<html xmlns:v="urn:schemas-microsoft-com:vml" xmlns:o="urn:schemas-microsoft-com:office:office" xmlns:w="urn:schemas-microsoft-com:office:word" xmlns:m="http://schemas.microsoft.com/office/2004/12/omml" xmlns="http://www.w3.org/TR/REC-html40">
<head>
<meta http-equiv="Content-Type" content="text/html; charset=us-ascii">
<meta name="Generator" content="Microsoft Word 15 (filtered medium)">
<style><!--
/* Font Definitions */
@font-face
{font-family:Wingdings;
panose-1:5 0 0 0 0 0 0 0 0 0;}
@font-face
{font-family:"Cambria Math";
panose-1:2 4 5 3 5 4 6 3 2 4;}
@font-face
{font-family:Calibri;
panose-1:2 15 5 2 2 2 4 3 2 4;}
/* Style Definitions */
p.MsoNormal, li.MsoNormal, div.MsoNormal
{margin:0cm;
margin-bottom:.0001pt;
font-size:11.0pt;
font-family:"Calibri",sans-serif;
mso-fareast-language:EN-US;}
h1
{mso-style-priority:9;
mso-style-link:"Heading 1 Char";
mso-margin-top-alt:auto;
margin-right:0cm;
mso-margin-bottom-alt:auto;
margin-left:0cm;
font-size:24.0pt;
font-family:"Times New Roman",serif;
font-weight:bold;}
a:link, span.MsoHyperlink
{mso-style-priority:99;
color:#0563C1;
text-decoration:underline;}
a:visited, span.MsoHyperlinkFollowed
{mso-style-priority:99;
color:#954F72;
text-decoration:underline;}
p.MsoPlainText, li.MsoPlainText, div.MsoPlainText
{mso-style-priority:99;
mso-style-link:"Plain Text Char";
margin:0cm;
margin-bottom:.0001pt;
font-size:11.0pt;
font-family:"Calibri",sans-serif;}
p
{mso-style-priority:99;
margin:0cm;
margin-bottom:.0001pt;
font-size:12.0pt;
font-family:"Times New Roman",serif;}
p.MsoNoSpacing, li.MsoNoSpacing, div.MsoNoSpacing
{mso-style-priority:1;
margin:0cm;
margin-bottom:.0001pt;
font-size:11.0pt;
font-family:"Calibri",sans-serif;
mso-fareast-language:EN-US;}
span.PlainTextChar
{mso-style-name:"Plain Text Char";
mso-style-priority:99;
mso-style-link:"Plain Text";
font-family:"Calibri",sans-serif;
mso-fareast-language:EN-GB;}
span.EmailStyle21
{mso-style-type:personal;
font-family:"Calibri",sans-serif;
color:windowtext;}
span.jrnl
{mso-style-name:jrnl;}
span.EmailStyle25
{mso-style-type:personal-reply;
font-family:"Calibri",sans-serif;
color:windowtext;
font-weight:normal;
font-style:normal;}
span.Heading1Char
{mso-style-name:"Heading 1 Char";
mso-style-priority:9;
mso-style-link:"Heading 1";
font-weight:bold;}
.MsoChpDefault
{mso-style-type:export-only;
font-size:10.0pt;}
@page WordSection1
{size:612.0pt 792.0pt;
margin:72.0pt 72.0pt 72.0pt 72.0pt;}
div.WordSection1
{page:WordSection1;}
/* List Definitions */
@list l0
{mso-list-id:62602546;
mso-list-template-ids:-1170306690;}
@list l0:level1
{mso-level-number-format:bullet;
mso-level-text:\F0B7;
mso-level-tab-stop:36.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Symbol;}
@list l0:level2
{mso-level-number-format:bullet;
mso-level-text:o;
mso-level-tab-stop:72.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:"Courier New";
mso-bidi-font-family:"Times New Roman";}
@list l0:level3
{mso-level-number-format:bullet;
mso-level-text:\F0A7;
mso-level-tab-stop:108.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
@list l0:level4
{mso-level-number-format:bullet;
mso-level-text:\F0A7;
mso-level-tab-stop:144.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
@list l0:level5
{mso-level-number-format:bullet;
mso-level-text:\F0A7;
mso-level-tab-stop:180.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
@list l0:level6
{mso-level-number-format:bullet;
mso-level-text:\F0A7;
mso-level-tab-stop:216.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
@list l0:level7
{mso-level-number-format:bullet;
mso-level-text:\F0A7;
mso-level-tab-stop:252.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
@list l0:level8
{mso-level-number-format:bullet;
mso-level-text:\F0A7;
mso-level-tab-stop:288.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
@list l0:level9
{mso-level-number-format:bullet;
mso-level-text:\F0A7;
mso-level-tab-stop:324.0pt;
mso-level-number-position:left;
text-indent:-18.0pt;
mso-ansi-font-size:10.0pt;
font-family:Wingdings;}
ol
{margin-bottom:0cm;}
ul
