<!DOCTYPE html><html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8" /></head><body><div data-crea="font-wrapper" style="font-family: Tahoma; font-size: 16px; direction: ltr"><div><span lang="EN-US">Dear all,<br></span></div><div><span lang="EN-US"><br></span></div><div><span lang="EN-US">The Cryo-Electron Microscopy Service
Platform at EMBL Heidelberg provides mail-in access to its state-of-the-art
cryo-EM equipment for COVID-19-related projects (single-particle analysis and
cryo-electron tomography) using the latest technology and methods. The platform
hosts a FEI Titan Krios G3 equipped with a phase plate and a Quantum-K3 camera
and a 200 kV FEI Talos Arctica with an electron counting Falcon 3 camera. Both
microscopes are equipped with an automatic sample loading system and configured
for automatic data acquisition. <p></p></span></div>
<div><span lang="EN-US"><br></span></div><div><span lang="EN-US">Users can send in optimized frozen cryo-EM
grids for high-resolution data collection. Data collection will be carried out
by EMBL experts in close consultation with the users. In addition, we also
offer freezing and screening of grids for shipped-in purified samples depending
on capacity.<p></p></span></div>
<span lang="EN-US">If you want to benefit from free access to the
Cryo-Electron Microscopy Service Platform at EMBL Heidelberg for COVID-19-related
research, please send a project description to <a href="mailto:cryo-em@embl.de">cryo-em@embl.de</a>.
Projects will be evaluated with respect to scientific quality, feasibility and
biological safety. The project description should therefore include project
goals, description of the samples (i.e. cryo-EM images, class averages of
cryo-EM images, biophysical characterization) and biological safety of the
samples.<p></p></span><br><br><div>Yours,</div><div><br></div><div>Felix Weis<br></div><div>Cryo-electron microscopy service platform</div><div>EMBL Heidelberg<br></div><div><br></div><br><br><div></div><br></div></body></html>