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<div class="WordSection1">
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">All,<o:p></o:p></p>
<p class="MsoNormal">The Takeda Structural Biology & Biophysics group (San Diego, CA) has a new opening for a Scientist I, Structural Biology protein crystallography and cryo-EM (Job ID: R0012926). Candidates can apply using the link below.<o:p></o:p></p>
<p class="MsoNormal">Thanks in advance for your interest!<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Mack Flinspach<o:p></o:p></p>
<p class="MsoNormal">Associate Director<o:p></o:p></p>
<p class="MsoNormal">Structural Biology & Biophysics<o:p></o:p></p>
<p class="MsoNormal">9625 Towne Centre Dr.<o:p></o:p></p>
<p class="MsoNormal">San Diego CA 92121<o:p></o:p></p>
<p class="MsoNormal"><a href="mailto:Mack.flinspach@takeda.com">Mack.flinspach@takeda.com</a><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><a href="https://www.takedajobs.com/job/san-diego/scientist-i-structural-biology-protein-crystallography-and-cryoem/1113/13669472"><span style="color:#0563C1">https://www.takedajobs.com/job/san-diego/scientist-i-structural-biology-protein-crystallography-and-cryoem/1113/13669472</span></a><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><span style="color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><span style="color:black;border:none windowtext 1.0pt;padding:0in">Job Description</span></b><b><span style="color:black"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-bottom:12.0pt;background:white;vertical-align:baseline">
<span style="color:black">Are you looking for a patient-focused, innovation-driven company that will inspire you and empower you to shine? Join us as a Scientist I – Structural Biology protein crystallography and cryoEM at our recently dedicated San Diego
Research Site.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt;background:white;vertical-align:baseline">
<span style="color:black">At Takeda, we are transforming the pharmaceutical industry through our R&D-driven market leadership and being a values-led company. To do this, we empower our people to realize their potential through life-changing work. Certified
as a Global Top Employer, we offer stimulating careers, encourage innovation, and strive for excellence in everything we do. We foster an inclusive, collaborative workplace, in which our global teams are united by an unwavering commitment to deliver Better
Health and a Brighter Future to people around the world.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt;background:white;vertical-align:baseline">
<span style="color:black">Here, you will be a vital contributor to our inspiring, bold mission. As a Scientist I – Structural Biology protein crystallography and cryoEM, you will be empowered to serve on project teams for discovery to development programs.<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><i><span style="color:black;border:none windowtext 1.0pt;padding:0in">OBJECTIVES</span></i></b><span style="color:black"><o:p></o:p></span></p>
<ul type="disc">
<li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l6 level1 lfo1;background:white;vertical-align:baseline">
Seeking a highly motivated and collaborative Scientist I, Structural Biology, to provide expertise in 1) recombinant protein expression/purification, and 2) crystallographic/cryoEM structure determination of soluble and membrane proteins, protein-protein complexes
and protein-ligand complexes to support Takeda’s drug discovery programs. <o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l6 level1 lfo1;background:white;vertical-align:baseline">
This individual works collaboratively and effectively with other biologists, protein chemists, crystallographers and biophysicists in determining methodologies and strategies that best support Takeda’s internal and external drug discovery programs.<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l6 level1 lfo1;background:white;vertical-align:baseline">
Contributes to design, development and execution of research assignments, potentially contributing to multiple projects<o:p></o:p></li></ul>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><i><span style="color:black;border:none windowtext 1.0pt;padding:0in">ACCOUNTABILITIES</span></i></b><span style="color:black"><o:p></o:p></span></p>
<ul type="disc">
<li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l7 level1 lfo2;background:white;vertical-align:baseline">
Responsible for high-resolution cryoEM and crystallographic structure determination of proteins complexed with both large and small molecules and for supporting Structure-Based Drug Design (SBDD) and Fragment- Based Lead Discovery (FBLD)<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l7 level1 lfo2;background:white;vertical-align:baseline">
Strong aptitude for using structural data to help interpret data from other disciplines to generate testable SAR hypotheses and drive progress on portfolio programs<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l7 level1 lfo2;background:white;vertical-align:baseline">
Work collaboratively on pipeline projects with an interdisciplinary group of both internal and external project team members including disease-area biologists, medicinal chemistry, computational chemistry, in vitro/in vivo pharmacology, informatics, DMPK, DSRE,
