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<p class="MsoNormal">Hi Matthijn,<o:p></o:p></p>
<p class="MsoNormal">Even at BSL3 level most of the parts could be returned for repairs, it all depends on decontamination procedure used. And yes, decontamination could harm the equipment, but it should not prevent manufacturer from accepting parts back from
BSL3 lab. As you said, it all depends on the agreement between the lab and the manufacturer. I have first hand experience on that and did not have a problem so far in service of my BSL3 machine. That is true, that service engineers are not allowed to the lab
when it is level 3, but I do not drop the level to 1, but rather to 2 for them to enter. That works perfectly well for both sides. I do not see a big difference in practical terms between level 1 and 2 and engineers feel comfortable working in level 2 lab.
At least in my case, and it is worth noting, that UTMB is pretty strict with biological safety. While your statement that it all depends on local rules is correct, there are general classifications, mostly national, that dictate the safety level and operating
procedures to follow.<o:p></o:p></p>
<p class="MsoNormal">Misha<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<div>
<p class="MsoNormal"><span style="color:black">Michael Sherman, PhD<br>
Dept. of Biochem. & Mol. Biology<br>
1.224 Medical Research Building<br>
Univ. of Texas Medical Branch<br>
Galveston, TX 77555-1055<br>
Tel. 409-772-6310<br>
Fax: 409-772-6299<br>
</span><a href="mailto:mbsherma@UTMB.edu"><span style="color:purple">mbsherma@UTMB.edu</span></a><o:p></o:p></p>
</div>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<div style="border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in">
<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">3dem <3dem-bounces@ncmir.ucsd.edu> on behalf of Matthijn VOS <matthijn.vos@pasteur.fr><br>
<b>Date: </b>Monday, July 6, 2020 at 2:34 AM<br>
<b>To: </b>Sheemei Lok <sheemei.lok@duke-nus.edu.sg><br>
<b>Cc: </b>"3dem@ncmir.ucsd.edu" <3dem@ncmir.ucsd.edu><br>
<b>Subject: </b>Re: [3dem] BSL2 vs BSL1<o:p></o:p></span></p>
</div>
<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div style="border:solid black 1.0pt;padding:2.0pt 2.0pt 2.0pt 2.0pt">
<p class="MsoNormal" style="line-height:12.0pt;background:#FFEB9C"><b><span style="font-size:10.0pt;color:black">WARNING:</span></b><span style="font-size:10.0pt;color:black"> This email originated from outside of UTMB's email system. Do not click links or
open attachments unless you recognize the sender and know the content is safe.<o:p></o:p></span></p>
</div>
<p class="MsoNormal"><o:p> </o:p></p>
<div>
<div>
<p class="MsoNormal">This I do not know, best ask TFS life science business unit either directly or through your local account manager.<o:p></o:p></p>
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<div>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
<div>
<p class="MsoNormal">Cheers<o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><br>
<br>
<o:p></o:p></p>
<blockquote style="margin-top:5.0pt;margin-bottom:5.0pt">
<p class="MsoNormal" style="margin-bottom:12.0pt">On Jul 6, 2020, at 08:41, Sheemei Lok <sheemei.lok@duke-nus.edu.sg> wrote:<o:p></o:p></p>
</blockquote>
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<blockquote style="margin-top:5.0pt;margin-bottom:5.0pt">
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<p class="MsoNormal">How many FEI service centers are there in the world? Can we send the parts to the country with the same BSL classification?<o:p></o:p></p>
<p class="MsoNormal">We have heard the only place is in Netherland and hence the rest of the world (except EU) will be affected.<o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<p class="MsoNormal">Sheemei<o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<div style="border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in">
