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<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">Dear Colleagues,</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman""> </span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">The deadline for paper submission for Microscopy & Microanalysis M&M2021 that will be held in Pittsburgh, PA from August 1-5 2021, is
<b style="mso-bidi-font-weight:normal">Thursday Feb. 18, 11:59 PM</b> US Pacific. Check the instructions, submissions are easier this year and paper format simpler than in earlier years. We look forward to reading your abstracts. Here is the link for the submission
website:</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman""> </span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman""><a href="https://urldefense.com/v3/__https://www.abstractscorecard.com/cfp/submit/login.asp?EventKey=WLEZBHLZ__;!!Mih3wA!V8F7GNtV38kEVihVTUq1jKqs0CEe7ijZge6qPXgdQi1JNYwOjqKiS5C88XcBSYU6mQ$">https://www.abstractscorecard.com/cfp/submit/login.asp?EventKey=WLEZBHLZ</a></span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman""> </span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">The meeting is currently scheduled as an
<i style="mso-bidi-font-style:normal">in person</i> meeting. However, depending on the COVID-19 conditions it might shift to a
<i style="mso-bidi-font-style:
normal">virtual</i> meeting. MSA and MAS Leadership will keep us up to date on the developments. Please state your presentation preference (<i style="mso-bidi-font-style:normal">in-person
</i>or <i style="mso-bidi-font-style:
normal">fully virtual</i>) during the submission process.</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman""> </span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">We would like to bring to your attention a few symposia of interest at the upcoming M&M 2020.
</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman""> </span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<b style="mso-bidi-font-weight:normal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">B01 - 3D Structures: From Macromolecular Assemblies to Whole Cells (3DEM FIG).</span></b><span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">
</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">Organizers: Melanie Ohi, Teresa Ruiz, Cheri Hampton and William Rice.</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Structure and function of macromolecular complexes in vitro and in vivo</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Single particle cryo-electron microscopy</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Cryo-electron tomography</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman""> </span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<b style="mso-bidi-font-weight:normal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">B02 - Cryo-electron Tomography: Present Capabilities and Future Potential</span></b></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">Organizers: Grant Jensen, Yi-Wei Chang, Danielle Grotjahn and Matt Swulius.</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Cryo-ET allows large macromolecular assemblies to be visualized within cells in a near-native state
</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• The range of targets that can be analyzed by cryo-ET is rapidly expanding to both larger and smaller
</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Sub-tomogram averaging methods can result in high-resolution structures
</span></p>
<p style="text-indent: -7.1pt; margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">• Many technical advances in instrumentation, methods, and software are dramatically expanding both the power and applicability of the method
</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<b style="mso-bidi-font-weight:normal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman""> </span></b></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<b style="mso-bidi-font-weight:normal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">B04 - Michael Rossmann Memorial Symposium</span></b></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">Organizers: S. Saif Hasan and Terje Dokland.</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Historical perspectives and current developments in the field of high- resolution cryo-EM
</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Hybrid structural approaches to study macromolecular complexes
</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Assembly and architecture of plant, animal, and bacterial viruses
</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• In-situ structural investigations of viral infection and assembly
</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Structural biology of proteins involved in metabolism, immunity and pathogenesis
</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<b style="mso-bidi-font-weight:normal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman""> </span></b></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<b style="mso-bidi-font-weight:normal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">B06 - Multi-Modal Multi-Dimensional Microscopy</span></b></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">Organizers: James Fitzpatrick, Xiao-Ying Yu, Si Chenand Ben Giepmans.</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Multi-Modal Microscopy, Volume EM, CLEM
</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• X-Ray Imaging & Analysis<br>
• Analytical Spectroscopy / SIMS </span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Instrument hardware development<br>
• Cryogenic sample handling / transfer • Artificial Intelligence based Image </span>
</p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Analysis, Big Data Management