and project management<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l7 level1 lfo2;background:white;vertical-align:baseline">
Responsible for optimizing expression and purification of proteins, including integral membrane proteins, from a variety of expression hosts<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l7 level1 lfo2;background:white;vertical-align:baseline">
Perform high-throughput crystal screening and optimization as well as cryoEM grid preparation across a number of platforms utilizing multiple methods, including automation.<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l7 level1 lfo2;background:white;vertical-align:baseline">
Utilize structural biology software packages including Coot, Phenix, Relion and CCP4 to provide high quality structural data for project teams. <o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l7 level1 lfo2;background:white;vertical-align:baseline">
Communicate structural data to various audiences, as well as interpretation and significance of the data, to help to drive the molecule design/testing iterations<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l7 level1 lfo2;background:white;vertical-align:baseline">
Maintain up-to-date understanding of the state of the field in cryoEM, x-ray crystallography structural biology as a whole and more broadly across drug discovery<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l7 level1 lfo2;background:white;vertical-align:baseline">
Initiate investigation of new experimental approaches to a wide range of problems using<br>
scientific theory and technical literature<o:p></o:p></li></ul>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><i><span style="color:black;border:none windowtext 1.0pt;padding:0in">DIMENSIONS AND ASPECTS</span></i></b><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><u><span style="color:black;border:none windowtext 1.0pt;padding:0in">Technical/Functional (Line) Expertise</span></u></b><span style="color:black"><o:p></o:p></span></p>
<ul type="disc">
<li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l2 level1 lfo3;background:white;vertical-align:baseline">
<span style="border:none windowtext 1.0pt;padding:0in">Demonstrated ability to rigorously and efficiently solve high quality structures of biological complexes of interest using cryoEM and x-ray crystallography</span><o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l2 level1 lfo3;background:white;vertical-align:baseline">
<span style="border:none windowtext 1.0pt;padding:0in">Experienced in all aspects of cryoEM and crystallographic workflows and in solving difficult structural biology challenges</span><o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l2 level1 lfo3;background:white;vertical-align:baseline">
<span style="border:none windowtext 1.0pt;padding:0in">Deep experience in membrane protein expression and purification</span><o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l2 level1 lfo3;background:white;vertical-align:baseline">
<span style="border:none windowtext 1.0pt;padding:0in">Expertise in structure determination software including Relion, CCP4, Phenix, and Coot. Experience with MOE and PyMol is highly desirable</span><o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l2 level1 lfo3;background:white;vertical-align:baseline">
<span style="border:none windowtext 1.0pt;padding:0in">Deep understanding of protein structure and function, with the ability to clearly communicate structural information and significance/interpretation to a broad audience</span><o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l2 level1 lfo3;background:white;vertical-align:baseline">
<span style="border:none windowtext 1.0pt;padding:0in">Rigorous, exacting, organized, creative and innovative approach to scientific inquiry.</span><o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l2 level1 lfo3;background:white;vertical-align:baseline">
Experience in various aspects of computational chemistry, including molecular docking and virtual screening, is a plus<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l2 level1 lfo3;background:white;vertical-align:baseline">
<span style="border:none windowtext 1.0pt;padding:0in">Enthusiasm for structural biology, drug discovery, and collaboration in an industrial setting </span><o:p></o:p></li></ul>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><u><span style="color:black;border:none windowtext 1.0pt;padding:0in">Leadership</span></u></b><span style="color:black"><o:p></o:p></span></p>
<ul type="disc">
<li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l1 level1 lfo4;background:white;vertical-align:baseline">
Identifies, plans and executes novel scientific projects and may manage the work of others a direct or matrixed structure<o:p></o:p></li></ul>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><u><span style="color:black;border:none windowtext 1.0pt;padding:0in">Decision-making and Autonomy</span></u></b><span style="color:black"><o:p></o:p></span></p>
<ul type="disc">
<li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l8 level1 lfo5;background:white;vertical-align:baseline">
Independently manages workload and expectations<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l8 level1 lfo5;background:white;vertical-align:baseline">
Scientifically independent<o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l8 level1 lfo5;background:white;vertical-align:baseline">
