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<span style="font-size: 12pt; line-height: normal;">Dear colleagues, </span><o:p><span style="font-size: 12pt; line-height: normal;"> </span></o:p></p>
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<span style="font-size: 12pt; line-height: normal;">A postdoctoral research associate position in structural biology is immediately available in my group at Department of Biochemistry & Molecular Biology, Michigan State University.</span></p>
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<span style="font-size: 12pt; line-height: normal;">By deploying approaches of structural biology (primarily x-ray crystallography), biochemistry, biophysics, and cell biology, my group has been working on multiple macromolecules important in biomedicine and
biotechnology, including the ZIP metal transporters (</span><span style="font-size: 12pt; line-height: normal;"><i style="line-height: normal;">Nat Commun</i></span><span style="font-size: 12pt; line-height: normal;">. 2016, 7:11979;
</span><span style="font-size: 12pt; line-height: normal;"><i style="line-height: normal;">Sci Adv</i></span><span style="font-size: 12pt; line-height: normal;">. 2017, 3:e1700344;
</span><span style="font-size: 12pt; line-height: normal;"><i style="line-height: normal;">Cell Rep</i></span><span style="font-size: 12pt; line-height: normal;">. 2020, 31:107582), the PIPK lipid kinases (</span><span style="font-size: 12pt; line-height: normal;"><i style="line-height: normal;">Sci
Adv</i></span><span style="font-size: 12pt; line-height: normal;">. 2016, 2:e1600925;
</span><span style="font-size: 12pt; line-height: normal;"><i style="line-height: normal;">Biochem J</i></span><span style="font-size: 12pt; line-height: normal;">. 2018, 475:2257), and the LarA racemases/epimerases (</span><span style="font-size: 12pt; line-height: normal;"><i style="line-height: normal;">Science</i></span><span style="font-size: 12pt; line-height: normal;">.
2015, 349:66; </span><span style="font-size: 12pt; line-height: normal;"><i style="line-height: normal;">PNAS</i></span><span style="font-size: 12pt; line-height: normal;">. 2017, 114:9074). Single-particle cryo-EM will be applied to the suitable systems which
have been identified in these projects. The overarching goal is to clarify the working mechanisms at atomic resolution. For more information, please visit
</span><a href="https://urldefense.com/v3/__https://bmb.natsci.msu.edu/faculty/jian-hu/__;!!Mih3wA!XP7FHsQI0OUZ037ALeTTBl54PJkLGRwKyUwOjDUWQx5qbHfLZqPM78CsvDvfGbFRsw$"><span style="font-size: 12pt; line-height: normal;">https://bmb.natsci.msu.edu/faculty/jian-hu/</span></a><span style="font-size: 12pt; line-height: normal;">.</span><o:p><span style="font-size: 12pt; line-height: normal;"> </span></o:p></p>
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<span style="font-size: 12pt; line-height: normal;">The recently opened and fully functional MSU cryo-EM facilities have a 200 kV Talos Arctica microscope equipped with a Falcon 3 direct detection detector, phase plate, and autoloader. The facilities provide
state-of-the-art computational resources, training for students and postdocs, and opportunities for collaboration with the core faculty members. More information can be found at
</span><a href="https://urldefense.com/v3/__https://cryo-em.natsci.msu.edu/equipment/cryo-em-facility/__;!!Mih3wA!XP7FHsQI0OUZ037ALeTTBl54PJkLGRwKyUwOjDUWQx5qbHfLZqPM78CsvDsmm7bOkw$"><span style="font-size: 12pt; line-height: normal;">https://cryo-em.natsci.msu.edu/equipment/cryo-em-facility/</span></a><span style="font-size: 12pt; line-height: normal;">. Additional
microscopes complementary to the facilities are available in The Center for Advanced Microscopy (</span><a href="https://urldefense.com/v3/__https://cryo-em.natsci.msu.edu/equipment/center-for-advanced-microscopy/__;!!Mih3wA!XP7FHsQI0OUZ037ALeTTBl54PJkLGRwKyUwOjDUWQx5qbHfLZqPM78CsvDuubqHebA$"><span style="font-size: 12pt; line-height: normal;">https://cryo-em.natsci.msu.edu/equipment/center-for-advanced-microscopy/</span></a><span style="font-size: 12pt; line-height: normal;">).</span></p>
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<span style="font-size: 12pt; line-height: normal;">Successful candidate is expected to be highly self-motivated with Ph.D. in structural biology, biochemistry, biophysics, or related fields. Hands-on experience and a proven track record in single-particle
cryo-EM is required. Experience in large scale eukaryotic protein expression/purification, ideally using mammalian cell expression system, is desirable. Experience in membrane protein study is a plus but not a must. This NIH funding supported position will
be initially available for one year, with possible renewal up to additional four years based on mutual satisfaction.</span><o:p><span style="font-size: 12pt; line-height: normal;"> </span></o:p></p>
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<span style="font-size: 12pt; line-height: normal;">Interested individuals should submit a cover letter, CV, and the names and the contact information of three referees to Dr. Jian Hu by email:
</span><a href="mailto:hujian1@msu.edu"><span style="font-size: 12pt; line-height: normal;">hujian1@msu.edu</span></a><span style="font-size: 12pt; line-height: normal;">. Review of application will start immediately, and the position will be open until filled.</span><o:p><span style="font-size: 12pt; line-height: normal;"> </span></o:p></p>
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<div>~~~~~~</div>
<div>Jian Hu, PhD</div>
<div>Associate Professor,</div>
<div>Department of Biochemistry and Molecular Biology &</div>
<div>Department of Chemistry,</div>
<div>Michigan State University,</div>
<div>603 Wilson Rd., East Lansing, MI 48824</div>
<a href="https://urldefense.com/v3/__https://bmb.natsci.msu.edu/faculty/jian-hu/__;!!Mih3wA!XP7FHsQI0OUZ037ALeTTBl54PJkLGRwKyUwOjDUWQx5qbHfLZqPM78CsvDvfGbFRsw$" class="OWAAutoLink">https://bmb.natsci.msu.edu/faculty/jian-hu/</a><br>
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