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<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><span style="font-size:11.0pt;color:black">S<sup><span style="border:none windowtext 1.0pt;padding:0in">2</span></sup>C<sup><span style="border:none windowtext 1.0pt;padding:0in">2</span></sup> Workshop
</span></b><span style="font-size:11.0pt;color:black">–<b> </b>CryoEM of COVID-related Macromolecules, </span><b><span style="font-size:11.0pt">September
<span style="color:black">28, 2020</span></span></b><span style="font-size:11.0pt;color:black"> 8:00 AM–<b>
</b>1:00 PM (PDT)</span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><span style="font-size:11.0pt;color:black"> </span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Held as part of a suite of workshops during the SSRL/LCLS Annual Users’ Meeting, this session highlights the recent use of cryoEM structure determination of SARS-COVID-2 related macromolecules. Speakers will
cover structures of different molecular components of the virus and the cellular interacting partners. Some of talks will describe the impact of the structural results on vaccine and drug developments.<span style="border:none windowtext 1.0pt;padding:0in">
There is no cost for this workshop but you must register by 5 PM Pacific, September 25. Register: </span><span style="color:#002060"><a href="https://urldefense.com/v3/__https://events.bizzabo.com/SLAC-UsersMeeting-2020__;!!Mih3wA!Qu7htdQglOeZnGCO2caXpg-b8s171BlEA4AqMaRI5vcEA6j5MJ4JbEjlb2FrHz6vUg$">https://events.bizzabo.com/SLAC-UsersMeeting-2020</a><o:p></o:p></span></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#002060"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Agenda:<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:23.25pt;text-indent:-.25in;mso-list:l0 level1 lfo2">
<![if !supportLists]><span style="font-size:11.0pt"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><b><span style="font-size:11.0pt">David Veesler</span></b><span style="font-size:11.0pt">, University of Washington, Seattle: <em><span style="font-family:"Calibri",sans-serif;font-style:normal">Structural studies of the SARS-CoV
Spike Glycoprotein</span></em><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:23.25pt;text-indent:-.25in;mso-list:l0 level1 lfo2">
<![if !supportLists]><span style="font-size:11.0pt"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><em><b><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;font-style:normal">David Stuart</span></b></em><em><span style="font-size:11.0pt;font-family:"Calibri",sans-serif;font-style:normal">,
</span></em><span style="font-size:11.0pt">Oxford University and Diamond Light Source: <em><span style="font-family:"Calibri",sans-serif;font-style:normal">The use of cryoEM structural information to advance SARS2-CoV-2 biology and therapy</span></em><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:23.25pt;text-indent:-.25in;mso-list:l0 level1 lfo2">
<![if !supportLists]><span style="font-size:11.0pt"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><strong><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Goran Kokic</span></strong><span style="font-size:11.0pt">, Max Planck Institute for Biophysical Chemistry, Göttingen:
<em><span style="font-family:"Calibri",sans-serif;font-style:normal">Structure of replicating SARS-COV-2 polymerase</span></em><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:23.25pt;text-indent:-.25in;mso-list:l0 level1 lfo2">
<![if !supportLists]><span style="font-size:11.0pt"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><strong><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Erica Ollmann Saphire,</span></strong><span style="font-size:11.0pt"> La Jolla Institute for Immunology: <em><span style="font-family:"Calibri",sans-serif;font-style:normal">Antibodies
against Emerging Viral Disease</span></em><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:23.25pt;text-indent:-.25in;mso-list:l0 level1 lfo2">
<![if !supportLists]><span style="font-size:11.0pt"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><strong><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Rhiju Das</span></strong><span style="font-size:11.0pt">, Stanford University: <em><span style="font-family:"Calibri",sans-serif;font-style:normal">CryoEM
of previously unsolvable RNA structures including coronavirus genome element</span></em><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-left:23.25pt;text-indent:-.25in;mso-list:l0 level1 lfo2">
<![if !supportLists]><span style="font-size:11.0pt"><span style="mso-list:Ignore">-<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><strong><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Stephan Wilkens</span></strong><span style="font-size:11.0pt">, SUNY Upstate Medical University, Syracuse:
<i> </i><em><span style="font-family:"Calibri",sans-serif;font-style:normal">Targeting Vacuolar H+-ATPase for Antiviral Therapy</span></em><i> </i><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Organizer: Wah Chiu, Stanford University<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#002060"> </span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-size:11.0pt">The S<sup>2</sup>C<sup>2</sup> is supported by the National Institutes of Health Common Fund <span style="color:#002060"><a href="https://urldefense.com/v3/__https://commonfund.nih.gov/cryoem__;!!Mih3wA!Qu7htdQglOeZnGCO2caXpg-b8s171BlEA4AqMaRI5vcEA6j5MJ4JbEjlb2GXO_hgwQ$" target="_blank" title="https://commonfund.nih.gov/cryoem"><span style="color:#002060">Transformative
High Resolution Cryo-Electron Microscopy</span></a> </span>program.</span></i><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:#1F497D"> </span><span style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
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