{margin-bottom:0cm;}
--></style><!--[if gte mso 9]><xml>
<o:shapedefaults v:ext="edit" spidmax="1026" />
</xml><![endif]--><!--[if gte mso 9]><xml>
<o:shapelayout v:ext="edit">
<o:idmap v:ext="edit" data="1" />
</o:shapelayout></xml><![endif]-->
</head>
<body lang="EN-GB" link="#0563C1" vlink="#954F72">
<div class="WordSection1">
<p class="MsoNormal"><font size="3" face="Times New Roman"><span style="font-size:12.0pt;font-family:"Times New Roman",serif"><o:p> </o:p></span></font></p>
<p><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">Dear all,<o:p></o:p></span></font></p>
<p><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black"><o:p> </o:p></span></font></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">we have
</span></font><span lang="EN-US">an<font color="black"><span style="color:black"> open positio</span></font>n<font color="black"><span style="color:black"> for a
<u>post-doctoral researcher</u> to join the Klaholz group at the Centre for Integrative Biology, IGBMC, Illkirch, France
<a href="https://urldefense.com/v3/__http://igbmc.fr/Klaholz__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XQ_Lv5-3g$">http://igbmc.fr/Klaholz</a></span></font> <font color="black">
<span style="color:black"><o:p></o:p></span></font></span></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black"><o:p> </o:p></span></font></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">We are studying the structure and function of
</span></font><span lang="EN-US">large nucleo<font color="black"><span style="color:black">protein complexes</span></font> (ribosome complexes, chromatin complexes, viruses)<font color="black"><span style="color:black"> through integrated structural biology</span></font>,
including biochemistry, crystallography, <font color="black"><span style="color:black">high resolution cryo-EM</span></font>, tomography, super-resolution imaging & software developments<font color="black"><span style="color:black">.<o:p></o:p></span></font></span></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">We are looking for
</span></font><span lang="EN-US">a<font color="black"><span style="color:black"> highly motivated scientist with relevant expertise in structural biology, ideally with
</span></font>strong<font color="black"><span style="color:black"> exper</span></font>tis<font color="black"><span style="color:black">e in cryo electron microscopy. For further details please see below.<o:p></o:p></span></font></span></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black"><o:p> </o:p></span></font></p>
<p style="text-align:justify"><u><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">2 further positions</span></font></u><font color="black"><span lang="EN-US" style="color:black"> are available on our
structural biology platform <a href="https://urldefense.com/v3/__http://frisbi.eu/centers/instruct-center-france-1-igbmc/__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XTxNYnzsg$">
http://frisbi.eu/centers/instruct-center-france-1-igbmc/</a>: <o:p></o:p></span></font></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">- IT position in cryo-EM: systems and network engineer for cryo electron microscopy
<b><span style="font-weight:bold"> </span></b></span></font><span lang="EN-US"> <a href="https://urldefense.com/v3/__https://emploi.cnrs.fr/Offres/CDD/UMR7104-GUEBUR-009/Default.aspx?lang=EN__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XSSjurZ_Q$">https://emploi.cnrs.fr/Offres/CDD/UMR7104-GUEBUR-009/Default.aspx?lang=EN</a>
<b><font color="black"><span style="color:black;font-weight:bold"><o:p></o:p></span></font></b></span></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">- engineer or postdoc position for developments in super-resolution microscopy (please contact me if interested)<o:p></o:p></span></font></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black"><o:p> </o:p></span></font></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">With best regards,<o:p></o:p></span></font></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black"><o:p> </o:p></span></font></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">Bruno Klaholz<o:p></o:p></span></font></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black"><o:p> </o:p></span></font></p>
