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<a></a><b><span style="font-size:14.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Postdoctoral position in cryo-EM and translation regulation ‒ from bacteria to neurons<o:p> </o:p></span></b></p>
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<b><span style="font-size:14.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial"><o:p> </o:p></span></b></p>
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<b><span style="font-size:14.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Korostelev Lab, University of Massachusetts Medical School</span></b><span style="font-size:12.0pt;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:"Times New Roman""><o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial"><o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">We study how the ribosome interacts with numerous cellular components to achieve high accuracy and efficiency of gene expression. We’d like
to understand the key roles of translation and ribosomes in: (1) Neurodevelopment and neurodegenerative diseases; (2) Bacterial stress signaling and gene regulation (<i>e.g.</i> coupling with transcription); and other aspects of gene expression (</span><span style="mso-field-code:"HYPERLINK \0022https\"><span class="MsoHyperlink" style="color:blue;text-decoration:underline"><span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial"><a href="https://urldefense.com/v3/__https://www.umassmed.edu/korostelev-lab/__;!!Mih3wA!RnZXPqYaCU7xD93tk1A43hl3q5mojHSDfKvYzoLvsOzRhwZ7TpaR5IhGl3w6mp1kdA$">https://www.umassmed.edu/korostelev-lab/</a></span></span></span>)<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">.
We use a range of approaches, including cryo-EM and biochemistry (see selected references below).</span><span style="font-size:12.0pt;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:"Times New Roman""><o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Our laboratory is housed at the RNA Therapeutics Institute, a vibrant and highly interactive research community:
</span><span style="mso-field-code:"HYPERLINK \0022https\"><span class="MsoHyperlink" style="color:blue;text-decoration:underline"><span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial"><a href="https://urldefense.com/v3/__https://www.umassmed.edu/rti/about-the-rti/faculty-members/__;!!Mih3wA!RnZXPqYaCU7xD93tk1A43hl3q5mojHSDfKvYzoLvsOzRhwZ7TpaR5IhGl3wXJ3Pl3Q$">https://www.umassmed.edu/rti/about-the-rti/faculty-members/</a></span></span></span><span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">.<span style="mso-spacerun:yes">
</span>Our colleagues are interested in nearly all aspects of RNA biology, from small to large RNAs to RNA chemistry and therapeutics development.<o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial"><o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">We seek a highly motivated person who very recently received a PhD, or will soon receive a PhD.<span style="mso-spacerun:yes">
</span>Applications sent prior to the dissertation defense date are welcome.<o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">If you are interested in using single-particle cryo-EM and in
<i>situ </i>(cellular) EM to elucidate cellular mechanisms, <b>submit the following information to
</b></span><a href="mailto:ann.powers@umassmed.edu"><b><i><span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">ann.powers@umassmed.edu</span></i></b></a><span class="MsoHyperlink" style="color:blue;text-decoration:underline"><i><span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">:</span></i></span><i><span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial"><o:p> </o:p></span></i></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">1)<span style="mso-tab-count:1">
</span><i>Your CV </i>(including your publication list);<br>
2)<span style="mso-tab-count:1"> </span><i>Cover letter</i> (less than 2 pages) describing:
</span><span style="font-size:12.0pt;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:"Times New Roman""><o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial"> (i) your previous work - focusing on your most interesting finding(s),</span><span style="font-size:12.0pt;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:"Times New Roman""><o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial"> (ii) your scientific interests,
<o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial"><span style="mso-spacerun:yes">
</span>(iii) which aspects of translation regulation are of interest to you.</span><span style="font-size:12.0pt;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:"Times New Roman""><o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">3)
<span style="mso-tab-count:1"> </span><i>Email addresses of</i> <i>three references</i>.</span><span style="font-size:12.0pt;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:"Times New Roman""><o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial"><o:p> </o:p></span></p>
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<b><span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Selected publications (accessible via the provided links):</span></b><b><span style="font-size:12.0pt;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:"Times New Roman""><o:p> </o:p></span></b></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">•<span style="mso-tab-count:1">
</span></span><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Carbone CE, Demo G, Madireddy R, Svidritskiy E, Korostelev AA. “</span><a href="https://urldefense.com/v3/__https://www.nature.com/articles/s41467-020-19370-z__;!!Mih3wA!RnZXPqYaCU7xD93tk1A43hl3q5mojHSDfKvYzoLvsOzRhwZ7TpaR5IhGl3y7CiTskA$"><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">ArfB
can displace mRNA to rescue stalled ribosomes</span></a><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">”.
<i>Nature Commun</i>. 2020.<o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">•<span style="mso-tab-count:1">
</span></span><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Loveland AB, Demo G, Korostelev AA. “</span><a href="https://urldefense.com/v3/__https://www.nature.com/articles/s41586-020-2447-x__;!!Mih3wA!RnZXPqYaCU7xD93tk1A43hl3q5mojHSDfKvYzoLvsOzRhwZ7TpaR5IhGl3xT7ayEfg$"><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Cryo-EM
of elongating ribosome with EF-Tu GTP elucidates tRNA proofreading</span></a><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">”.
<i>Nature</i>. 2020.<o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">•<span style="mso-tab-count:1">
</span></span><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Loveland AB, Svidritskiy E, Susorov D, Lee S, Park A, Demo G, Gao FB, Korostelev AA. “</span><a href="file:///C:\Users\PowersA\Dropbox%20(UMass%20Medical%20School)\Korostelev\Job%20Postings\Susorov%20D%20et%20al.%20%22Termi-Luc:%20a%20versatile%20assay%20to%20monitor%20full-protein%20release%20from%20ribosomes"><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Ribosome
inhibition by C9ORF72-ALS/FTD-associated poly-PR and poly-GR proteins revealed by cryo-EM</span></a><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">”.