May influence decision making within the department<o:p></o:p></li></ul>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><u><span style="color:black;border:none windowtext 1.0pt;padding:0in">Interaction</span></u></b><span style="color:black"><o:p></o:p></span></p>
<ul type="disc">
<li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l4 level1 lfo6;background:white;vertical-align:baseline">
Conducts scientific presentations to internal audiences<o:p></o:p></li></ul>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><u><span style="color:black;border:none windowtext 1.0pt;padding:0in">Innovation</span></u></b><span style="color:black"><o:p></o:p></span></p>
<ul type="disc">
<li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l3 level1 lfo7;background:white;vertical-align:baseline">
Receives high level instructions on all work, determines methods on new assignments, works closely with manager, may manage junior staff<o:p></o:p></li></ul>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><i><span style="color:black;border:none windowtext 1.0pt;padding:0in">EDUCATION, BEHAVIORAL COMPETENCIES AND SKILLS:</span></i></b><span style="color:black"><o:p></o:p></span></p>
<ul type="disc">
<li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l0 level1 lfo8;background:white;vertical-align:baseline">
PhD degree in a scientific discipline<o:p></o:p></li></ul>
<ul type="disc">
<li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l5 level1 lfo9;background:white;vertical-align:baseline">
<b><span style="border:none windowtext 1.0pt;padding:0in">WHAT TAKEDA CAN OFFER YOU:</span></b><o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l5 level1 lfo9;background:white;vertical-align:baseline">
<span style="border:none windowtext 1.0pt;padding:0in">401(k) with company match and Annual Retirement Contribution Plan</span><o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l5 level1 lfo9;background:white;vertical-align:baseline">
<span style="border:none windowtext 1.0pt;padding:0in">Tuition reimbursement</span><o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l5 level1 lfo9;background:white;vertical-align:baseline">
<span style="border:none windowtext 1.0pt;padding:0in">Company match of charitable contributions</span><o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l5 level1 lfo9;background:white;vertical-align:baseline">
<span style="border:none windowtext 1.0pt;padding:0in">Health & Wellness programs including onsite flu shots and health screenings</span><o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l5 level1 lfo9;background:white;vertical-align:baseline">
<span style="border:none windowtext 1.0pt;padding:0in">Generous time off for vacation and the option to purchase additional vacation days</span><o:p></o:p></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;margin-left:0in;mso-list:l5 level1 lfo9;background:white;vertical-align:baseline">
<span style="border:none windowtext 1.0pt;padding:0in">Community Outreach Programs</span><o:p></o:p></li></ul>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><span style="color:black;border:none windowtext 1.0pt;padding:0in">Empowering Our People to Shine</span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><span style="color:black">Learn more at <a href="http://takedajobs.com/" target="_blank"><span style="color:black;border:none windowtext 1.0pt;padding:0in">takedajobs.com</span></a>.<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><span style="color:black;border:none windowtext 1.0pt;padding:0in">No Phone Calls or Recruiters Please.</span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><span style="color:black;border:none windowtext 1.0pt;padding:0in">#LI-KL</span><span style="color:black"><o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><span style="color:black;border:none windowtext 1.0pt;padding:0in">Locations</span></b><b><span style="color:black"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-bottom:12.0pt;background:white;vertical-align:baseline">
<span style="color:black">San Diego, CA<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><span style="color:black;border:none windowtext 1.0pt;padding:0in">Worker Type</span></b><b><span style="color:black"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-bottom:12.0pt;background:white;vertical-align:baseline">
<span style="color:black">Employee<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><span style="color:black;border:none windowtext 1.0pt;padding:0in">Worker Sub-Type</span></b><b><span style="color:black"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="margin-bottom:12.0pt;background:white;vertical-align:baseline">
<span style="color:black">Regular<o:p></o:p></span></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><b><span style="color:black;border:none windowtext 1.0pt;padding:0in">Time Type</span></b><b><span style="color:black"><o:p></o:p></span></b></p>
<p class="MsoNormal" style="background:white;vertical-align:baseline"><span style="color:black">Full time <br>
<br>
<b><span style="border:none windowtext 1.0pt;padding:0in">Job ID</span></b><span style="border:none windowtext 1.0pt;padding:0in"> R0012926</span><o:p></o:p></span></p>
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<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
</div>
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