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Dear EM-ers,<br>
<div class="moz-forward-container"> <br>
I was asked about this today, so I just thought I'd confirm the
below explicitly. <span class="css-901oao css-16my406 r-1qd0xha
r-ad9z0x r-bcqeeo r-qvutc0">Please note that I'm not a lawyer,
so none of this message should be taken as legal advice. </span><br>
<br>
RELION is also <span class="css-901oao css-16my406 r-1qd0xha
r-ad9z0x r-bcqeeo r-qvutc0">free for commercial use. </span><span
class="css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo
r-qvutc0"><span class="css-901oao css-16my406 r-1qd0xha r-ad9z0x
r-bcqeeo r-qvutc0"><br>
</span><br>
For now, there is one caveat because of a patent </span><span
class="css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo
r-qvutc0">held by Structura Biotechnology, the company that
makes cryoSPARC. In the hope that it is useful for US-based
commercial users, </span><span class="css-901oao css-16my406
r-1qd0xha r-ad9z0x r-bcqeeo r-qvutc0"></span><span
class="css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo
r-qvutc0"><span class="css-901oao css-16my406 r-1qd0xha r-ad9z0x
r-bcqeeo r-qvutc0">I copy a previous message to the CCP-EM
mailing list with more details below.<br>
</span></span><br>
<span class="css-901oao css-16my406 r-1qd0xha r-ad9z0x r-bcqeeo
r-qvutc0"><span class="css-901oao css-16my406 r-1qd0xha r-ad9z0x
r-bcqeeo r-qvutc0"></span>Best wishes,<br>
Sjors<br>
<br>
<br>
--<br>
<br>
<br>
<br>
</span>Dear RELION users,<br>
<br>
We are not lawyers, so none of this message should be taken as
legal advice.<br>
<br>
We have changed the terms of the GPLv2 license under which RELION
is distributed. Please find the modified part (in section 8)
below. Academic users or commercial users outside the USA are not
affected by this change, but if you wish to use RELION in the USA
with the SAGD method in conjunction with a modulation by a
contrast transfer function of the particle images for ab-initio
single-particle reconstruction, non-profit academic research uses
are freely licensed under the terms of the license agreement
available at <a href="https://urldefense.com/v3/__https://cryosparc.com/patent-faqs__;!!Mih3wA!SaAVg-T2aKXTkxiqxuavPMEdCFVekCCRWmQQN2F6VGz2TdQezeWWGtZTiqGKmwuHFw$" target="_blank" moz-do-not-send="true">https://cryosparc.com/patent-faqs</a>.
Alternatively, commercial users in the USA may want to consider
downloading the latest version from github and rebuilding RELION
with the cmake option -DALLOW_CTF_IN_SAGD=OFF, which disables the
SAGD method in conjunction with a modulation by a contrast
transfer function of the particle images for ab-initio
single-particle reconstruction.<br>
<br>
Please note that we do not take lightly the disabling of useful
functionality from RELION. Because we consider that RELION was
built upon foundations that were laid by many in the field before
us, we feel strongly that it should remain free to use and further
built upon by anyone in the field, regardless of their location
and whether they are involved in commercial activities or not. We
believe that the field's rapid growth has benefited from its
traditions of sharing and openness, and hope this will remain the
case as the field continues to expand and new players continue to
join.<br>
<br>
Best regards,<br>
<br>
Sjors, Erik, Takanori, Jasenko & Dari<br>
<br>
--<br>
<br>
New text to section 8 of the GPLv2:<br>
<br>
This version of RELION uses a stochastic average gradient descent
(SAGD) method in conjunction with a modulation by a contrast
transfer function of the particle images for ab-initio
single-particle reconstruction.<br>
<br>
Should you wish to use RELION with the SAGD method in conjunction
with a modulation by a contrast transfer function of the particle
images for ab-initio single-particle reconstruction, please note
that this functionality may be covered in the USA by US Patent No.
10,282,513. Non-profit academic research uses of the patented IP
are freely licensed under the terms of the license agreement
available at<a href="https://urldefense.com/v3/__https://cryosparc.com/patent-faqs__;!!Mih3wA!SaAVg-T2aKXTkxiqxuavPMEdCFVekCCRWmQQN2F6VGz2TdQezeWWGtZTiqGKmwuHFw$" target="_blank" moz-do-not-send="true">https://cryosparc.com/patent-faqs</a>.<br>
<br>
Should you wish to use RELION without modulation by a contrast
transfer function of the particle images in the SAGD method for
ab-initio single-particle reconstruction, you may disable this
functionality using -DALLOW_CTF_IN_SAGD=OFF at the stage of
configuration, i.e. before compilation of the code.
<pre>
--
Sjors Scheres
MRC Laboratory of Molecular Biology
Francis Crick Avenue, Cambridge Biomedical Campus
Cambridge CB2 0QH, U.K.
tel: +44 (0)1223 267061
<a href="https://urldefense.com/v3/__http://www2.mrc-lmb.cam.ac.uk/groups/scheres__;!!Mih3wA!SaAVg-T2aKXTkxiqxuavPMEdCFVekCCRWmQQN2F6VGz2TdQezeWWGtZTiqHiPVSokA$" target="_blank" moz-do-not-send="true">http://www2.mrc-lmb.cam.ac.uk/groups/scheres</a></pre>
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