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<p class="MsoNormal"><span style="font-size:11.0pt">Dear Colleagues,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:black">The M&M 2021 paper submission deadline has been extended a full week to allow for greater flexibility and more submission completions.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:black"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:black">The new deadline is <b>Thursday, February 25 at 11:59pm ET</b>. The deadline <b><u>WILL NOT</u></b> be extended after this date.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:black"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:black">Remember, even if you can only present virtually, you still need to submit your paper by the deadline to be included in the meeting! During the submission process, there is an option to choose
whether you can preset In-Person or Virtually.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">We would like to bring to your attention a few symposia of interest at the upcoming M&M 2020.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">B01 - 3D Structures: From Macromolecular Assemblies to Whole Cells (3DEM FIG).</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Organizers: Melanie Ohi, Teresa Ruiz, Cheri Hampton and William Rice.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Structure and function of macromolecular complexes in vitro and in vivo<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Single particle cryo-electron microscopy<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Cryo-electron tomography<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">B02 - Cryo-electron Tomography: Present Capabilities and Future Potential<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Organizers: Grant Jensen, Yi-Wei Chang, Danielle Grotjahn and Matt Swulius.<b><o:p></o:p></b></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Cryo-ET allows large macromolecular assemblies to be visualized within cells in a near-native state
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• The range of targets that can be analyzed by cryo-ET is rapidly expanding to both larger and smaller
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Sub-tomogram averaging methods can result in high-resolution structures
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.1pt;text-indent:-7.1pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Many technical advances in instrumentation, methods, and software are dramatically expanding both the power and applicability of
the method <o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">B04 - Michael Rossmann Memorial Symposium<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Organizers: S. Saif Hasan and Terje Dokland.<b><o:p></o:p></b></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Historical perspectives and current developments in the field of high- resolution cryo-EM
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Hybrid structural approaches to study macromolecular complexes
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Assembly and architecture of plant, animal, and bacterial viruses
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• In-situ structural investigations of viral infection and assembly
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Structural biology of proteins involved in metabolism, immunity and pathogenesis
<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">B06 - Multi-Modal Multi-Dimensional Microscopy<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Organizers: James Fitzpatrick, Xiao-Ying Yu, Si Chenand Ben Giepmans.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Multi-Modal Microscopy, Volume EM, CLEM
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• X-Ray Imaging & Analysis<br>
• Analytical Spectroscopy / SIMS <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Instrument hardware development<br>
• Cryogenic sample handling / transfer • Artificial Intelligence based Image <o:p>
</o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Analysis, Big Data Management
<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">B07 - Challenges and Advances in Electron Microscopy Research and Diagnosis of Diseases in Humans, Plants and Animals (FIG associated)<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Organizers: Claudia Lopez, Marcela Redigolo, Ru-Ching Hsia and Han Chen.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.1pt;text-indent:-7.1pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Enhancement of sample preparation workflow for EM analysis of complex tissue for diagnosis or research
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.1pt;text-indent:-7.1pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Application of advanced or innovative EM techniques to study host-pathogen interactions, virulence factors and ultrastructural
changes <o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.1pt;text-indent:-7.1pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Ultrastructural characterization of diseases including the use of organoids, xenografts and animal models
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.1pt;text-indent:-7.1pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Novel approaches and applications for correlative or hybrid microscopy
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.1pt;text-indent:-7.1pt"><b><span style="font-family:"Times New Roman",serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">B08 - Cryo-EM in Drug Discovery<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Organizers: Leah Frye, Giovanna Scapin and Christel Verboven<b><o:p></o:p></b></span></p>
<p class="MsoNormal" style="margin-left:7.1pt;text-indent:-7.1pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Cryo-EM in structure-based drug discovery
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.1pt;text-indent:-7.1pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Cryo-EM in optimization of potency and selectivity
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.1pt;text-indent:-7.1pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Use of cryo-EM to address classical ADMET issues such as hERG inhibition
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.1pt;text-indent:-7.1pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Rapid and efficient determination of cryo- EM structures for drug discovery
<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.1pt;text-indent:-7.1pt"><b><span style="font-family:"Times New Roman",serif"><o:p> </o:p></span></b></p>
<p class="MsoNormal"><b><span style="font-size:10.5pt;font-family:"Arial",sans-serif">B10 - Cryo-EM at local, regional, and national cryo-EM centers<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Organizers: Claudia Lopez, Elizabeth Wright and Clint Potter<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.1pt;text-indent:-7.1pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Sample preparation: screening optimization
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Hardware and software upgrades to optimize data collection<br>
• On the fly data processing. When to stop data collection? <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">• Best practices in a cryoEM facility<br>
• How to best store, analyze, and share your data<br>
• Data processing: what are we missing? <o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:7.1pt;text-indent:-7.1pt"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">There are also interesting short courses Sunday before the meeting and tutorials during the meeting, check it out.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><a href="https://urldefense.com/v3/__https://www.microscopy.org/MandM/2021/meetings/MM2021_CallforPapers.pdf__;!!Mih3wA!V4i6V6bw-kRcwC0bxOFoL9_l49W4tAtdwm1Ql1CTQzQ7mQZdRKeb_GYirPufFox-3w$">https://www.microscopy.org/MandM/2021/meetings/MM2021_CallforPapers.pdf</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">This is a great educational and networking meeting for the entire microscopy community. Students can benefit from a reduced registration fee ($50.00), as well as Post-doctoral
researchers ($195.00) and both will have ample opportunities to receive awards either before the meeting (make sure to check the corresponding box during submission) or during the poster session (for students). For more information go to:<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><a href="https://urldefense.com/v3/__https://www.microscopy.org/MandM/2021/__;!!Mih3wA!V4i6V6bw-kRcwC0bxOFoL9_l49W4tAtdwm1Ql1CTQzQ7mQZdRKeb_GYirPvaSPWz1g$">https://www.microscopy.org/MandM/2021/</a><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">We look forward to seeing many of you at the meeting.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Sincerely,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif">Melanie, Teresa, Cheri and Bill</span><o:p></o:p></p>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
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