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<!--StartFragment--><p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif;color:#333333" class="">Rectify
Pharmaceuticals seeks a highly motivated candidate with state-of-the-art
expertise in integral membrane protein biochemistry. The successful
candidate will express, purify and reconstitute transporters into liposomes and
nanodiscs, develop functional assays and carry out cryo-EM structural studies
with transporters implicated in rare disease. </span><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-bottom:6.0pt"><u class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class="">Key responsibilities:</span></u><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-left:9.0pt;text-indent:-9.0pt"><span style="font-size: 12pt; font-family: Georgia, serif;" class="">- Design
protein expression constructs and optimize yield and protein quality from insect
and mammalian expression hosts<o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-left:9.0pt;text-indent:-9.0pt"><span style="font-size: 12pt; font-family: Georgia, serif;" class="">- Purify and
reconstitute membrane proteins into lipid environments such as liposomes
and nanodiscs for functional assay development and structural studies<o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-left:9.0pt;text-indent:-9.0pt"><span style="font-size: 12pt; font-family: Georgia, serif;" class="">- Design
small-scale activity assays for key disease mutants<o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-left:9.0pt;text-indent:-9.0pt"><span style="font-size: 12pt; font-family: Georgia, serif;" class="">- Characterize
transporter structure and folding state using cryo-EM or other biophysical
methods<o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-left:9.0pt;text-indent:-9.0pt"><br class=""></p><p class="MsoNormal" style="margin-top:0in;margin-right:0in;margin-bottom:6.0pt;
margin-left:9.35pt;text-indent:-9.35pt"><u class=""><span style="font-size: 12pt; font-family: Georgia, serif;" class="">Qualifications:</span></u><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-left:9.0pt;text-indent:-9.0pt"><span style="font-size: 12pt; font-family: Georgia, serif;" class="">- </span><span style="font-size:12.0pt;font-family:"Georgia",serif;color:#333333" class="">Must have
Ph.D. (or equivalent degree) in Protein Biochemistry, Structural Biology or a
related field</span><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-left:9.0pt;text-indent:-9.0pt"><span style="font-size:12.0pt;font-family:"Georgia",serif;color:#333333" class="">-
Proven expertise in membrane protein biochemistry as evidenced by a strong
publication record and references</span><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-left:9.0pt;text-indent:-9.0pt"><span style="font-size:12.0pt;font-family:"Georgia",serif;color:#333333" class="">-
Experience in mammalian protein expression, functional assay development
or cryo-EM a plus</span><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""></o:p></span></p><p class="MsoNormal" style="margin-left:9.0pt;text-indent:-9.0pt"><span style="font-size:12.0pt;font-family:"Georgia",serif;color:#333333" class="">- Excellent
communication skills (written and oral) and the ability to work in a
close-knit, team environment is required</span></p><div class=""><br class=""></div><p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif;
color:#333333" class="">Interested candidates should send a cv with cover letter to
the email address below:</span><span style="font-size: 12pt; font-family: Georgia, serif;" class=""><o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif" class=""><a href="mailto:careers@rectifypharma.com" class="">careers@rectifypharma.com</a><o:p class=""></o:p></span></p><p class="MsoNormal"><span style="font-size:12.0pt;font-family:"Georgia",serif;
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