<div dir="ltr"><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Dear 3DEM / CCPEM,</span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">We are happy to announce the general availability of </span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">cryoSPARC v3</span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"> and </span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">cryoSPARC Live</span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">! </span><a href="https://urldefense.com/v3/__https://guide.cryosparc.com/setup-configuration-and-management/how-to-download-install-and-configure__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q6WDfXBiQ$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">Click here to download and install.</span></a></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><a href="https://urldefense.com/v3/__https://cryosparc.com/__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q5oEDYvZA$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">CryoSPARC</span></a><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"> is used today by scientists at hundreds of academic institutions and many industry labs to power and accelerate single-particle cryo-EM workflows. Thanks to tremendous support and feedback from cryo-EM scientists, </span><a href="https://urldefense.com/v3/__https://structura.bio/*team__;Iw!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q6pwlzklA$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">our growing team</span></a><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"> has been working to rapidly develop cryoSPARC and we have an ambitious roadmap ahead. Our overall aim is to help expand the frontiers of SPA and realize a vision of cryo-EM as a robust, high-throughput, scalable tool that is central to enabling new science and biological advances across basic research and drug discovery.</span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">To that end, we are very proud to announce that </span><a href="https://urldefense.com/v3/__https://cryosparc.com/live__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q42sYrd2g$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">cryoSPARC Live</span></a><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"> is available for all - and is free of charge for </span><a href="https://urldefense.com/v3/__https://guide.cryosparc.com/licensing__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q53Nn6DpQ$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">non-profit academic research</span></a><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">.</span></p><a href="https://urldefense.com/v3/__https://cryosparc.com/live__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q42sYrd2g$"><img src="cid:ii_klvac7a80" alt="cryoSPARC-Live-only-550.gif" style="margin-right: 0px;"></a><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;color:rgb(0,0,0);font-family:Arial;font-size:11pt;white-space:pre-wrap;vertical-align:baseline">Many cryo-EM scientists have imagined a future where 3D structures can be solved right at the microscope and where processing results can provide real-time feedback into data collection. </span><span style="background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;color:rgb(0,0,0);font-family:Arial;font-size:11pt;white-space:pre-wrap;font-weight:700;vertical-align:baseline">CryoSPARC Live</span><span style="background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;color:rgb(0,0,0);font-family:Arial;font-size:11pt;white-space:pre-wrap;vertical-align:baseline"> enables that future today - and has been in production use at dozens of major cryo-EM facilities and industry labs since its initial private release in May 2019.</span><a href="https://urldefense.com/v3/__https://cryosparc.com/live*testimonials__;Iw!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q6dqtZvbg$" target="_blank" style="background-color:transparent;white-space:pre-wrap;text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline"> </span><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline">Read what users have to say.</span></a><br><span style="background-color:transparent;color:rgb(0,0,0);font-family:Arial;font-size:11pt;white-space:pre-wrap;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline"></span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"></span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"></span></p><ul style="margin-top:0px;margin-bottom:0px"><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:0pt"><a href="https://urldefense.com/v3/__https://guide.cryosparc.com/live/about-cryosparc-live__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q77HXflAw$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline">Live performs real-time preprocessing, particle picking, streaming 2D classification and 3D refinement faster than data collection</span></a><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">. This means 2D classes and 3D refined structures update every few minutes as new particle images are collected.</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">It is the </span><a href="https://urldefense.com/v3/__https://guide.cryosparc.com/live/performance-metrics__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q6YEH1xmg$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline">fastest</span></a><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">, simplest way for all users to process new cryo-EM data, real-time or not. Outputs can be used directly in cryoSPARC or other tools for advanced processing.</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">On our development roadmap, Live is the platform that will enable full processing automation and data-driven decision making during collection.</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">In cryoSPARC v3, Live has been redesigned, fine-tuned and optimized based on extensive feedback. Our team is very happy to contribute a mature, engineered, commercial product to the community to help accelerate cryo-EM science.</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:12pt"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">Stay tuned for an upcoming webinar in April!</span></p></li></ul><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">In addition to building Live, we are continuously improving cryoSPARC algorithms, features, workflow and performance.</span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><a href="https://urldefense.com/v3/__https://cryosparc.com/updates__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q5IcUiNFA$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">CryoSPARC v3</span></a><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"> is faster than ever. On our </span><a href="https://urldefense.com/v3/__https://guide.cryosparc.com/setup-configuration-and-management/hardware-and-system-requirements*example-hardware-systems__;Iw!