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-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">Dear Researchers, </span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt;
font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
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text-decoration: none;"><span style="font-size: 11pt; color:
black;"> </span></p>
<p class="xxmsoplaintext" style="margin: 0in; font-size: 12pt;
font-family: "Times New Roman", serif; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
normal; orphans: auto; text-align: start; text-indent: 0px;
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word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none;"><span
style="font-size: 11pt; font-family: Calibri, sans-serif; color:
black;">The<span class="apple-converted-space"> </span></span><span
style="font-size: 11pt; font-family: Calibri, sans-serif;"><a href="https://urldefense.com/v3/__https://www.bnl.gov/cryo-em/__;!!Mih3wA!XdkX3SjOnK1XuOPEx1KNt75Nnp65AsdqCI6oEsSA54TJAIiRstDRaZsI7RqUJwgocg$" title="https://www.bnl.gov/cryo-em/" style="color: rgb(5, 99,
193); text-decoration: underline;">Laboratory<span
class="apple-converted-space"><span style="color: rgb(5, 99,
193); text-decoration: none;"> </span></span>for<span
class="apple-converted-space"><span style="color: rgb(5, 99,
193); text-decoration: none;"> </span></span>BioMolecular
Structure (LBMS)</a><span class="apple-converted-space"><span
style="color: black;"> </span></span><span style="color:
black;">at Brookhaven National Laboratory<span
class="apple-converted-space"> </span>is now accepting
general research<span class="apple-converted-space"> </span>proposals
through an<span class="apple-converted-space"> </span>open<span
class="apple-converted-space"> </span>proposal<span
class="apple-converted-space"> </span>process for the July –
December (2021-2) cycle. The deadline<span
class="apple-converted-space"> </span>is </span><b><span
style="color: red;">Monday, March 15, 2021 at 11:59 pm New
York time</span></b><span style="color: black;">. </span></span></p>
<p class="xxmsoplaintext" style="margin: 0in; font-size: 12pt;
font-family: "Times New Roman", serif; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
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normal; orphans: auto; text-align: start; text-indent: 0px;
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word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none;"><span
style="font-size: 11pt; font-family: Calibri, sans-serif; color:
black;"> </span></p>
<p class="xxmsoplaintext" style="margin: 0in; font-size: 12pt;
font-family: "Times New Roman", serif; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
normal; orphans: auto; text-align: start; text-indent: 0px;
text-transform: none; white-space: normal; widows: auto;
word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none;"><span
style="font-size: 11pt; font-family: Calibri, sans-serif; color:
black;">This new, state-of-the-art research center offers
scientists access to<span class="apple-converted-space"> </span></span><span
style="font-size: 11pt; font-family: Calibri, sans-serif;"><a href="https://urldefense.com/v3/__https://www.bnl.gov/cryo-em/instrumentation.php__;!!Mih3wA!XdkX3SjOnK1XuOPEx1KNt75Nnp65AsdqCI6oEsSA54TJAIiRstDRaZsI7Rpe1EyewQ$" title="https://www.bnl.gov/cryo-em/instrumentation.php" style="color: rgb(5, 99, 193); text-decoration: underline;">advanced
cryo-electron microscopes</a><span
class="apple-converted-space"><span style="color: black;"> </span></span><span
style="color: black;">(cryo-EMs)<span
class="apple-converted-space"> </span>for<span
class="apple-converted-space"> </span>single particle
analysis of proteins and macromolecular complexes, as well as
cryo-electron tomography (cryo-ET) of cells and tissues.<span
class="apple-converted-space"> </span></span></span></p>
<p class="xxmsoplaintext" style="margin: 0in; font-size: 12pt;
font-family: "Times New Roman", serif; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
normal; orphans: auto; text-align: start; text-indent: 0px;
text-transform: none; white-space: normal; widows: auto;
word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none;"><span
class="apple-converted-space"><span style="font-size: 11pt;
font-family: Calibri, sans-serif; color: black;"> </span></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt;
font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">LBMS operates in two 6-month cycles and all electron
microscope (EM) time is requested through the web-based<span
class="apple-converted-space"> </span></span><span
style="font-size: 11pt;"><a href="https://urldefense.com/v3/__https://pass.bnl.gov/__;!!Mih3wA!XdkX3SjOnK1XuOPEx1KNt75Nnp65AsdqCI6oEsSA54TJAIiRstDRaZsI7RpRJxLGoQ$" title="https://pass.bnl.gov/" style="color: rgb(5, 99, 193);
text-decoration: underline;">Proposal<span
class="apple-converted-space"><span style="color: rgb(5, 99,
193); text-decoration: none;"> </span></span>Allocation,
Safety, and Scheduling System (PASS)</a><span
class="apple-converted-space"><span style="color: black;"> </span></span><span
style="color: black;">system. There are a number of<span
class="apple-converted-space"> </span>modes of access<span
class="apple-converted-space"> </span>for<span
class="apple-converted-space"> </span>cryo-EMs at LBMS
including General User, Rapid Access, and Block Allocation
Groups<span class="apple-converted-space"> </span>that all
follow a common life cycle that involves the following steps:<span
class="apple-converted-space"> </span>proposal<span
class="apple-converted-space"> </span>submission,
feasibility evaluation, peer-review, allocation of EM time,
scheduling, carrying out the work, and reporting the results
and publications.<span class="Apple-converted-space"> </span></span></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt;
font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;"> </span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt;
font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">To create a new proposal, you need to identify the type
of<span class="apple-converted-space"> </span>proposal, the
technique, and the microscope that fits your needs. <span
class="apple-converted-space"> </span>For<span
class="apple-converted-space"> </span>more details, see the<span
class="apple-converted-space"> </span></span><span
style="font-size: 11pt;"><a href="https://urldefense.com/v3/__https://www.bnl.gov/cryo-em/userguide/__;!!Mih3wA!XdkX3SjOnK1XuOPEx1KNt75Nnp65AsdqCI6oEsSA54TJAIiRstDRaZsI7RpW8AN16w$" style="color:
rgb(5, 99, 193); text-decoration: underline;">LBMS User Guide</a><span
style="color: black;">.<span class="Apple-converted-space"> </span></span><b>If
you already have an active proposal, you must submit an EM
time request (ETR) against that proposal for every cycle that
you want EM time through the web-based <a href="https://urldefense.com/v3/__https://pass.bnl.gov/__;!!Mih3wA!XdkX3SjOnK1XuOPEx1KNt75Nnp65AsdqCI6oEsSA54TJAIiRstDRaZsI7RpRJxLGoQ$" target="_blank" title="https://pass.bnl.gov/" style="color: rgb(5, 99, 193);
text-decoration: underline;"><span style="color: windowtext;
border: 1pt none windowtext; padding: 0in;">Proposal
Allocation, Safety, and Scheduling System</span></a> (PASS)
system</b>.</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt;
font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;"> </span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt;
font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">If you feel you may need help during the submission
process, please create your<span class="apple-converted-space"> </span>proposal<span
class="apple-converted-space"> </span>as early as possible.
