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<p class="MsoPlainText">Dear all,<o:p></o:p></p>
<p class="MsoPlainText"><o:p> </o:p></p>
<p class="MsoPlainText">Please join us for TWO upcoming online webinars:<o:p></o:p></p>
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<p class="MsoNormal"><b>NEXT WEEK - Wednesday, May 19</b>, <i>Turn on the lights in cryo-FIB tomography – Introducing our new integrated (in-chamber) fluorescent light microscope for Aquilos 2 cryo-FIB<o:p></o:p></i></p>
<p class="MsoNormal"><b><span style="color:black;background:white">Alexander Rigort, Thermo Fisher Scientific</span><span style="background:white"><o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="color:black;background:white">Cellular cryo-electron tomography is a high-resolution technique that enables imaging of the molecular machinery of a cell at close-to-native conditions. To render cells suitable for tomographic
imaging, electron-transparent regions, named cryo-lamellae, must first be prepared with a cryo-focused ion beam (cryo-FIB) microscope. These cryo-lamellae are essentially snapshots of functional cellular environments preserved in a fully hydrated state and
embedded in non-crystalline vitreous ice. The process of lamella preparation has now been further developed and automated. To enable correlative imaging of vitrified samples, a new integrated light microscope has been added to the cryo-FIB microscope. Now,
the correlation of signals between two imaging modalities - light and electron microscopy - within one system becomes possible. The built-in fluorescence module facilitates localization of lamella sites and makes it possible to verify whether already milled
lamellae contain fluorescent targets. In this webinar we will share with you the latest developments and advances.</span><b><span style="background:white"><o:p></o:p></span></b></p>
<p class="MsoPlainText"><o:p> </o:p></p>
<p class="MsoNormal"><b>Wednesday, June 24 </b><i>Structural Oncology - Fighting Cancer with Cryo-EM<o:p></o:p></i></p>
<p class="MsoNormal"><b><span style="color:black;background:white">Deb Kelly, Pennsylvania State University</span><o:p></o:p></b></p>
<p class="MsoPlainText">Currently, there are insufficient therapies to fully eradicate human cancer or predict who it will strike. Rational-drug design based on structural insights is an under-utilized yet powerful tool. An exciting new direction for the cryo-Electron
Microscopy (EM) field involves the structure determination of medically-relevant macromolecules for therapeutic purposes. Developing fresh tools to evaluate native protein assemblies can advance this bold initiative. In this webinar Dr. Deborah Kelly from
Pennsylvania state university will present structural insights for a prime culprit implicated in causing aggressive cancers – the protein factor p53. Importantly, p53 is the most altered gene in human cancer and it is mutated in about half of all malignancies.
The National Cancer Institute has determined that individuals having defects in p53 will likely face life-threatening consequences related to cancer induction and metastasis. Thanks to advances in materials research, sample preparation, and direct electron
detectors, her group has determined the first cryo-EM structures for p53 isolated from human cancer cells. Pairing our structural findings with biochemical and cellular studies, provides additional fuel to understand differences in p53 function. Equally important,
improving our knowledge of tumor suppressors gone awry may lead to new interventions based on structural oncology approaches.<o:p></o:p></p>
<p class="MsoPlainText"><o:p> </o:p></p>
<p class="MsoPlainText">All sessions will have live Q&A to ask your questions.<o:p></o:p></p>
<p class="MsoPlainText"><o:p> </o:p></p>
<p class="MsoPlainText">REGISTER FOR REMAINING WEBINARS on Labroots.com: <a href="https://urldefense.com/v3/__https://www.labroots.com/ms/virtual-event/thermo-fisher-scientific-electron-microscopy-webinars/agenda__;!!Mih3wA!WPZoyvnHTUr23n4kddB1yNLZ90LpYKlw1pqWHAK2c5Usfaq56Yz9N6jSt9-eZkpktA$">
https://www.labroots.com/ms/virtual-event/thermo-fisher-scientific-electron-microscopy-webinars/agenda</a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Best regards,<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Jeff<o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:13.5pt;color:black">____________________________________________________________________<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-family:"Arial",sans-serif;color:black">Jeffrey Lengyel, Ph.D.</span></b><span style="font-family:"Arial",sans-serif;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Principal Scientist, Electron Microscopy Life Sciences<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Materials & Structural Analysis<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Thermo Fisher Scientific<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">5350 NE Dawson Creek Drive | Hillsboro, OR 97124<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black">Phone 503 560 9184 <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial",sans-serif;color:black"><a href="mailto:Jeffrey.Lengyel@thermofisher.com">Jeffrey.Lengyel@thermofisher.com</a><o:p></o:p></span></p>
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