<p><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black"><o:p> </o:p></span></font></p>
<p><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black"> <o:p></o:p></span></font></p>
<p><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">For ongoing projects and full publication list of the team see
<a href="https://urldefense.com/v3/__http://igbmc.fr/Klaholz__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XQ_Lv5-3g$">http://igbmc.fr/Klaholz</a> <o:p></o:p></span></font></p>
<p><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black"> <o:p></o:p></span></font></p>
<p><u><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">Our group is located at the Centre for Integrative Biology (CBI) at IGBMC, Illkirch/Strasbourg, France, which comprises cutting-edge cryo-EM facilities:</span></font></u><font color="black"><span lang="EN-US" style="color:black">
<o:p></o:p></span></font></p>
<p><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">The CBI provides a
</span></font><span lang="EN-US">state-of-the-art<font color="black"><span style="color:black"> scientific and technological environment in integrated structural biology to address the structure and function of biological systems, notably on gene expression,
from the atomic, molecular to the tissue scales. The CBI <a href="https://urldefense.com/v3/__http://www.igbmc.fr/grandesstructures/cbi/__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XTaEEL8TA$">
http://www.igbmc.fr/grandesstructures/cbi/</a> hosts the French and European Infrastructures for Integrated Structural Biology, FRISBI
<a href="https://urldefense.com/v3/__http://frisbi.eu/__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XRYJ30Z6A$">http://frisbi.eu/</a></span></font>, <font color="black">
<span style="color:black">Instruct</span></font>-ERIC <font color="black"><span style="color:black"><a href="https://urldefense.com/v3/__https://www.structuralbiology.eu/__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XRgX7HXgQ$">https://www.structuralbiology.eu/</a>
</span></font>and iNext-Discovery <a href="https://urldefense.com/v3/__https://inext-discovery.eu/network/inext-d/home__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XQBYXP5Dg$">
https://inext-discovery.eu/network/inext-d/home</a> <font color="black"><span style="color:black">which comprises advanced electron microscopy facilities equipped with cutting-edge instrumentation such as cryo electron microscopes including
</span></font>a <font color="black"><span style="color:black">Titan Krios</span></font>, a Glacios (under installation), a Polara,<font color="black"><span style="color:black"> cryo Focused Ion Beam Scanning Electron Microscope (cryo-FIB/SEM) and super-resolution
fluorescence microscopy</span></font>, see </span><a href="https://urldefense.com/v3/__http://frisbi.eu/centers/instruct-center-france-1-igbmc/cryo-electron-microscopy/__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XRiQJ9Uew$">http://frisbi.eu/centers/instruct-center-france-1-igbmc/cryo-electron-microscopy/</a><font color="black"><span lang="EN-US" style="color:black">.
The Titan Krios microscope is equipped with K3 camera, Falcon 3 camera, GIF energy filter and phase plate. In addition, the EM facility has a suite of associated equipments for sample preparation and dedicated computing resources for image processing and 3D
reconstruction by single particle cryo-EM and cryo electron tomography.<o:p></o:p></span></font></p>
<p><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black"> </span></font><span lang="EN-US"><o:p></o:p></span></p>
<p><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">Highly-motivated candidates with a recent PhD or MD/PhD in structural biology and specifically in cryo-EM are encouraged to apply.