<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">Sheemei Lok <sheemei.lok@duke-nus.edu.sg><br>
<b>Date: </b>Monday, 6 July 2020 at 2:27 PM<br>
<b>To: </b>Matthijn VOS <matthijn.vos@pasteur.fr>, jamon <jamonshi@gmail.com><br>
<b>Cc: </b>"3dem@ncmir.ucsd.edu" <3dem@ncmir.ucsd.edu><br>
<b>Subject: </b>Re: [3dem] BSL2 vs BSL1</span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"> <o:p></o:p></p>
</div>
<p class="MsoNormal">Thanks Matthjin, how about if there’s a difference in BSL classification between different countries? For example, the rest of the world that particular pathogen is classified as BSL2 agent while in Netherlands, BSL3. Should there be an
increased in maintenance fees?<o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<p class="MsoNormal">Regards,<o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<p class="MsoNormal">Sheemei<o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<p class="MsoNormal" style="text-autospace:none"><span lang="EN-GB" style="font-size:12.0pt;color:black">Shee-Mei Lok</span><o:p></o:p></p>
<p class="MsoNormal" style="text-autospace:none"><span lang="EN-GB" style="font-size:12.0pt;color:black">Professor/National Research Foundation Investigator</span><o:p></o:p></p>
<p class="MsoNormal" style="text-autospace:none"><span lang="EN-GB" style="font-size:12.0pt;color:black">Program in Emerging Infectious Diseases</span><o:p></o:p></p>
<p class="MsoNormal" style="text-autospace:none"><span lang="EN-GB" style="font-size:12.0pt;color:black">Duke-NUS Medical School</span><o:p></o:p></p>
<p class="MsoNormal" style="text-autospace:none"><span lang="EN-GB" style="font-size:12.0pt;color:black">KTP Building</span><o:p></o:p></p>
<p class="MsoNormal" style="text-autospace:none"><span lang="EN-GB" style="font-size:12.0pt;color:black">Level 9 </span><o:p></o:p></p>
<p class="MsoNormal" style="text-autospace:none"><span lang="EN-GB" style="font-size:12.0pt;color:black">8 college Road</span><o:p></o:p></p>
<p class="MsoNormal" style="text-autospace:none"><span lang="EN-GB" style="font-size:12.0pt;color:black">Singapore 169857</span><o:p></o:p></p>
<p class="MsoNormal" style="text-autospace:none"><span lang="EN-GB" style="font-size:12.0pt;color:black">Ph:65-65165840
</span><o:p></o:p></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;font-family:"Times New Roman",serif;color:black"> </span><o:p></o:p></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;color:black">Professor/Principal Investigator</span><o:p></o:p></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;color:black">Center for BioImaging Sciences</span><o:p></o:p></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;color:black">Department of Biological Sciences</span><o:p></o:p></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;color:black">National University of Singapore</span><o:p></o:p></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:12.0pt;color:black">Singapore</span><o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<div style="border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in">
<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">3dem <3dem-bounces@ncmir.ucsd.edu> on behalf of Matthijn VOS <matthijn.vos@pasteur.fr><br>
<b>Date: </b>Monday, 6 July 2020 at 1:53 PM<br>
<b>To: </b>jamon <jamonshi@gmail.com><br>
<b>Cc: </b>"3dem@ncmir.ucsd.edu" <3dem@ncmir.ucsd.edu><br>
<b>Subject: </b>Re: [3dem] BSL2 vs BSL1</span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"> <o:p></o:p></p>
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<table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" width="100%" style="width:100.0%;background:#FFE9E9;border-collapse:collapse">
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<p class="MsoNormal"> <o:p></o:p></p>
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<p class="MsoNormal"><span style="font-size:10.0pt;color:black">- External Email -</span><o:p></o:p></p>
