<div dir="ltr"><p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif"><span style="font-family:Arial,sans-serif">Dear Colleagues,</span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif"><span style="font-family:Arial,sans-serif"> </span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif"><span style="font-family:Arial,sans-serif">As scientists, we are
all trying to help, from our particular expertise, on ways to better
understand SARS-Covid-2 and the pandemic we are going through. In our case, we
work on image analysis and data management. Many of you know us well from
our software (XMIPP and Scipion), but all users of EMDB at EBI, whenever they
look at an entry, they also see the remark "3DBionote available for this
entry", and if you click on it you get into an interactive environment
where you can do your own "data mining" on structures and
annotations.</span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif"><span style="font-family:Arial,sans-serif"> </span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif"><span style="font-family:Arial,sans-serif">From this background,
we are happy to announce our new additional site "3DBionotes-Covid-19",
fully focused on the pandemic, that you can find at: </span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif"><span style="font-family:Arial,sans-serif"> </span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif"><a href="https://urldefense.com/v3/__http://3dbionotes.cnb.csic.es__;!!Mih3wA!TQ7phFRnvSnoBOdxC3WmqF7Va6TB53A8nnGr5djbkA0Yq8r5vV8K2rYL86kZZ0oA_A$" style="color:blue">http://3dbionotes.cnb.csic.es</a></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif"> </p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif">and then selecting the green option Covid-19<span style="font-family:Arial,sans-serif"></span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif"> </p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif"><span style="font-family:Arial,sans-serif">It starts "small" and far
from perfect, but it will grow as we get more data and we interoperate with
other resources. As always, this development is only possible because "we
stand on the shoulders of giants", and we acknowledge the great work of
Andrea Thorn's team at <span style="color:rgb(80,0,80)"><a href="https://urldefense.com/v3/__https://github.com/thorn-lab/coronavirus_structural_task_force__;!!Mih3wA!TQ7phFRnvSnoBOdxC3WmqF7Va6TB53A8nnGr5djbkA0Yq8r5vV8K2rYL86kTKu3SbA$" target="_blank" style="color:blue"><span style="color:rgb(17,85,204)">https://github.com/thorn-lab/coronavirus_structural_task_force</span></a></span>,
from where we take their refined structural models, so that within
3DBinotes-Covid19 you can always choose to work on the regular PDB model or,
instead, on PDB-redo or Isolde-analyzed models. And, of course, our colleagues
at EMDB, PDBe, Uniprot .... (and, in general, the work at EBI/ELIXIR) since
without them 3DBionotes would not be possible. Expect a closer integration with
PDB-KB Covid-19 efforts very soon (PDB in Europe Knowledge Base)</span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif"><span style="font-family:Arial,sans-serif;color:rgb(80,0,80)"> </span></p>

<p class="MsoNormal" style="margin:0in 0in 5pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif"><span style="font-family:Arial,sans-serif">In this first release we have worked hard to
offer you some genomics variants analysis, knowing that it is just a start and
that, surely, there will be many more sources of information in the near future
that will be subsequently incorporated. We also want to stress the crucial task of
compound screening, and we start in this first release with the three Fragment
Based Screening experiments performed at Diamond in the context of Instruct.UK;
of course, we need to grow a lot in this area. As a last remark, and since we
are coming from cryo EM, we are including cryo EM validation information, an
area in which we actively develop methods and that is particularly important
considering the pace of results coming from this field.</span></p><p class="MsoNormal" style="margin:0in 0in 5pt;line-height:normal;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial;font-family:Calibri,sans-serif"><span style="font-family:Arial,sans-serif"><br></span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;font-family:Calibri,sans-serif"><span style="font-family:Arial,sans-serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">Please, check by
yourself this very first implementation, which will be
substantially expanded in the coming weeks. We would love to know from you
about new initiatives we could interact with, since it is really time to
work together</span></p>

<p class="MsoNormal" style="margin:0in 0in 0.0001pt;line-height:normal;font-family:Calibri,sans-serif"><span style="font-family:Arial,sans-serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial"> </span></p>

<p class="MsoNormal" style="margin:0in 0in 8pt;line-height:107%;font-family:Calibri,sans-serif"><span style="line-height:107%;font-family:Arial,sans-serif;background-image:initial;background-position:initial;background-size:initial;background-repeat:initial;background-origin:initial;background-clip:initial">With
best wishes.... The 3DBionotes-Covid19 team</span></p><div><br></div>-- <br><div dir="ltr" class="gmail_signature" data-smartmail="gmail_signature"><div dir="ltr"><div><div dir="ltr"><div>Prof. Jose-Maria Carazo<br>Biocomputing Unit, Head</div><div>Instruct cryoEM Image Processing Center (I2PC), Director</div><div>INB/<a href="https://urldefense.com/v3/__http://ELIXIR.ES__;!!Mih3wA!TQ7phFRnvSnoBOdxC3WmqF7Va6TB53A8nnGr5djbkA0Yq8r5vV8K2rYL86kUro37VA$">ELIXIR.ES</a> CNB Node, Director</div><div>Spanish National Center for Biotechnology, CNB-CSIC</div><div>Darwin 3, Campus Universidad Autonoma de Madrid</div><div>28049 Madrid, Spain</div><div><p style="margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><br></p>Cell: +34639197980<br></div></div></div></div></div></div>