouraged to apply</span><span class="" style="font-size: 10pt; font-family: ArialMT, serif;">. Candidates should h</span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">old a </span><span class="" style="font-size: 10pt; font-family: ArialMT, serif;">Ph.D. thesis in molecular biology, biochemistry, structural biology or similar disciplines</span><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">.</span></p><p class="MsoNormal"><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">Please contact <a href="mailto:achilleas.frangakis@biophysik.org" class="">achilleas.frangakis@biophysik.org</a> for more information.<o:p class=""></o:p></span></p><p class="MsoNormal"><span lang="EN-US" class="" style="font-size: 10pt; font-family: ArialMT, serif;">Website (in German): <a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.gesundheitsforschung-2Dbmbf.de_de_efflux-2Dpumpen-2Dinhibitoren-2Dzur-2Duberwindung-2Dantimikrobieller-2Dresistenzen-2Deffort-2D10533.php&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=KQU8jIMtOVAl5iZTSSimWUSHOAo1orWqiQdLSxMmiII&s=qIUSTOKmo0y0qgM-IbBTFigg7JYPlljveiKp08dp8fo&e=" class="">https://www.gesundheitsforschung-bmbf.de/de/efflux-pumpen-inhibitoren-zur-uberwindung-antimikrobieller-resistenzen-effort-10533.php</a>).</span></p><div class=""><br class=""></div></div></div></div></div></div></div></div><br class=""><div class=""><div dir="auto" class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div dir="auto" class="" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;"><div class="">—</div><div class="">Prof. Dr. Achilleas Frangakis<br class="">Goethe University Frankfurt<br class="">Buchmann institute for Molecular Life Sciences (BMLS)</div><div class="">Institute of Biophysics<br class="">Max-von-Laue-Str. 15, D-60438 Tel: +49 69 798 46462<br class="">Germany Fax: +49 69 798 46465<br class=""><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__www.bmls.de_Electron-5FMicroscopy_aboutus.html&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=KQU8jIMtOVAl5iZTSSimWUSHOAo1orWqiQdLSxMmiII&s=3UmW-Aqx5DMdfMukbgHANzBiYIVzw2IJtcv4mNTa_a4&e=" class="">https://www.bmls.de/Electron_Microscopy/aboutus.html</a></div><div class=""><a href="https://urldefense.proofpoint.com/v2/url?u=http-3A__www.biophysik.org_frangakis_&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=KQU8jIMtOVAl5iZTSSimWUSHOAo1orWqiQdLSxMmiII&s=jZBTKlq6K89jwVEip1MY8ftXG3cGqWXQgRvSADFKZ_s&e=" class="">http://www.biophysik.org/frangakis/</a> <br class=""><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__fcem.uni-2Dfrankfurt.de_&d=DwMFaQ&c=-35OiAkTchMrZOngvJPOeA&r=L7-zyQ-04fFCMRqzLIOnx7H0exGZHwIQe_wMPuY600I&m=KQU8jIMtOVAl5iZTSSimWUSHOAo1orWqiQdLSxMmiII&s=ynH9qhxWG78wuo9BjBbc_aBId57gaF8nt7DM7KybCVs&e=" class="">https://fcem.uni-frankfurt.de/</a></div><div class=""><br class=""></div><div class=""><br class=""></div></div></div></div></body></html>