<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><meta http-equiv="Content-Type" content="text/html; charset=utf-8" class=""><div style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><meta http-equiv="Content-Type" content="text/html; charset=utf-8" class=""><div style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><meta http-equiv="Content-Type" content="text/html; charset=us-ascii" class=""><div style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div class="">EMDataResource is launching a new Model Challenge today. Please consider participating!</div><div class=""><br class=""></div><div class="">Details: <a href="https://urldefense.com/v3/__https://challenges.emdataresource.org/?q=2021-model-challenge__;!!Mih3wA!UnV7kM9Pnv5frdAd11fUO5xUuIgrCvYl37osxfQzkQLEs_nhQv5Zmtzx5WV8iXWX7Q$" class="">https://challenges.emdataresource.org/?q=2021-model-challenge</a></div><div class="">Registration: <a href="https://urldefense.com/v3/__https://challenges.emdataresource.org/?q=2021-registration__;!!Mih3wA!UnV7kM9Pnv5frdAd11fUO5xUuIgrCvYl37osxfQzkQLEs_nhQv5Zmtzx5WUF5sj6bQ$" class="">https://challenges.emdataresource.org/?q=2021-registration</a> </div><div class=""><br class=""></div><div class=""><span style="color: rgb(33, 37, 41); font-family: -apple-system, system-ui, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"; font-size: 2rem; orphans: 2; widows: 2; background-color: rgb(255, 255, 255);" class="">Announcing the 2021 Ligand Model Challenge</span></div><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 1rem; font-family: -apple-system, system-ui, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"; font-size: 16px; font-variant-ligatures: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); text-decoration-thickness: initial;" class=""><span style="box-sizing: border-box;" class="">February 1, 2021</span>: Our next model challenge launches today: the <a href="https://urldefense.com/v3/__https://challenges.emdataresource.org/?q=2021-model-challenge__;!!Mih3wA!UnV7kM9Pnv5frdAd11fUO5xUuIgrCvYl37osxfQzkQLEs_nhQv5Zmtzx5WV8iXWX7Q$" target="_blank" style="box-sizing: border-box; text-decoration: none; background-color: transparent;" class="">2021 EMDataResource Ligand Model Challenge</a>. The task for modeler teams in this round is to <em style="box-sizing: border-box;" class="">optimize</em> reference models against selected target maps containing protein or protein+RNA, ligands, ions and solvent (1.9-2.5 Å resolution range).</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 1rem; font-family: -apple-system, system-ui, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"; font-size: 16px; font-variant-ligatures: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); text-decoration-thickness: initial;" class="">The three targets are β-Galactosidase (1.8 Å), SARS-CoV-2 Polymerase/remdesivir (2.5 Å), and SARS-CoV-2 ORF3a putative ion channel in nano disc (2.1 Å). Evaluation/model comparison in this round will strongly focus on the ligands and their local environment, and will include additional ligand-specific assessments.</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 1rem; font-family: -apple-system, system-ui, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"; font-size: 16px; font-variant-ligatures: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); text-decoration-thickness: initial;" class="">The deadline for submission of completed models is <span style="box-sizing: border-box;" class="">March 15 </span><span style="box-sizing: border-box;" class="">(3 PM US Eastern)</span>. All interested in participating should fill out the <a href="https://urldefense.com/v3/__https://challenges.emdataresource.org/?q=2021-registration__;!!Mih3wA!UnV7kM9Pnv5frdAd11fUO5xUuIgrCvYl37osxfQzkQLEs_nhQv5Zmtzx5WUF5sj6bQ$" style="box-sizing: border-box; text-decoration: none; background-color: transparent;" class="">registration form</a>.</p><p style="box-sizing: border-box; margin-top: 0px; margin-bottom: 1rem; font-family: -apple-system, system-ui, "Segoe UI", Roboto, "Helvetica Neue", Arial, sans-serif, "Apple Color Emoji", "Segoe UI Emoji", "Segoe UI Symbol", "Noto Color Emoji"; font-size: 16px; font-variant-ligatures: normal; orphans: 2; widows: 2; background-color: rgb(255, 255, 255); text-decoration-thickness: initial;" class="">In preparation for the evaluation phase of the Challenge, we welcome recommendations from the structural biology community regarding ligand-specific evaluation tools. Please send suggestions to <a href="mailto:challenges@emdataresource.org" style="box-sizing: border-box; text-decoration: none; background-color: transparent;" class="">challenges@emdataresource.org</a>.</p></div></div></div></body></html>