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<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
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-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">Dear Researchers, </span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
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text-decoration: none;"><span style="font-size: 11pt; color:
black;"> </span></p>
<p class="xxmsoplaintext" style="margin: 0in 0in 0.0001pt;
font-size: 12pt; font-family: "Times New Roman", serif;
caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-style:
normal; font-variant-caps: normal; font-weight: normal;
letter-spacing: normal; orphans: auto; text-align: start;
text-indent: 0px; text-transform: none; white-space: normal;
widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none;"><span
style="font-size: 11pt; font-family: Calibri, sans-serif; color:
black;">The<span class="apple-converted-space"> </span></span><a href="https://urldefense.com/v3/__https://www.bnl.gov/cryo-em/__;!!Mih3wA!VwTYW0x86E8U4xXJlQIGPsBvKFhq6oCnmKJuZpdkUYKInNP8CPf9XfG5chP1gmGaMw$" style="color: blue;
text-decoration: underline;"><span style="font-size: 11pt;
font-family: Calibri, sans-serif;">Laboratory for BioMolecular
Structure (LBMS)</span></a><span style="font-size: 11pt;
font-family: Calibri, sans-serif; color: black;"><span
class="Apple-converted-space"> </span>at Brookhaven National
Laboratory<span class="apple-converted-space"> </span>is now
accepting general research proposals through an<span
class="apple-converted-space"> </span>open proposal process.<span
class="Apple-converted-space"> </span></span></p>
<p class="xxmsoplaintext" style="margin: 0in 0in 0.0001pt;
font-size: 12pt; font-family: "Times New Roman", serif;
caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-style:
normal; font-variant-caps: normal; font-weight: normal;
letter-spacing: normal; orphans: auto; text-align: start;
text-indent: 0px; text-transform: none; white-space: normal;
widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none;"><span
style="font-size: 11pt; font-family: Calibri, sans-serif; color:
black;"> </span></p>
<p class="xxmsoplaintext" style="margin: 0in 0in 0.0001pt;
font-size: 12pt; font-family: "Times New Roman", serif;
caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-style:
normal; font-variant-caps: normal; font-weight: normal;
letter-spacing: normal; orphans: auto; text-align: start;
text-indent: 0px; text-transform: none; white-space: normal;
widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none;"><span
style="font-size: 11pt; font-family: Calibri, sans-serif; color:
black;">This new, state-of-the-art research center offers
scientists access to<span class="Apple-converted-space"> </span></span><a href="https://urldefense.com/v3/__https://www.bnl.gov/cryo-em/instrumentation.php__;!!Mih3wA!VwTYW0x86E8U4xXJlQIGPsBvKFhq6oCnmKJuZpdkUYKInNP8CPf9XfG5chNUCaJLyA$" title="https://www.bnl.gov/cryo-em/instrumentation.php" style="color: blue; text-decoration: underline;"><span
style="font-size: 11pt; font-family: Calibri, sans-serif;">advanced
cryo-electron microscopes</span></a><span style="font-size:
11pt; font-family: Calibri, sans-serif; color: black;"><span
class="Apple-converted-space"> </span>(cryo-EMs) for single
particle analysis of proteins and macromolecular complexes, as
well as cryo-electron tomography (cryo-ET) of cells and tissues.<span
class="apple-converted-space"> </span></span><span
class="apple-converted-space"></span></p>
<p class="xxmsoplaintext" style="margin: 0in 0in 0.0001pt;
font-size: 12pt; font-family: "Times New Roman", serif;
caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-style:
normal; font-variant-caps: normal; font-weight: normal;
letter-spacing: normal; orphans: auto; text-align: start;
text-indent: 0px; text-transform: none; white-space: normal;
widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none;"><span
class="apple-converted-space"><span style="font-size: 11pt;
font-family: Calibri, sans-serif; color: black;"> </span></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">LBMS operates in two 6-month cycles and all electron
microscope (EM) time is requested each cycle through the
web-based<span class="Apple-converted-space"> </span></span><a href="https://urldefense.com/v3/__https://pass.bnl.gov/__;!!Mih3wA!VwTYW0x86E8U4xXJlQIGPsBvKFhq6oCnmKJuZpdkUYKInNP8CPf9XfG5chPK5o3kmQ$" title="https://pass.bnl.gov/" style="color: blue; text-decoration: underline;"><span
style="font-size: 11pt;">Proposal Allocation, Safety, and
Scheduling System (PASS)</span></a><span style="font-size:
11pt; color: black;"><span class="Apple-converted-space"> </span>system.
