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<p class="MsoNormal"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;font-family:"Times New Roman",serif"><o:p> </o:p></span></font></p>
<p><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">Dear all,<o:p></o:p></span></font></p>
<p><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US"><o:p> </o:p></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">we have a post-doctoral researcher position to join the Klaholz group at the Centre for Integrative
Biology, IGBMC, Illkirch, France:<o:p></o:p></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US"><a href="https://urldefense.com/v3/__https://instruct-eric.eu/jobs/postdoctoral-researcher/__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFxb1yfGdg$">https://instruct-eric.eu/jobs/postdoctoral-researcher/</a><o:p></o:p></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US"><a href="https://urldefense.com/v3/__http://www.igbmc.fr/igbmc/recrutement/job_offer/524/__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFxFcmtvYA$">http://www.igbmc.fr/igbmc/recrutement/job_offer/524/</a><o:p></o:p></span></font></p>
<p style="text-align:justify"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;background:white"><a href="https://urldefense.com/v3/__https://www.linkedin.com/posts/bruno-klaholz-35893a125_we-have-an-open-position-for-a-post-doctoral-activity-6733065823482646528-tvhP__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFwNeUSj5Q$">https://www.linkedin.com/posts/bruno-klaholz-35893a125_we-have-an-open-position-for-a-post-doctoral-activity-6733065823482646528-tvhP</a><o:p></o:p></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US"><o:p> </o:p></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">We are studying the structure and function of
</span></font><font size="2"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US">large nucleo<font color="black"><span style="color:black">protein complexes</span></font> (ribosome complexes, chromatin complexes, viruses)<font color="black"><span style="color:black">
through integrated structural biology</span></font>, including biochemistry, crystallography,
<font color="black"><span style="color:black">high resolution cryo-EM</span></font>, tomography, super-resolution imaging & software developments<font color="black"><span style="color:black">.<o:p></o:p></span></font></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">We are looking for
</span></font><font size="2"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US">a<font color="black"><span style="color:black"> scientist with relevant expertise in structural biology, ideally with
</span></font>strong<font color="black"><span style="color:black"> exper</span></font>tis<font color="black"><span style="color:black">e in cryo electron microscopy or tomography. For further details please see below.<o:p></o:p></span></font></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US"><o:p> </o:p></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">Please contact me if you are interested.<o:p></o:p></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US"><o:p> </o:p></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">With best regards,<o:p></o:p></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US"><o:p> </o:p></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">Bruno Klaholz<o:p></o:p></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US"><o:p> </o:p></span></font></p>
<p><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US"><o:p> </o:p></span></font></p>
<p><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US"> <o:p></o:p></span></font></p>
<p><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">For ongoing projects and full publication list of the team see
</span></font><font size="2"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__http://igbmc.fr/Klaholz__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFwIQrsB4Q$"><span lang="EN-US" style="mso-ansi-language:EN-US">http://igbmc.fr/Klaholz</span></a></span></font><font size="2" color="black"><span style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">
<span lang="EN-US"><o:p></o:p></span></span></font></p>
<p><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US"> <o:p></o:p></span></font></p>
<p><u><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">Our group is located at the Centre for Integrative Biology (CBI) at IGBMC, Illkirch/Strasbourg, France, which comprises
cutting-edge cryo-EM facilities:</span></font></u><font size="2" color="black"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">
<o:p></o:p></span></font></p>
<p><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">The CBI provides a
</span></font><font size="2"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US">state-of-the-art<font color="black"><span style="color:black"> scientific and technological environment in integrated structural biology to address the structure
and function of biological systems, notably on gene expression, from the atomic, molecular to the tissue scales. The CBI
</span></font></span></font><font size="2"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__http://www.igbmc.fr/grandesstructures/cbi/__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFxvtkfvzA$"><span lang="EN-US" style="mso-ansi-language:EN-US">http://www.igbmc.fr/grandesstructures/cbi/</span></a></span></font><font size="2" color="black"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">
hosts the French and European Infrastructures for Integrated Structural Biology, FRISBI
</span></font><font size="2"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__http://frisbi.eu/__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFyvPslXkg$"><span lang="EN-US" style="mso-ansi-language:EN-US">http://frisbi.eu/</span></a></span></font><font size="2"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US">,
<font color="black"><span style="color:black">Instruct</span></font>-ERIC </span>
</font><font size="2"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__https://www.structuralbiology.eu/__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFz0AtdC4Q$"><span lang="EN-US" style="mso-ansi-language:EN-US">https://www.structuralbiology.eu/</span></a></span></font><font size="2" color="black"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US"> </span></font><font size="2"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US">and
iNext-Discovery </span></font><font size="2"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__https://inext-discovery.eu/network/inext-d/home__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFyR-Dx5hQ$"><span lang="EN-US" style="mso-ansi-language:EN-US">https://inext-discovery.eu/network/inext-d/home</span></a></span></font><font size="2"><span style="font-size:11.0pt;mso-ansi-language:EN-US">
<font color="black"><span lang="EN-US" style="color:black">which comprises advanced electron microscopy facilities equipped with cutting-edge instrumentation such as cryo electron microscopes including
</span></font><span lang="EN-US">a <font color="black"><span style="color:black">Titan Krios</span></font>, a Glacios (under installation), a Polara,<font color="black"><span style="color:black"> cryo Focused Ion Beam Scanning Electron Microscope (cryo-FIB/SEM)
and super-resolution fluorescence microscopy</span></font>, see </span></span></font><font size="2"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__http://frisbi.eu/centers/instruct-center-france-1-igbmc/cryo-electron-microscopy/__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFy2OirPrQ$">http://frisbi.eu/centers/instruct-center-france-1-igbmc/cryo-electron-microscopy/</a></span></font><font size="2" color="black"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">.