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q7GY2kmKA$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">test workstation</span></a><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">:</span></p><ul style="margin-top:0px;margin-bottom:0px"><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:0pt"><span style="font-size:11pt;color:rgb(255,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">4.5 minutes</span><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline"> for 2D classification of 250K particles into 50 classes on a </span><span style="font-size:11pt;background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">single GPU</span><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline"> (box size 256; EMPIAR-10288)</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;color:rgb(255,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">8.2 minutes</span><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline"> for 2D classification of 250K particles into 100 classes on a </span><span style="font-size:11pt;background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">single GPU </span><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">(box size 256; EMPIAR-10288)</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;color:rgb(255,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">7.5 minutes</span><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline"> for 3D refinement of 105K particles to 3.0Å resolution on a </span><span style="font-size:11pt;background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">single GPU</span><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline"> (box size 360; EMPIAR-10028)</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;color:rgb(255,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">650 movies per hour per GPU</span><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline"> Live processing (K2-counting, TIFF, 40 frames)</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><span style="font-size:11pt;color:rgb(255,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">420 movies per hour per GPU</span><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline"> Live processing (K3-counting, TIFF, 40 frames)</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:12pt"><span style="font-size:11pt;color:rgb(255,0,0);background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">303 movies per hour per GPU</span><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline"> Live processing (Falcon 4, EER 2x usampled, 40 frames)</span></p></li></ul><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">And includes new methods advances:</span></p><ul style="margin-top:0px;margin-bottom:0px"><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:0pt"><a href="https://urldefense.com/v3/__https://www.nature.com/articles/s41592-020-00990-8__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q43tgAYpA$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline">Non-uniform Refinement (Nature Methods 2020)</span></a><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">, used widely to improve map quality for membrane proteins. Updated and improved in v3, and used extensively for SARS-CoV-2 spike protein structures</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:0pt"><a href="https://urldefense.com/v3/__https://doi.org/10.1016/j.jsb.2021.107702__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q4A_nfgnA$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline">3D Variability Analysis (JSB 2021)</span></a><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline">, enables high-resolution continuous conformational changes to be resolved even in small proteins, used notably for several recent studies of GPCR conformational landscapes</span></p></li><li dir="ltr" style="margin-left:15px;list-style-type:disc;font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><p dir="ltr" style="line-height:1.38;margin-top:0pt;margin-bottom:12pt"><a href="https://urldefense.com/v3/__https://guide.cryosparc.com/processing-data/all-job-types-in-cryosparc/helical-reconstruction-beta__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q79_OiyDQ$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline">Helical refinement tools (new in v3)</span></a><span style="font-size:11pt;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline"> including filament picking and symmetry search methods</span></p></li></ul><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">As part of the v3 launch, we have created a new </span><a href="https://urldefense.com/v3/__https://guide.cryosparc.com/__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q4U9EwGyQ$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">cryoSPARC Guide</span></a><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">. It is perfect for beginners as well as experts, with extensive videos, tutorials, case studies, and fully searchable details about each job type.</span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">The </span><a href="https://urldefense.com/v3/__https://discuss.cryosparc.com/__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q6E6u8hNw$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">cryoSPARC Discussion Forum</span></a><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"> has grown to be a vibrant, helpful and friendly community with 1000+ active users and 100+ new topics per month. All questions are welcome and fruitful discussions with community members and our team are common.</span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Lastly, </span><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-weight:700;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><font color="#9900ff">our team is hiring</font></span><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><font color="#9900ff">!</font><font color="#0000ff"> </font></span><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Join our mission-driven, fast-moving organization and help us develop new methods and tools that can power both fundamental academic life science research and ambitious drug discovery projects searching for life-changing medicines. We are looking for methods developers, software engineers, cryo-EM scientists with expertise in computational tools, and high-performance computing experts. Work at the frontier of structural biology and see your work used by thousands of scientists daily. Please reach out to </span><a href="mailto:careers@structura.bio" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">careers@structura.bio</span></a><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">.</span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><br></span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Thank you!</span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><a href="https://urldefense.com/v3/__https://structura.bio/*team__;Iw!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q6pwlzklA$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">The cryoSPARC Team</span></a></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Structura Biotechnology Inc.</span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-style:italic;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap"><br></span></p><p dir="ltr" style="line-height:1.38;margin-top:12pt;margin-bottom:12pt"><span style="font-size:11pt;font-family:Arial;color:rgb(0,0,0);background-color:transparent;font-style:italic;font-variant-numeric:normal;font-variant-east-asian:normal;vertical-align:baseline;white-space:pre-wrap">Note: CryoSPARC v3.0 was made available in December 2020, and as of this announcement, v3.1.0 is available with several stability and performance enhancements. 
</span><span style="background-color:transparent;font-variant-numeric:normal;font-variant-east-asian:normal;font-size:11pt;font-family:Arial;color:rgb(0,0,0);font-style:italic;vertical-align:baseline;white-space:pre-wrap">For more information, please see: </span><a href="https://urldefense.com/v3/__https://cryosparc.com/updates__;!!Mih3wA!VCoTVOe3ZOofudB5dMFErJpMSJFXAslt1l_liwDqFJtnrAnJjd8UA-W80q5IcUiNFA$" target="_blank" style="text-decoration-line:none"><span style="font-size:11pt;font-family:Arial;background-color:transparent;font-style:italic;font-variant-numeric:normal;font-variant-east-asian:normal;text-decoration-line:underline;vertical-align:baseline;white-space:pre-wrap">https://cryosparc.com/updates</span></a></p></div>