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<p> <o:p></o:p></p>
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<div>
<p class="MsoNormal">Maybe this helps<o:p></o:p></p>
</div>
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<p class="MsoNormal"> <o:p></o:p></p>
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<div>
<p class="MsoNormal"><a href="https://urldefense.com/v3/__https://nam11.safelinks.protection.outlook.com/?url=https*3A*2F*2Furldefense.com*2Fv3*2F__https*3A*2Fconsteril.com*2Fbiosafety-levels-difference*2F__*3B!!Mih3wA!XBbjyfi0Xo0lQGQ95joxA2DQP_Vfnq58ibMOr6C_s9FMgYf9OkoPYLvt9vuqsn35Fg*24&data=02*7C01*7Cmbsherma*40utmb.edu*7C6d9a01ac277d48928d9508d8217f0405*7C7bef256d85db4526a72d31aea2546852*7C0*7C0*7C637296176714740565&sdata=x4cYeGYxLmOV*2Fyp5MfnoHq*2Be03rV2Efvie1HqnzCI9c*3D&reserved=0__;JSUlJSUlJSUlJSUlJSUlJSUlJSUlJQ!!Mih3wA!UXYCafQxStQ9HWrX1t5dbJkop9riR2Zd9aIcZ3yTlxe6JfEgf7AdAGXCbZCSVEnlEw$">https://consteril.com/biosafety-levels-difference/</a><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"> <o:p></o:p></p>
</div>
<div>
<p class="MsoNormal">The difference in lab setup between BSL 1 and 2 are not that big. A lab manager can also decide to declare a lab BSL2 for a period of time, then decontaminate and resume operation as BSL1. TFS only charges extra service cost if microscope
decontamination procedures are involved and parts can not be taken back. In BSL3 all parts stay in the facility until the lab closes. This means a company can not recover parts and reuse them. This will increase cost. Also decontamination procedures might
damage certain parts that need to be replaced (other than the broken parts that needed fixing), which again increases cost. For BSL2 this does all not apply. Wearing lab coats, gloves, presence of a sink, ways to dispose of infectious material, a safety cabinet
and modifications to the air flow I believe are required but are all “reversible” back to BSL1. There are no specifications based on disinfecting the inside of the microscope. Best is to contact your local TFS agent, they have a full unit for dealing with
this, there are many BSL2 facilities worldwide that house EM.<o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"> <o:p></o:p></p>
</div>
<div>
<p class="MsoNormal">Cheers<o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><br>
<br>
<br>
<br>
<o:p></o:p></p>
<blockquote style="margin-top:5.0pt;margin-bottom:5.0pt">
<p class="MsoNormal" style="margin-bottom:12.0pt">On Jul 6, 2020, at 04:21, jamon <jamonshi@gmail.com> wrote:<o:p></o:p></p>
</blockquote>
</div>
<blockquote style="margin-top:5.0pt;margin-bottom:5.0pt">
<div>
<p>I heard there will be ~10% increase of service contract from BSL1 to BSL2. Has it been applied world wide?
<o:p></o:p></p>
<p>Regards,<o:p></o:p></p>
<p>Jian<o:p></o:p></p>
<div>
<p class="MsoNormal">On 6/7/20 9:21 am, Sherman, Michael B. wrote:<o:p></o:p></p>
</div>
<blockquote style="margin-top:5.0pt;margin-bottom:5.0pt">
<p class="MsoNormal">Hi Ruben,<o:p></o:p></p>
<p class="MsoNormal">Jaap is correct, BSL2 assumes standard lab practice, lab coat, gloves at the most, but no special safety/decon procedures. And no service cost increase. TFS does not want to deal with BSL3, so that is out of question. Our Krios is classified
by TFS as level 2 instrument and my engineers come and go as they like (face mask is required currently… for a different reason). I do not see any cosequences declaring your microscope s BSL2.<o:p></o:p></p>
<p class="MsoNormal">All the best,<o:p></o:p></p>
<p class="MsoNormal">Misha<o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<div>
<p class="MsoNormal"><span style="color:black">Michael Sherman, PhD<br>
Dept. of Biochem. & Mol. Biology<br>
1.224 Medical Research Building<br>
Univ. of Texas Medical Branch<br>
Galveston, TX 77555-1055<br>
Tel. 409-772-6310<br>
Fax: 409-772-6299<br>