There are a number of modes of access for cryo-EMs at LBMS
including General User, Rapid Access, and Block Allocation
Groups</span><span style="font-size: 11pt;"><span
class="Apple-converted-space"> </span><span style="color:
black;">that all follow a common life cycle that involves the
following steps: proposal submission, feasibility evaluation,
peer-review, allocation of EM time, scheduling, carrying out
the work, and reporting the results. To start, you need to
identify the type of proposal, the technique, and the
microscope that fits your needs. For more details, see the<span
class="Apple-converted-space"> </span></span></span><a href="https://urldefense.com/v3/__https://www.bnl.gov/cryo-em/userguide/__;!!Mih3wA!VwTYW0x86E8U4xXJlQIGPsBvKFhq6oCnmKJuZpdkUYKInNP8CPf9XfG5chO4jrlXtw$" style="color:
blue; text-decoration: underline;"><span style="font-size:
11pt;">LBMS User Guide</span></a><span style="font-size: 11pt;
color: black;">.</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;"> </span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
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-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><b><span style="font-size: 11pt; color:
black;">Given the uncertainties with onsite EM operations for
the January – June (2021-1) cycle, all proposals must provide
a remote access plan.</span></b><span style="font-size: 11pt;
color: black;"></span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;"> </span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">The deadline for proposals for the 2021-1 cycle at LBMS
is </span><b><span style="font-size: 11pt; color: red;">Wednesday,
September 30, 2020 at 11:59 pm New York time</span></b><span
style="font-size: 11pt; color: black;">. If you feel you may
need help during the submission process, please create your
proposal as early as possible. Please note the<span
class="Apple-converted-space"> </span></span><a href="https://urldefense.com/v3/__https://www.bnl.gov/ps/users/administration.php__;!!Mih3wA!VwTYW0x86E8U4xXJlQIGPsBvKFhq6oCnmKJuZpdkUYKInNP8CPf9XfG5chM6AghOXQ$" style="color: blue; text-decoration: underline;"><span
style="font-size: 11pt;">User Services Office</span></a><span
style="font-size: 11pt; color: black;"><span
class="Apple-converted-space"> </span>will be available until
5:00 pm that day. </span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;"> </span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">For instructions on how to submit proposals, see the<span
class="Apple-converted-space"> </span></span><a href="https://urldefense.com/v3/__https://www.bnl.gov/cryo-em/userguide/__;!!Mih3wA!VwTYW0x86E8U4xXJlQIGPsBvKFhq6oCnmKJuZpdkUYKInNP8CPf9XfG5chO4jrlXtw$" style="color:
blue; text-decoration: underline;"><span style="font-size:
11pt;">LBMS User Guide</span></a><span style="font-size: 11pt;
color: black;">. </span><span style="font-size: 11pt; color:
rgb(32, 32, 32);">For questions regarding the LBMS facility,
please contact Liguo Wang at<span class="apple-converted-space"> </span></span><a
href="mailto:lbms-em@bnl.gov" title="mailto:lbms-em@bnl.gov"
style="color: blue; text-decoration: underline;"><span
style="font-size: 11pt;">lbms-em@bnl.gov</span></a><span
style="font-size: 11pt; color: rgb(32, 32, 32);">.</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
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-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;"> </span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
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-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">We look forward to working with you during these
exciting early years of LBMS operations!</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
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text-decoration: none;"><span style="font-size: 11pt; color:
black;"><br>
</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
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text-decoration: none;"><span style="font-size: 11pt; color:
black;"><br>
</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">LBMS</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
white-space: normal; widows: auto; word-spacing: 0px;
-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">Brookhaven National Laboratory <br>
</span></p>
<p class="MsoNormal" style="margin: 0in 0in 0.0001pt; font-size:
12pt; font-family: Calibri, sans-serif; caret-color: rgb(0, 0, 0);
color: rgb(0, 0, 0); font-style: normal; font-variant-caps:
normal; font-weight: normal; letter-spacing: normal; orphans:
auto; text-align: start; text-indent: 0px; text-transform: none;
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-webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px;
text-decoration: none;"><span style="font-size: 11pt; color:
black;">Upton, NY 11738<br>
</span></p>
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