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<span style="font-family:Calibri,Helvetica,sans-serif">Structural EM community - </span>
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<span style="font-family:Calibri,Helvetica,sans-serif">The Akey laboratory in the Department of Physiology and Biophysics at Boston University
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<span style="font-family:Calibri,Helvetica,sans-serif">School of Medicine has an open position for a post-doctoral associate in cryo-electron
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<span style="font-family:Calibri,Helvetica,sans-serif">microscopy that is funded by an NIH grant for 3 years. Research in the group is focused on</span></p>
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<span style="font-family:Calibri,Helvetica,sans-serif">the structure and function of protein translocation machines, including the bacterial
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<span style="font-family:Calibri,Helvetica,sans-serif">ribosome-SecY channel complex and the Nuclear Pore Complex. In these studies, 3D single</span></p>
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<span style="font-family:Calibri,Helvetica,sans-serif">particle and tomographic, sub-volume averaging methods are used to elucidate the structure
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<span style="font-family:Calibri,Helvetica,sans-serif">of </span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt"> </span></span><span style="font-family:Calibri,Helvetica,sans-serif">these
remarkable translocation machines: For an overview see:</span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt"> </span></span></p>
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<span style="font-family:Calibri,Helvetica,sans-serif"></span><span style="font-family:Calibri,Helvetica,sans-serif"><span style="font-size:11.0pt;font-family:Calibri;color:blue"><a href="https://urldefense.com/v3/__https://www.bumc.bu.edu/phys-biophys/profile/christopher-akey/__;!!Mih3wA!U98Ds4FQwCusxV_7SPYWg_3yO6o732vwP60Z26g-tiqzmovkGmMPw77a6aIt5-IPjA$" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" data-linkindex="0">https://www.bumc.bu.edu/phys-biophys/profile/christopher-akey/</a></span><span style="font-size:11.0pt;font-family:Calibri">).</span><br>
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<span style="font-family:Calibri,Helvetica,sans-serif">Our research is highly collaborative and once suitable samples are prepared at our cryo-EM
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<span style="font-family:Calibri,Helvetica,sans-serif">facility, data are collected remotely at National cryo-EM beamlines for analysis on our groups'
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<span style="font-family:Calibri,Helvetica,sans-serif">in-house gpu-cpu cluster.</span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt"> </span></span></p>
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<span style="font-size:11.0pt;font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt"> </span></span></p>
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<span style="font-family:Calibri,Helvetica,sans-serif">The successful candidate will have a Ph.D.</span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt">
</span></span><span style="font-family:Calibri,Helvetica,sans-serif">with expertise in Biophysics, Computational or
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<span style="font-family:Calibri,Helvetica,sans-serif">Structural Biology; prior experience in cryo-EM, while a plus, is not required.</span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt">
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<span style="font-family:Calibri,Helvetica,sans-serif">To apply, please send a cover letter, CV and contact information for 3 references to:
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<span style="font-family:Calibri,Helvetica,sans-serif"></span><span style="font-size:11.0pt;font-family:Arial"><span style="color:blue;font-family:Calibri,Helvetica,sans-serif;font-size:12pt">cakey@bu.edu</span></span><span style="font-family:Calibri,Helvetica,sans-serif">.</span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt"> </span></span></p>
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<span style="font-family:Calibri,Helvetica,sans-serif">Recent publications:</span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt"> </span></span></p>
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<i><span style="font-family:Calibri,Helvetica,sans-serif">NPC consortium:</span></i><span style="font-family:Calibri,Helvetica,sans-serif">
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<span style="font-family:Calibri,Helvetica,sans-serif">Kim SJ, Fernandez-Martinez J, Nudelman I, Shi Y, et al. (2018). Integrative structure and
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<span style="font-family:Calibri,Helvetica,sans-serif">functional anatomy of a Nuclear Pore Complex. Nature. 555:475-482.
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<span style="font-family:Calibri,Helvetica,sans-serif">doi: 10.1038/nature26003. Epub 2018 Mar 14.
</span><span style="font-family:Calibri,Helvetica,sans-serif">PMID</span><span style="font-family:Calibri,Helvetica,sans-serif">: 29539637</span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt">
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<i><span style="font-family:Calibri,Helvetica,sans-serif">Akey research group:</span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt"> </span></span></i></p>
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<span style="font-family:calibri,helvetica,sans-serif;background-color:rgba(0,0,0,0)">Cheng, T.C., Akey, I.V., Yuan, S., Yu, Z., Ludtke, S.J. and
</span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:calibri,helvetica,sans-serif;font-size:12pt;background-color:rgba(0,0,0,0)">Akey, C.W</span></span><span style="font-family:calibri,helvetica,sans-serif;background-color:rgba(0,0,0,0)">.