The Titan Krios microscope is equipped with K3 camera, Falcon 3 camera, GIF energy filter and phase plate. In addition, the EM facility has a suite of associated equipments for sample preparation and dedicated computing resources for image processing and 3D
reconstruction by single particle cryo-EM and cryo electron tomography.<o:p></o:p></span></font></p>
<p><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US"> </span></font><font size="2"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US"><o:p></o:p></span></font></p>
<p><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">Highly-motivated candidates with a recent PhD or MD/PhD in structural biology and specifically in cryo-EM or cryo-ET are encouraged
to apply. <o:p></o:p></span></font></p>
<p><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">Candidates should have strong expertise in protein biochemistry, in cryo-ET and/or in cryo-EM, image processing & atomic model
refinement with various programs; computational skills are a strong plus. The candidate should have excellent writing and communication skills in English, be able to work independently and have a strong team spirit.<o:p></o:p></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">We are studying the structure and function of protein complexes</span></font><font size="2"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US">
(ribosome complexes, chromatin complexes, viruses)<font color="black"><span style="color:black"> through integrated structural biology</span></font>, including biochemical and biophysical methods, crystallography,
<font color="black"><span style="color:black">high resolution cryo-EM</span></font>, tomography, super-resolution imaging & software developments<font color="black"><span style="color:black">. Several projects are available for outstanding young scientists
who would like to combine these approaches.<o:p></o:p></span></font></span></font></p>
<p style="text-align:justify"><font size="2" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">Applications should be sent via email to
</span></font><font size="2"><span style="font-size:11.0pt"><a href="mailto:klaholz@igbmc.fr"><span lang="EN-US" style="mso-ansi-language:EN-US">klaholz@igbmc.fr</span></a></span></font><font size="2" color="black"><span lang="EN-US" style="font-size:11.0pt;color:black;mso-ansi-language:EN-US">
including CV, list of publications, names of 3 referees and motivation letter. Deadline for application: Jan 8<sup>th</sup> 2021.</span></font><font size="2"><span lang="EN-US" style="font-size:11.0pt;mso-ansi-language:EN-US"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-ansi-language:EN-US"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-fareast-language:EN-GB">###########################################################################<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-fareast-language:EN-GB">Bruno P. Klaholz<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-fareast-language:EN-GB">Centre for Integrative Biology<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-fareast-language:EN-GB">Department of Integrated Structural Biology<br>
Institute of Genetics and of Molecular and Cellular Biology<br>
IGBMC - UMR 7104 - U 1258<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-fareast-language:EN-GB">1, rue Laurent Fries<br>
BP 10142 <br>
67404 ILLKIRCH CEDEX<br>
FRANCE<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-fareast-language:EN-GB">Tel. from abroad:<b><font color="red"><span style="color:red;font-weight:bold">
</span></font></b>0033.369.48.52.78<br>
Tel. inside France: 03.69.48.52.78<br>
websites:<br>
</span></font><a href="https://urldefense.com/v3/__http://www.igbmc.fr/research/department/3/team/36/__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFxbRJZKBg$"><font color="blue" face="Times New Roman"><span style="font-family:"Times New Roman",serif;color:blue">http://www.igbmc.fr/research/department/3/team/36/</span></font></a><font face="Times New Roman"><span style="font-family:"Times New Roman",serif;mso-fareast-language:EN-GB"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__http://www.igbmc.fr/grandesstructures/cbi/__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFxvtkfvzA$" target="_blank"><font color="blue" face="Times New Roman"><span style="font-family:"Times New Roman",serif;color:blue;mso-fareast-language:EN-GB">http://www.igbmc.fr/grandesstructures/cbi</span></font></a></span></font><font face="Times New Roman"><span style="font-family:"Times New Roman",serif;mso-fareast-language:EN-GB"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__http://frisbi.eu/__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFyvPslXkg$" target="_blank"><font color="blue" face="Times New Roman"><span style="font-family:"Times New Roman",serif;color:blue;mso-fareast-language:EN-GB">http://frisbi.eu</span></font></a></span></font><font face="Times New Roman"><span style="font-family:"Times New Roman",serif"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__http://instruct-eric.eu/__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFwCJiXWUQ$"><font color="blue" face="Times New Roman"><span style="font-family:"Times New Roman",serif;color:blue;mso-fareast-language:EN-GB">http://instruct-eric.eu</span></font></a></span></font><font face="Times New Roman"><span style="font-family:"Times New Roman",serif"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__https://inext-discovery.eu/__;!!Mih3wA!WX5Q_0N8HFMLvpyVVtz0H3kR5XnHCkldvwZQcEtfeN5vTitZwSSNsQtOUFzIHobe5g$"><font color="blue" face="Times New Roman"><span style="font-family:"Times New Roman",serif;color:blue">https://inext-discovery.eu</span></font></a></span></font><font face="Times New Roman"><span style="font-family:"Times New Roman",serif"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt"><o:p> </o:p></span></font></p>
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