</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<b style="mso-bidi-font-weight:normal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman""> </span></b></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<b style="mso-bidi-font-weight:normal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">B07 - Challenges and Advances in Electron Microscopy Research and Diagnosis of Diseases in Humans, Plants and Animals
(FIG associated)</span></b></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">Organizers: Claudia Lopez, Marcela Redigolo, Ru-Ching Hsia and Han Chen.</span></p>
<p style="text-indent: -7.1pt; margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">• Enhancement of sample preparation workflow for EM analysis of complex tissue for diagnosis or research
</span></p>
<p style="text-indent: -7.1pt; margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">• Application of advanced or innovative EM techniques to study host-pathogen interactions, virulence factors and ultrastructural changes
</span></p>
<p style="text-indent: -7.1pt; margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">• Ultrastructural characterization of diseases including the use of organoids, xenografts and animal models
</span></p>
<p style="text-indent: -7.1pt; margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">• Novel approaches and applications for correlative or hybrid microscopy
</span></p>
<p style="text-indent: -7.1pt; margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<b><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman""> </span></b></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<b style="mso-bidi-font-weight:normal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">B08 - Cryo-EM in Drug Discovery</span></b></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">Organizers: Leah Frye, Giovanna Scapin and Christel Verboven</span></p>
<p style="text-indent: -7.1pt; margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">• Cryo-EM in structure-based drug discovery
</span></p>
<p style="text-indent: -7.1pt; margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">• Cryo-EM in optimization of potency and selectivity
</span></p>
<p style="text-indent: -7.1pt; margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">• Use of cryo-EM to address classical ADMET issues such as hERG inhibition
</span></p>
<p style="text-indent: -7.1pt; margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">• Rapid and efficient determination of cryo- EM structures for drug discovery
</span></p>
<p style="text-indent: -7.1pt; margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<b><span style="font-family:"Times New Roman",serif;mso-fareast-font-family:"Times New Roman""> </span></b></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<b style="mso-bidi-font-weight:normal"><span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">B10 - Cryo-EM at local, regional, and national cryo-EM centers</span></b></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">Organizers: Claudia Lopez, Elizabeth Wright and Clint Potter</span></p>
<p style="text-indent: -7.1pt; margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman"">• Sample preparation: screening optimization
</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Hardware and software upgrades to optimize data collection<br>
• On the fly data processing. When to stop data collection? </span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">• Best practices in a cryoEM facility<br>
• How to best store, analyze, and share your data<br>
• Data processing: what are we missing? </span></p>
<p style="text-indent: -7.1pt; margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;mso-fareast-font-family:
"Times New Roman""> </span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">There are also interesting short courses Sunday before the meeting and tutorials during the meeting, check it out.</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman""><a href="https://urldefense.com/v3/__https://www.microscopy.org/MandM/2021/meetings/MM2021_CallforPapers.pdf__;!!Mih3wA!V8F7GNtV38kEVihVTUq1jKqs0CEe7ijZge6qPXgdQi1JNYwOjqKiS5C88XchunLnnQ$">https://www.microscopy.org/MandM/2021/meetings/MM2021_CallforPapers.pdf</a></span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman""> </span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">This is a great educational and networking meeting for the entire microscopy community. Students can benefit from a reduced registration fee ($50.00), as
well as Post-doctoral researchers ($195.00) and both will have ample opportunities to receive awards either before the meeting (make sure to check the corresponding box during submission) or during the poster session (for students). For more information go
to:</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman""><a href="https://urldefense.com/v3/__https://www.microscopy.org/MandM/2021/__;!!Mih3wA!V8F7GNtV38kEVihVTUq1jKqs0CEe7ijZge6qPXgdQi1JNYwOjqKiS5C88XeNvYAgyw$">https://www.microscopy.org/MandM/2021/</a></span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman""> </span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">We look forward to seeing many of you at the meeting.</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman""> </span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">Sincerely,</span></p>
<p style="margin: 0in 0in 0.0001pt; font-size: 12pt; font-family: "Calibri", sans-serif;">
<span style="font-size:10.5pt;font-family:"Arial",sans-serif;
mso-fareast-font-family:"Times New Roman"">Melanie, Teresa, Cheri and Bill</span></p>
</div>
<br>
<p></p>
<p><br>
</p>
<div id="Signature">
<div id="divtagdefaultwrapper" dir="ltr" style="font-size: 12pt; color: rgb(0, 0, 0); font-family: Calibri, Helvetica, sans-serif, "EmojiFont", "Apple Color Emoji", "Segoe UI Emoji", NotoColorEmoji, "Segoe UI Symbol", "Android Emoji", EmojiSymbols;">
<p>William J. Rice, PhD</p>
<p>Director, Cryo-Electron Microscopy Laboratory</p>
<p>NYU Langone Health</p>
<p>Smilow, SR C-10<br>
</p>
<p>522 First Ave., New York, NY 10016<br>
</p>
</div>
</div>
</div>
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