<i>bioRxiv.</i> 2020.<o:p> </o:p></span></p>
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<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">•<span style="mso-tab-count:1">
</span></span><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Susorov D, Egri S, Korostelev AA. "</span><a href="https://urldefense.com/v3/__https://rnajournal.cshlp.org/content/early/2020/08/14/rna.076588.120.abstract__;!!Mih3wA!RnZXPqYaCU7xD93tk1A43hl3q5mojHSDfKvYzoLvsOzRhwZ7TpaR5IhGl3yGrWY9hw$"><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Termi-Luc:
a versatile assay to monitor full-protein release from ribosomes</span></a><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">”.
<i>RNA</i>. 2020.<o:p> </o:p></span></p>
<p class="MsoNormal" style="margin:0in 0in 10pt;line-height:120%;font-size:11pt;font-family:"Times New Roman";margin-top:6.0pt;margin-right:40.5pt;margin-bottom:6.0pt;margin-left:40.5pt">
<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">•<span style="mso-tab-count:1">
</span></span><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Svidritskiy E, Demo G, Loveland AB, Xu C, Korostelev AA. “</span><a href="https://urldefense.com/v3/__https://elifesciences.org/articles/46850__;!!Mih3wA!RnZXPqYaCU7xD93tk1A43hl3q5mojHSDfKvYzoLvsOzRhwZ7TpaR5IhGl3xTIMiWwA$"><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Extensive
ribosome and RF2 rearrangements during translation termination</span></a><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">”.
<i>eLife.</i> 2019.<o:p> </o:p></span></p>
<p class="MsoNormal" style="margin:0in 0in 10pt;line-height:120%;font-size:11pt;font-family:"Times New Roman";margin-top:6.0pt;margin-right:40.5pt;margin-bottom:6.0pt;margin-left:40.5pt">
<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">•<span style="mso-tab-count:1">
</span></span><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Loveland AB, Demo G, Grigorieff N, Korostelev AA. “</span><a href="https://urldefense.com/v3/__http://em.rdcu.be/wf/click?upn=KP7O1RED-2BlD0F9LDqGVeSIKXTPnBku1A9OWTgBG4xjQ-3D_rJ0Q-2F8zH14bc-2FDhyIYgAaaIoDtN-2BMVA8uQ8ik0weaaWU8PS-2BLdbyuwTFcQze4H7H3NsgdQgtZP22s4d-2F7Ah5F9SEpNUyeYFo-2BwrMeGTv8bX708iwdYFE7myt3Zo8qQ0eqg1fJusX-2BXV1bNBbSZvYswm3izFmUn2nS__;!!Mih3wA!RnZXPqYaCU7xD93tk1A43hl3q5mojHSDfKvYzoLvsOzRhwZ7TpaR5IhGl3yO9gxqeA$"><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Ensemble
cryo-EM elucidates the mechanism of translation fidelity</span></a><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">”.
<i>Nature</i>. 2017.<o:p> </o:p></span></p>
<p class="MsoNormal" style="margin:0in 0in 10pt;line-height:120%;font-size:11pt;font-family:"Times New Roman";margin-top:6.0pt;margin-right:40.5pt;margin-bottom:6.0pt;margin-left:40.5pt">
<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">•<span style="mso-tab-count:1">
</span></span><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Demo G, Rasouly A, Vasilyev N, Svetlov V, Loveland AB, Diaz-Avalos R, Grigorieff N, Nudler E, Korostelev AA. “</span><a href="https://urldefense.com/v3/__https://elifesciences.org/articles/28560__;!!Mih3wA!RnZXPqYaCU7xD93tk1A43hl3q5mojHSDfKvYzoLvsOzRhwZ7TpaR5IhGl3yjVBYD1g$"><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Structure
of RNA polymerase bound to ribosomal 30S subunit</span></a><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">”.
<i>eLife</i>. 2017.<o:p> </o:p></span></p>
<p class="MsoNormal" style="margin:0in 0in 10pt;line-height:120%;font-size:11pt;font-family:"Times New Roman";margin-top:6.0pt;margin-right:40.5pt;margin-bottom:6.0pt;margin-left:40.5pt">
<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">•<span style="mso-tab-count:1">
</span></span><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Abeyrathne PD, Koh CS, Grant T, Grigorieff N, Korostelev AA. “</span><a href="https://urldefense.com/v3/__https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4896748/__;!!Mih3wA!RnZXPqYaCU7xD93tk1A43hl3q5mojHSDfKvYzoLvsOzRhwZ7TpaR5IhGl3wTkFQLUA$"><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Ensemble
cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome</span></a><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">”.
<i>eLife</i>. 2016.<o:p> </o:p></span></p>
<p class="MsoNormal" style="margin:0in 0in 10pt;line-height:120%;font-size:11pt;font-family:"Times New Roman";margin-top:6.0pt;margin-right:40.5pt;margin-bottom:6.0pt;margin-left:40.5pt">
<span style="font-size:12.0pt;font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">•<span style="mso-tab-count:1">
</span></span><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Loveland AB, Bah E, Madireddy R, Zhang Y, Brilot AF, Grigorieff N, Korostelev AA. “</span><a href="https://urldefense.com/v3/__https://elifesciences.org/articles/17029__;!!Mih3wA!RnZXPqYaCU7xD93tk1A43hl3q5mojHSDfKvYzoLvsOzRhwZ7TpaR5IhGl3zqW-TAiA$"><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">Ribosome•RelA
structures reveal the mechanism of stringent response activation</span></a><span style="font-family:Arial;mso-fareast-font-family:"Times New Roman";mso-bidi-font-family:Arial">”.
<i>eLife</i>. 2016.<o:p> </o:p></span></p>
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