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<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
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-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: Calibri, sans-serif;"><span style="font-size:
11pt; color: black;">Dear Researchers, </span></p>
<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
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12pt; font-family: Calibri, sans-serif;"><span style="font-size:
11pt; color: black;"> </span></p>
<p class="x_xxmsoplaintext" style="margin: 0in 0in 0.0001pt;
caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-style:
normal; font-variant-caps: normal; font-weight: normal;
letter-spacing: normal; orphans: auto; text-align: start;
text-indent: 0px; text-transform: none; white-space: normal;
widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: "Times New Roman", serif;"><span
style="font-size: 11pt; font-family: Calibri, sans-serif; color:
black;">The<span class="x_apple-converted-space"> </span></span><a href="https://urldefense.com/v3/__https://www.bnl.gov/cryo-em/__;!!Mih3wA!WkBXyvOQ9OlEP4c9FXCITzjI2CCQedupqmGwU5KX03JmkCsFqef21b4paFwDZJ6rhA$"><span style="font-size:
11pt; font-family: Calibri, sans-serif;">Laboratory for
BioMolecular Structure (LBMS)</span></a><span
style="font-size: 11pt; font-family: Calibri, sans-serif; color:
black;"><span class="Apple-converted-space"> </span>at
Brookhaven National Laboratory<span
class="x_apple-converted-space"> </span>is now accepting
general research proposals through an<span
class="x_apple-converted-space"> </span>open proposal process.<span
class="Apple-converted-space"> </span></span></p>
<p class="x_xxmsoplaintext" style="margin: 0in 0in 0.0001pt;
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text-indent: 0px; text-transform: none; white-space: normal;
widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: "Times New Roman", serif;"><span
style="font-size: 11pt; font-family: Calibri, sans-serif; color:
black;"> </span></p>
<p class="x_xxmsoplaintext" style="margin: 0in 0in 0.0001pt;
caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-style:
normal; font-variant-caps: normal; font-weight: normal;
letter-spacing: normal; orphans: auto; text-align: start;
text-indent: 0px; text-transform: none; white-space: normal;
widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto;
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12pt; font-family: "Times New Roman", serif;"><span
style="font-size: 11pt; font-family: Calibri, sans-serif; color:
black;">This new, state-of-the-art research center offers
scientists access to<span class="Apple-converted-space"> </span></span><a href="https://urldefense.com/v3/__https://www.bnl.gov/cryo-em/instrumentation.php__;!!Mih3wA!WkBXyvOQ9OlEP4c9FXCITzjI2CCQedupqmGwU5KX03JmkCsFqef21b4paFw1SGNFzA$"><span
style="font-size: 11pt; font-family: Calibri, sans-serif;">advanced
cryo-electron microscopes</span></a><span style="font-size:
11pt; font-family: Calibri, sans-serif; color: black;"><span
class="Apple-converted-space"> </span>(cryo-EMs) for single
particle analysis of proteins and macromolecular complexes, as
well as cryo-electron tomography (cryo-ET) of cells and tissues.<span
class="x_apple-converted-space"> </span></span><span
class="x_apple-converted-space"></span></p>
<p class="x_xxmsoplaintext" style="margin: 0in 0in 0.0001pt;
caret-color: rgb(0, 0, 0); color: rgb(0, 0, 0); font-style:
normal; font-variant-caps: normal; font-weight: normal;
letter-spacing: normal; orphans: auto; text-align: start;
text-indent: 0px; text-transform: none; white-space: normal;
widows: auto; word-spacing: 0px; -webkit-text-size-adjust: auto;
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12pt; font-family: "Times New Roman", serif;"><span
class="x_apple-converted-space"><span style="font-size: 11pt;
font-family: Calibri, sans-serif; color: black;"> </span></span></p>
<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
normal; orphans: auto; text-align: start; text-indent: 0px;
text-transform: none; white-space: normal; widows: auto;
word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: Calibri, sans-serif;"><span style="font-size:
11pt; color: black;">LBMS operates in two 6-month cycles and all
electron microscope (EM) time is requested each cycle through
the web-based<span class="Apple-converted-space"> </span></span><a href="https://urldefense.com/v3/__https://pass.bnl.gov/__;!!Mih3wA!WkBXyvOQ9OlEP4c9FXCITzjI2CCQedupqmGwU5KX03JmkCsFqef21b4paFwtdRvw9w$"><span style="font-size: 11pt;">Proposal
Allocation, Safety, and Scheduling System (PASS)</span></a><span
style="font-size: 11pt; color: black;">system. There are a
number of<span class="Apple-converted-space"> </span></span><span
style="font-size: 11pt; color: black;">modes of access</span><span
style="font-size: 11pt; color: black;"><span
class="Apple-converted-space"> </span>for cryo-EMs at LBMS
including General User, Rapid Access, and Block Allocation
Groups</span><span style="font-size: 11pt;"><span
class="Apple-converted-space"> </span></span><span
style="font-size: 11pt; color: black;">that all follow a common
life cycle that involves the following steps: proposal
submission, feasibility evaluation, peer-review, allocation of
EM time, scheduling, carrying out the work, and reporting the
results. To start, you need to identify the type of proposal,
the technique, and the microscope that fits your needs. For
more details, see the<span class="Apple-converted-space"> </span></span><a href="https://urldefense.com/v3/__https://www.bnl.gov/cryo-em/userguide/__;!!Mih3wA!WkBXyvOQ9OlEP4c9FXCITzjI2CCQedupqmGwU5KX03JmkCsFqef21b4paFydIY-PSg$"><span