</span><a href="mailto:mbsherma@UTMB.edu"><span style="color:purple">mbsherma@UTMB.edu</span></a><o:p></o:p></p>
</div>
<p class="MsoNormal"> <o:p></o:p></p>
<p class="MsoNormal"> <o:p></o:p></p>
<div style="border:none;border-top:solid #B5C4DF 1.0pt;padding:3.0pt 0in 0in 0in">
<p class="MsoNormal"><b><span style="font-size:12.0pt;color:black">From: </span></b><span style="font-size:12.0pt;color:black">3dem
<a href="mailto:3dem-bounces@ncmir.ucsd.edu"><3dem-bounces@ncmir.ucsd.edu></a> on behalf of Jaap Brink
<a href="mailto:jbrink@jeol.com"><jbrink@jeol.com></a><br>
<b>Date: </b>Sunday, July 5, 2020 at 8:10 PM<br>
<b>To: </b>Ruben Diaz <a href="mailto:pindusito@gmail.com"><pindusito@gmail.com></a><br>
<b>Cc: </b><a href="mailto:3dem@ncmir.ucsd.edu">"3dem@ncmir.ucsd.edu"</a> <a href="mailto:3dem@ncmir.ucsd.edu">
<3dem@ncmir.ucsd.edu></a><br>
<b>Subject: </b>Re: [3dem] BSL2 vs BSL1</span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"> <o:p></o:p></p>
</div>
<div style="border:solid black 1.0pt;padding:2.0pt 2.0pt 2.0pt 2.0pt">
<p class="MsoNormal" style="line-height:12.0pt;background:#FFEB9C"><b><span style="font-size:10.0pt;color:black">WARNING:</span></b><span style="font-size:10.0pt;color:black"> This email originated from outside of UTMB's email system. Do not click links or
open attachments unless you recognize the sender and know the content is safe.</span><o:p></o:p></p>
</div>
<p class="MsoNormal"> <o:p></o:p></p>
<div>
<p class="MsoNormal" style="margin-bottom:12.0pt">Forgot to add that before SVC enters the facility, a wipe down is required. Akin to what you’d do with a lab bench. <o:p></o:p></p>
<div>
<div>
<p class="MsoNormal">Regards,<o:p></o:p></p>
</div>
<p class="MsoNormal">Jaap <o:p></o:p></p>
<div>
<p class="MsoNormal">---- <o:p></o:p></p>
<div>
<p class="MsoNormal">Jacob Brink <span style="font-size:13.0pt">Ph.D.</span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:13.0pt">TEM Product Manager Life Sciences</span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><b><span style="font-size:13.0pt">JEOL USA, Inc.,</span></b><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:13.0pt">Peabody MA 01960, U.S.A.</span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:13.0pt">Cell: +1 (978) 317-9561</span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"> <o:p></o:p></p>
</div>
<div>
<p class="MsoNormal">Sent from a mobile device. Please excuse typos and this email’s brevity.<o:p></o:p></p>
</div>
</div>
</div>
<div>
<p class="MsoNormal"><br>
<br>
<br>
<br>
<br>
<o:p></o:p></p>
<blockquote style="margin-top:5.0pt;margin-bottom:5.0pt">
<p class="MsoNormal" style="margin-bottom:12.0pt">On Jul 5, 2020, at 8:07 PM, Jaap Brink
<a href="mailto:jbrink@jeol.com"><jbrink@jeol.com></a> wrote:<o:p></o:p></p>
</blockquote>
</div>
<blockquote style="margin-top:5.0pt;margin-bottom:5.0pt">
<div>
<p class="MsoNormal">Hi Ruben, <o:p></o:p></p>
<div>
<p class="MsoNormal"> <o:p></o:p></p>
</div>
<div>
<p class="MsoNormal" style="margin-bottom:12.0pt">Don’t think BSL2 requires that. BSL3 for sure does and requires elaborate decon procedures to be in place. UTMB goes for a SVC visit back from level 3 to level 2. It is then safe to enter. <o:p></o:p></p>
<div>
<div>
<p class="MsoNormal">Regards,<o:p></o:p></p>
</div>
<p class="MsoNormal">Jaap <o:p></o:p></p>
<div>
<p class="MsoNormal">---- <o:p></o:p></p>
<div>
<p class="MsoNormal">Jacob Brink <span style="font-size:13.0pt">Ph.D.</span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:13.0pt">TEM Product Manager Life Sciences</span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><b><span style="font-size:13.0pt">JEOL USA, Inc.,</span></b><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:13.0pt">Peabody MA 01960, U.S.A.</span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"><span style="font-size:13.0pt">Cell: +1 (978) 317-9561</span><o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"> <o:p></o:p></p>