(2017). A near <br>
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<span style="font-family:calibri,helvetica,sans-serif;background-color:rgba(0,0,0,0)">atomic
</span><span style="font-family:Calibri,Helvetica,sans-serif"></span><span style="font-family:calibri,helvetica,sans-serif;background-color:rgba(0,0,0,0)">structure of the Dark apoptosome provides insight into assembly and activation.</span></p>
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<span style="font-family:calibri,helvetica,sans-serif;background-color:rgba(0,0,0,0)"></span><span style="font-family:Calibri,Helvetica,sans-serif"></span><span style="font-family:calibri,helvetica,sans-serif;background-color:rgba(0,0,0,0)">Structure 25:40-52.
doi: 10.1016/j.str.2016.11.002. </span><span style="font-family:calibri,helvetica,sans-serif;background-color:rgba(0,0,0,0)">PMID</span><span style="font-family:calibri,helvetica,sans-serif;background-color:rgba(0,0,0,0)">: 27916517</span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:calibri,helvetica,sans-serif;font-size:12pt;background-color:rgba(0,0,0,0)">
</span><span style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt"></span></span><span style="font-family:calibri,helvetica,sans-serif;background-color:rgba(0,0,0,0)"><br>
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<span style="font-family:calibri,helvetica,sans-serif;background-color:rgba(0,0,0,0)">Cheng, T.C., Hong, C., Akey, I.V., Yuan, S. and
</span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:calibri,helvetica,sans-serif;font-size:12pt;background-color:rgba(0,0,0,0)">Akey, C.W</span></span><span style="font-family:calibri,helvetica,sans-serif;background-color:rgba(0,0,0,0)">.
(2016). A near atomic structure of <br>
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<span style="font-family:calibri,helvetica,sans-serif;background-color:rgba(0,0,0,0)">the active human apoptosome. Elife. Oct 4;5. pii: e1</span><span style="font-family:Calibri,Helvetica,sans-serif">7755. doi: 10.7554/eLife.17755.
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<span style="font-family:Calibri,Helvetica,sans-serif">PMID</span><span style="font-family:Calibri,Helvetica,sans-serif">: 27697150</span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt">
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<span style="font-family:Calibri,Helvetica,sans-serif">Park, E., Ménétret, J. F., Gumbart, J.C., Ludtke, S.J., Li, W., Whynot, A., Rapoport, T. A., and
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<span style="font-family:Calibri,Helvetica,sans-serif">Akey, C. W. (2014). Structure of the SecY channel during initiation of protein translocation.
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<span style="font-family:Calibri,Helvetica,sans-serif">Nature 506, 102-106. </span>
<span style="font-family:Calibri,Helvetica,sans-serif">PMID</span><span style="font-family:Calibri,Helvetica,sans-serif">: 24153188</span><span style="font-size:11.0pt;font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif;font-size:12pt">
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<span style="font-size:11.0pt;font-family:Calibri">Pubmed:<span style="color:blue"><a href="https://urldefense.com/v3/__https://pubmed.ncbi.nlm.nih.gov/?term=akey*cw&sort=date&size=100__;Kw!!Mih3wA!U98Ds4FQwCusxV_7SPYWg_3yO6o732vwP60Z26g-tiqzmovkGmMPw77a6aLREz-j9A$" target="_blank" rel="noopener noreferrer" data-auth="NotApplicable" data-linkindex="1"> https://pubmed.ncbi.nlm.nih.gov/?term=akey+cw&sort=date&size=100</a></span></span></p>
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<p style="margin:0in 0in 0.0001pt;font-size:12pt;font-family:"Times New Roman""><span style="font-size:11.0pt"> <span style="mso-spacerun:yes">
</span> <span style="font-size: 12pt; font-family: Calibri, Helvetica, sans-serif;">
Structural Electron Microscopy</span></span><span style="font-size: 12pt; font-family: Calibri, Helvetica, sans-serif;"> Group</span><span style="font-size:11.0pt"><br>
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</span><span style="font-size: 11pt; font-family: Calibri, Helvetica, sans-serif;">Christopher W. Akey, Professor</span><span style="font-size:11.0pt"><br>
</span><span style="font-size: 11pt; font-family: Calibri, Helvetica, sans-serif;">Dept. of Physiology and Biophysics</span><span style="font-size:11.0pt"><br>
</span><span style="font-size: 11pt; font-family: Calibri, Helvetica, sans-serif;">Boston Univ. School of Medicine</span><span style="font-size:11.0pt"><br>
</span><span style="font-size: 11pt; font-family: Calibri, Helvetica, sans-serif;">700 Albany St.</span><span style="font-size:11.0pt"><br>
</span><span style="font-size: 11pt; font-family: Calibri, Helvetica, sans-serif;">Boston, Mass. 02118-2526</span><span style="font-size:11.0pt"><br>
</span><span style="font-size: 9pt;"></span><span style="font-size:11.0pt"><br>
</span><span style="font-size: 11pt; font-family: Calibri, Helvetica, sans-serif;">office: 617 358 4451 lab: 8-4450 Computer room: 8-8458</span><span style="font-size:11.0pt"><br>
<span style="font-family: Calibri, Helvetica, sans-serif;"> </span></span><span style="font-size: 11pt; font-family: Calibri, Helvetica, sans-serif;">cakey@bu.edu</span><span style="font-size:11.0pt"><br>
<span style="color: blue; font-family: Calibri, Helvetica, sans-serif;"><a href="https://urldefense.com/v3/__https://www.bumc.bu.edu/phys-biophys/profile/christopher-akey/__;!!Mih3wA!U98Ds4FQwCusxV_7SPYWg_3yO6o732vwP60Z26g-tiqzmovkGmMPw77a6aIt5-IPjA$">https://www.bumc.bu.edu/phys-biophys/profile/christopher-akey/</a></span><span style="color:blue"><o:p><span style="font-family: Calibri, Helvetica, sans-serif;"> </span></o:p></span></span></p>
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