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<p class="MsoNormal">Hi everyone,<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">We worked with our antibody business to productize the antibody tool scFv16 that can be used for the stabilization of GPCR/G-protein complexes:
<a href="https://urldefense.com/v3/__https://www.thermofisher.com/antibody/product/GPCR-G-protein-complex-stabilizing-scFv-Antibody-clone-scFv16-Recombinant-Monoclonal/703976__;!!Mih3wA!XCxzcQ9YFcV5F_BFra4FceRi2KICK_IVrXGQgUi8_V_keIQ_MVpM-FifliqBaoT0Yg$">
https://www.thermofisher.com/antibody/product/GPCR-G-protein-complex-stabilizing-scFv-Antibody-clone-scFv16-Recombinant-Monoclonal/703976</a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">The scFv16 is license-free and amenable to a variety (if not all) of G-protein subfamilies (e.g. Gi, Gs, etc). For those of you old enough to remember the intractability of active GPCR complexes, here’s a rapidly growing list of PDB depositions
using scFv16: <a href="https://urldefense.com/v3/__https://bit.ly/3brPIDt__;!!Mih3wA!XCxzcQ9YFcV5F_BFra4FceRi2KICK_IVrXGQgUi8_V_keIQ_MVpM-Fiflio_B4Zk8A$">https://bit.ly/3brPIDt</a>. Please do reach out if you have any questions regarding scFv16 or GPCR cryo-EM in general.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Cheers<o:p></o:p></p>
<p class="MsoNormal">Mazdak<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b>Mazdak Radjainia, PhD</b> | Staff Scientist Cryo-EM Pharma<span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal">Materials and Structural Analysis<span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal">Thermo Fisher Scientific <span style="font-size:12.0pt;font-family:"Times New Roman",serif">
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL">Achtseweg Noord 5, 5651 GG Eindhoven</span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="NL">The Netherlands</span><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal">+31 610585016<span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal"> <span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal"><b>Interested in <a href="https://urldefense.com/v3/__https://www.thermofisher.com/us/en/home/global/forms/industrial/gpcr-cryo-em-and-drug-design.html__;!!Mih3wA!XCxzcQ9YFcV5F_BFra4FceRi2KICK_IVrXGQgUi8_V_keIQ_MVpM-FifliojSX4vPA$">
<span style="color:blue">GPCR Cryo-EM & Drug Design</span></a>?</b><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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