style="font-size: 11pt;">LBMS User Guide</span></a><span
style="font-size: 11pt; color: black;">.</span></p>
<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
normal; orphans: auto; text-align: start; text-indent: 0px;
text-transform: none; white-space: normal; widows: auto;
word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: Calibri, sans-serif;"><span style="font-size:
11pt; color: black;"> </span></p>
<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
normal; orphans: auto; text-align: start; text-indent: 0px;
text-transform: none; white-space: normal; widows: auto;
word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: Calibri, sans-serif;"><b><span
style="font-size: 11pt; color: black;">Given the uncertainties
with onsite EM operations for the January – June (2021-1)
cycle, all proposals must provide a remote access plan.</span></b><span
style="font-size: 11pt; color: black;"></span></p>
<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
normal; orphans: auto; text-align: start; text-indent: 0px;
text-transform: none; white-space: normal; widows: auto;
word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: Calibri, sans-serif;"><span style="font-size:
11pt; color: black;"> </span></p>
<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
normal; orphans: auto; text-align: start; text-indent: 0px;
text-transform: none; white-space: normal; widows: auto;
word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: Calibri, sans-serif;"><span style="font-size:
11pt; color: black;">The deadline for proposals for the 2021-1
cycle at LBMS is </span><b><span style="font-size: 11pt; color:
red;">Wednesday, September 30, 2020 at 11:59 pm New York time</span></b><span
style="font-size: 11pt; color: black;">. If you feel you may
need help during the submission process, please create your
proposal as early as possible. Please note the<span
class="Apple-converted-space"> </span></span><a href="https://urldefense.com/v3/__https://www.bnl.gov/ps/users/administration.php__;!!Mih3wA!WkBXyvOQ9OlEP4c9FXCITzjI2CCQedupqmGwU5KX03JmkCsFqef21b4paFwrGY2bhw$"><span
style="font-size: 11pt;">User Services Office</span></a><span
style="font-size: 11pt; color: black;"><span
class="Apple-converted-space"> </span>will be available until
5:00 pm that day. </span></p>
<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
normal; orphans: auto; text-align: start; text-indent: 0px;
text-transform: none; white-space: normal; widows: auto;
word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: Calibri, sans-serif;"><span style="font-size:
11pt; color: black;"> </span></p>
<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
normal; orphans: auto; text-align: start; text-indent: 0px;
text-transform: none; white-space: normal; widows: auto;
word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: Calibri, sans-serif;"><span style="font-size:
11pt; color: black;">For instructions on how to submit
proposals, see the<span class="Apple-converted-space"> </span></span><a href="https://urldefense.com/v3/__https://www.bnl.gov/cryo-em/userguide/__;!!Mih3wA!WkBXyvOQ9OlEP4c9FXCITzjI2CCQedupqmGwU5KX03JmkCsFqef21b4paFydIY-PSg$"><span
style="font-size: 11pt;">LBMS User Guide</span></a><span
style="font-size: 11pt; color: black;">. </span><span
style="font-size: 11pt; color: rgb(32, 32, 32);">For questions
regarding the LBMS facility, please contact Liguo Wang at<span
class="x_apple-converted-space"> </span></span><a
href="mailto:lbms-em@bnl.gov" title="mailto:lbms-em@bnl.gov"><span
style="font-size: 11pt;">lbms-em@bnl.gov</span></a><span
style="font-size: 11pt; color: rgb(32, 32, 32);">.</span></p>
<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
normal; orphans: auto; text-align: start; text-indent: 0px;
text-transform: none; white-space: normal; widows: auto;
word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: Calibri, sans-serif;"><span style="font-size:
11pt; color: black;"> </span></p>
<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
normal; orphans: auto; text-align: start; text-indent: 0px;
text-transform: none; white-space: normal; widows: auto;
word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: Calibri, sans-serif;"><span style="font-size:
11pt; color: black;">We look forward to working with you during
these exciting early years of LBMS operations!</span></p>
<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
rgb(0, 0, 0); color: rgb(0, 0, 0); font-style: normal;
font-variant-caps: normal; font-weight: normal; letter-spacing:
normal; orphans: auto; text-align: start; text-indent: 0px;
text-transform: none; white-space: normal; widows: auto;
word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: Calibri, sans-serif;"><span style="font-size:
11pt; color: black;"><br>
</span></p>
<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
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word-spacing: 0px; -webkit-text-size-adjust: auto;
-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: Calibri, sans-serif;"><span style="font-size:
11pt; color: black;">LBMS</span></p>
<span style="font-size: 11pt; color: black;">Brookhaven National
Laboratory</span><br>
<span style="font-size: 11pt; color: black;"></span>
<p class="x_MsoNormal" style="margin: 0in 0in 0.0001pt; caret-color:
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-webkit-text-stroke-width: 0px; text-decoration: none; font-size:
12pt; font-family: Calibri, sans-serif;"><span style="font-size:
11pt; color: black;">Upton, NY 11973<br>
</span></p>
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