<o:p></o:p></span></font></p>
<p><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">Candidates should have strong expertise in protein biochemistry, in cryo-ET and/or in cryo-EM, image processing & atomic model refinement with various
programs; computational skills are a strong plus. The candidate should have excellent writing and communication skills in English, be able to work independently and have a strong team spirit.<o:p></o:p></span></font></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">We are studying the structure and function of protein complexes</span></font><span lang="EN-US"> (ribosome complexes, chromatin
complexes, viruses)<font color="black"><span style="color:black"> through integrated structural biology</span></font>, including biochemical and biophysical methods, crystallography,
<font color="black"><span style="color:black">high resolution cryo-EM</span></font>, tomography, super-resolution imaging & software developments<font color="black"><span style="color:black">. Several projects are available for outstanding young scientists
who would like to combine these approaches.<o:p></o:p></span></font></span></p>
<p style="text-align:justify"><font size="3" color="black" face="Times New Roman"><span lang="EN-US" style="font-size:12.0pt;color:black">Applications should be sent via email to
<a href="mailto:klaholz@igbmc.fr">klaholz@igbmc.fr</a> including CV, list of publications, names of 3 referees and motivation letter. The postdoctoral position remains open until filled.</span></font><span lang="EN-US"><o:p></o:p></span></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span lang="EN-US" style="font-size:11.0pt;font-family:"Times New Roman",serif"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt"><o:p> </o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-fareast-language:EN-GB">###########################################################################<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-fareast-language:EN-GB">Bruno P. Klaholz<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-fareast-language:EN-GB">Centre for Integrative Biology<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-fareast-language:EN-GB">Department of Integrated Structural Biology<br>
Institute of Genetics and of Molecular and Cellular Biology<br>
IGBMC - UMR 7104 - U 1258<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-fareast-language:EN-GB">1, rue Laurent Fries<br>
BP 10142 <br>
67404 ILLKIRCH CEDEX<br>
FRANCE<o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Times New Roman"><span style="font-size:11.0pt;font-family:"Times New Roman",serif;mso-fareast-language:EN-GB">Tel. from abroad:<b><font color="red"><span style="color:red;font-weight:bold">
</span></font></b>0033.369.48.52.78<br>
Tel. inside France: 03.69.48.52.78<br>
websites:<br>
</span></font><a href="https://urldefense.com/v3/__http://www.igbmc.fr/research/department/3/team/36/__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XSOqN342A$"><font color="blue" face="Times New Roman"><span style="font-family:"Times New Roman",serif;color:blue">http://www.igbmc.fr/research/department/3/team/36/</span></font></a><font face="Times New Roman"><span style="font-family:"Times New Roman",serif;mso-fareast-language:EN-GB"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__http://www.igbmc.fr/grandesstructures/cbi/__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XTaEEL8TA$" target="_blank"><font color="blue" face="Times New Roman"><span style="font-family:"Times New Roman",serif;color:blue;mso-fareast-language:EN-GB">http://www.igbmc.fr/grandesstructures/cbi</span></font></a></span></font><font face="Times New Roman"><span style="font-family:"Times New Roman",serif;mso-fareast-language:EN-GB"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__http://frisbi.eu/__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XRYJ30Z6A$" target="_blank"><font color="blue" face="Times New Roman"><span style="font-family:"Times New Roman",serif;color:blue;mso-fareast-language:EN-GB">http://frisbi.eu</span></font></a></span></font><font face="Times New Roman"><span style="font-family:"Times New Roman",serif"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__http://instruct-eric.eu/__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XR09OUpUg$"><font color="blue" face="Times New Roman"><span style="font-family:"Times New Roman",serif;color:blue;mso-fareast-language:EN-GB">http://instruct-eric.eu</span></font></a></span></font><font face="Times New Roman"><span style="font-family:"Times New Roman",serif"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt"><a href="https://urldefense.com/v3/__https://inext-discovery.eu/__;!!Mih3wA!TyRZHeQAJmZ9TV2SW147c82SIN1fRljpgbfWzWVTW56uwI0qjclP3W608XQA_LEvtQ$"><font color="blue" face="Times New Roman"><span style="font-family:"Times New Roman",serif;color:blue">https://inext-discovery.eu</span></font></a></span></font><font face="Times New Roman"><span style="font-family:"Times New Roman",serif"><o:p></o:p></span></font></p>
<p class="MsoNormal"><font size="2" face="Calibri"><span style="font-size:11.0pt"><o:p> </o:p></span></font></p>
</div>
</body>
</html>