Please note the<span class="apple-converted-space"> </span></span><span
style="font-size: 11pt;"><a href="https://urldefense.com/v3/__https://www.bnl.gov/ps/users/administration.php__;!!Mih3wA!XdkX3SjOnK1XuOPEx1KNt75Nnp65AsdqCI6oEsSA54TJAIiRstDRaZsI7Rq42eYvVA$" style="color: rgb(5, 99, 193); text-decoration: underline;">User
Services Office</a><span class="apple-converted-space"><span
style="color: black;"> </span></span><span style="color:
black;">will be available until 5:00 pm that day. </span></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt;
font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;"> </span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt;
font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">For<span class="apple-converted-space"> </span>instructions
on how to submit<span class="apple-converted-space"> </span>proposals,
see the<span class="apple-converted-space"> </span></span><span
style="font-size: 11pt;"><a href="https://urldefense.com/v3/__https://www.bnl.gov/cryo-em/userguide/__;!!Mih3wA!XdkX3SjOnK1XuOPEx1KNt75Nnp65AsdqCI6oEsSA54TJAIiRstDRaZsI7RpW8AN16w$" title="https://www.bnl.gov/cryo-em/userguide/" style="color:
rgb(5, 99, 193); text-decoration: underline;">LBMS User Guide</a><span
style="color: black;">. </span><span style="color: rgb(32, 32,
32);">For<span class="apple-converted-space"> </span>questions
regarding the LBMS facility, please contact Liguo Wang at<span
class="apple-converted-space"> </span></span><a
href="mailto:lbms-em@bnl.gov" title="mailto:lbms-em@bnl.gov"
style="color: rgb(5, 99, 193); text-decoration: underline;">lbms-em@bnl.gov</a><span
style="color: rgb(32, 32, 32);">.</span></span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt;
font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;"> </span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt;
font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">We look<span class="apple-converted-space"> </span>forward
to working with you during these exciting early years of LBMS
operations!</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt;
font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;"><br>
</span></p>
<p class="MsoNormal" style="margin: 0in; font-size: 12pt;
font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
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text-decoration: none;"><br>
<span style="font-size: 11pt; color: black;">
</span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-ascii-font-family:Calibri;
mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:black">Laboratory
for BioMolecular Structure (LBMS)</span><span
style="mso-ascii-font-family:
Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:black"></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-ascii-font-family:Calibri;
mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:black">Brookhaven
National Laboratory</span><span
style="mso-ascii-font-family:Calibri;
mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:black"></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-ascii-font-family:Calibri;
mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:black">Building
745</span><span
style="mso-ascii-font-family:Calibri;mso-hansi-font-family:
Calibri;mso-bidi-font-family:Calibri;color:black"></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-ascii-font-family:Calibri;
mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:black">P.O.
Box 5000</span><span
style="mso-ascii-font-family:Calibri;mso-hansi-font-family:
Calibri;mso-bidi-font-family:Calibri;color:black"></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-ascii-font-family:Calibri;
mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:black">Upton,
NY 11973</span><span
style="mso-ascii-font-family:Calibri;mso-hansi-font-family:
Calibri;mso-bidi-font-family:Calibri;color:black"></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-ascii-font-family:Calibri;
mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:black">Email:<span
class="apple-converted-space"> </span></span><a
href="mailto:lbms-em@bnl.gov"><span
style="font-size:11.0pt;mso-ascii-font-family:
Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#0563C1">lbms-em@bnl.gov</span></a><span
style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:
Calibri;color:black"></span></p>
<p class="MsoNormal"><span
style="font-size:11.0pt;mso-ascii-font-family:Calibri;
mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#202020">Website:<span
class="apple-converted-space"> </span></span><a href="https://urldefense.com/v3/__https://www.bnl.gov/cryo-em/__;!!Mih3wA!XdkX3SjOnK1XuOPEx1KNt75Nnp65AsdqCI6oEsSA54TJAIiRstDRaZsI7RqUJwgocg$"><span
style="font-size:11.0pt;mso-ascii-font-family:
Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:Calibri;color:#0563C1">https://www.bnl.gov/cryo-em/</span></a><span
style="mso-ascii-font-family:Calibri;mso-hansi-font-family:Calibri;mso-bidi-font-family:
Calibri;color:black"></span></p>
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text-decoration: none;"><span style="font-size: 11pt; color:
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