<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div class="" style="orphans: 2; widows: 2; box-sizing: border-box; margin: 0px 0px 10px; font-variant-ligatures: normal;"><b class="">Dear all!! Wish you a lovely weekend, and just remind you about a postdoc fellowship/position, open for application until 19th August, so take the change to apply and join the Integrated Structure Biology groups <a href="https://urldefense.com/v3/__https://www.biostruct.umu.se/__;!!Mih3wA!WeWSOWIFeTK8nL7aBwVKEz6tLlRwOAAdFWAuJ6yVkpr5XJSbpZSQryuu7vXEzLiaVA$" class="">https://www.biostruct.umu.se/</a></b><b class=""> at Umeå University, north Sweden in a interesting collaboration with Luca Jovines Lab at Karolinska institutet:</b></div><div class="" style="orphans: 2; widows: 2; box-sizing: border-box; margin: 0px 0px 10px; font-variant-ligatures: normal;"><b class="">Structural dynamics of the egg coat at fertilization by cryo-ET</b></div><div class="" style="orphans: 2; widows: 2; box-sizing: border-box; margin: 0px 0px 10px; font-variant-ligatures: normal;">The aim of this project will be to shed light on fertilization by using cryo-ET to image different stages of interaction between gametes. By imaging frozen-hydrated samples, we will focus on resolving the overall architecture of the mammalian zona pellucida and related egg coats, as well as investigating how changes in the structure of these extracellular matrices contribute to the block to polyspermy.</div><div class="" style="orphans: 2; widows: 2; box-sizing: border-box; margin: 0px 0px 10px; font-variant-ligatures: normal;">The project will be carried out in close collaboration with Luca Jovine <a href="https://urldefense.com/v3/__http://jovinelab.org/__;!!Mih3wA!WeWSOWIFeTK8nL7aBwVKEz6tLlRwOAAdFWAuJ6yVkpr5XJSbpZSQryuu7vUhLAf8Qg$" class="">http://jovinelab.org</a> and <a href="https://urldefense.com/v3/__https://www.umu.se/en/staff/linda-sandblad/__;!!Mih3wA!WeWSOWIFeTK8nL7aBwVKEz6tLlRwOAAdFWAuJ6yVkpr5XJSbpZSQryuu7vXsFD4HmA$" class="">Linda Sandblad</a> at Umeå University associated with the <a href="https://urldefense.com/v3/__https://www.umu.se/en/research/infrastructure/umea-core-facility-for-electron-microscopy-ucem/__;!!Mih3wA!WeWSOWIFeTK8nL7aBwVKEz6tLlRwOAAdFWAuJ6yVkpr5XJSbpZSQryuu7vXyrfmb6g$" class="">Umeå Core facility for Electron Microscopy (UCEM)</a> The position will be located in the <a href="https://urldefense.com/v3/__https://www.umu.se/en/chemical-biological-centre/__;!!Mih3wA!WeWSOWIFeTK8nL7aBwVKEz6tLlRwOAAdFWAuJ6yVkpr5XJSbpZSQryuu7vWQNZESaA$" class="">Chemical Biological Centre (KBC) building at Umeå University</a>, but may also require short visits at our KI laboratory.</div><div class="" style="orphans: 2; widows: 2; box-sizing: border-box; margin: 0px 0px 10px; font-variant-ligatures: normal;">Available for the project are a TFS Titan Krios instrument with K2 BioQuantum detector, a Scios DualBeam SEM with Aquilos-upgraded cryo-FIB and a Leica Thunder fluorescence microscope with cryo-stage, as well as full access to all additional instruments and sample preparation equipment at both UCEM and Biochemical Imaging Centre Umeå (BICU).</div><div class="" style="orphans: 2; widows: 2; box-sizing: border-box; margin: 0px 0px 10px; font-variant-ligatures: normal;">Qualified applicants should have a Ph.D. degree (or be about to receive one), at least one first-author publication in a high-quality international peer-reviewed journal and documented experience in biochemistry and cryo-EM, together with strong computational skills as well as good knowledge of developmental biology. Candidates must be able to carry out independent scientific research work and to write scientific reports and manuscripts. Fluency in written and spoken English is essential. Emphasis will be placed on personal suitability, organizational skills and ability to collaborate with other members of the lab and the EM facility staff, as well as on genuine enthusiasm for the research area and methodology.</div><div class="" style="orphans: 2; widows: 2; box-sizing: border-box; margin: 0px 0px 10px; font-variant-ligatures: normal;">For more information about this position, please send an e-mail to <a href="mailto:luca.jovine@ki.se" class="">luca.jovine@ki.se</a> and <a href="mailto:linda.sandblad@umu.se" class="">linda.sandblad@umu.se</a>. To apply, please use the following link (deadline 19 August 2020):</div><div class="" style="orphans: 2; widows: 2; box-sizing: border-box; margin: 0px 0px 10px; font-variant-ligatures: normal;"><a href="https://urldefense.com/v3/__https://www.umu.se/en/work-with-us/fellowships-and-grants/6-1250-20__;!!Mih3wA!WeWSOWIFeTK8nL7aBwVKEz6tLlRwOAAdFWAuJ6yVkpr5XJSbpZSQryuu7vXswI-gGg$" class="">https://www.umu.se/en/work-with-us/fellowships-and-grants/6-1250-20</a></div><div class="" style="orphans: 2; widows: 2; box-sizing: border-box; margin: 0px 0px 10px; font-variant-ligatures: normal;"><br class=""></div><div class="" style="orphans: 2; widows: 2; box-sizing: border-box; margin: 0px 0px 10px; font-variant-ligatures: normal;">Best regards Linda</div><div class="" style="orphans: 2; widows: 2; box-sizing: border-box; margin: 0px 0px 10px; font-variant-ligatures: normal;">Linda Sandblad, researcher and facility director</div><div class=""><div dir="auto" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div dir="auto" style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><div>Umeå Core Facility for Electron Microscopy, SciLifeLab Cryo-EM, NMI<br class="">Department of Chemistry, Umeå University, Sweden<br class="">Tel: +46 709324936</div><div class=""><br class=""></div></div></div></div></div></div></body></html>