</div>
<div>
<p class="MsoNormal">Sent from a mobile device. Please excuse typos and this email’s brevity.<o:p></o:p></p>
</div>
</div>
</div>
<div>
<p class="MsoNormal"><br>
<br>
<br>
<br>
<br>
<o:p></o:p></p>
<blockquote style="margin-top:5.0pt;margin-bottom:5.0pt">
<p class="MsoNormal" style="margin-bottom:12.0pt">On Jul 5, 2020, at 7:31 PM, Ruben Diaz
<a href="mailto:pindusito@gmail.com"><pindusito@gmail.com></a> wrote:<o:p></o:p></p>
</blockquote>
</div>
<blockquote style="margin-top:5.0pt;margin-bottom:5.0pt">
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<p class="MsoNormal">Hi Jian,<o:p></o:p></p>
</div>
<div>
<p class="MsoNormal"> <o:p></o:p></p>
</div>
<div>
<p class="MsoNormal">Yes, if we decide to put BSL2 specimens in the microscopes, we have to tell TFS about it, to make sure that their engineers are safe.<o:p></o:p></p>
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</div>
<div>
<p class="MsoNormal"> <o:p></o:p></p>
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<p class="MsoNormal">Ruben.<o:p></o:p></p>
</div>
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<p class="MsoNormal"> <o:p></o:p></p>
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<div>
<p class="MsoNormal">On Sun, Jul 5, 2020 at 5:28 PM jamon <<a href="mailto:jamonshi@gmail.com">jamonshi@gmail.com</a>> wrote:<o:p></o:p></p>
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<p>Dear Ruben,<o:p></o:p></p>
<p>Is it request by TFS (FEI)? <o:p></o:p></p>
<p>Regards,<o:p></o:p></p>
<p>Jian<o:p></o:p></p>
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<p class="MsoNormal">On 6/7/20 7:17 am, Ruben Diaz wrote:<o:p></o:p></p>
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<p class="MsoNormal">Hi all, <o:p></o:p></p>
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<p class="MsoNormal"> <o:p></o:p></p>
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<p class="MsoNormal">Due to the type of samples that we are interested in imaging, it would be advantageous for us to declare our facility as BSL2. This designation, however, has some implications in terms of the paperwork and safety measures that have to be
taken whenever service is called. Cost of course I am sure is another factor. Does anyone have experience as to the real implications that have to be considered? It is my understanding that once we declare the facility to be BSL2, every instrument is included
in the designation, and it is not reversible.<o:p></o:p></p>
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<p class="MsoNormal"> <o:p></o:p></p>
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<p class="MsoNormal">Any information will be greatly appreciated.<o:p></o:p></p>
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<p class="MsoNormal"> <o:p></o:p></p>
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<p class="MsoNormal">Ruben.<o:p></o:p></p>
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<p class="MsoNormal"> <o:p></o:p></p>
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<p class="MsoNormal">***************************<o:p></o:p></p>
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<p class="MsoNormal">Ruben Diaz Avalos,<o:p></o:p></p>
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<p class="MsoNormal">La Jolla Institute for Immunology,<o:p></o:p></p>
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Athena Cir, La Jolla, CA 92037</a>,<o:p></o:p></p>
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<p class="MsoNormal">La Jolla, CA 92037<o:p></o:p></p>
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<p class="MsoNormal">***************************<o:p></o:p></p>
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<p class="MsoNormal"> <o:p></o:p></p>
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<p class="MsoNormal"><br>
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