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<p class="MsoNormal"><b><span style="font-size:11.0pt">S<sup>2</sup>C<sup>2</sup> Modeling Workshop – July 10-12, 2019<o:p></o:p></span></b></p>
<p><span style="font-size:11.0pt;font-family:"Calibri",sans-serif">Location: <span style="color:black;background:white">
SLAC National Accelerator Laboratory, Menlo Park, CA USA<o:p></o:p></span></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">Dear Colleagues<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-size:11.0pt;color:#222222">The missions of the Stanford-SLAC Cryo-EM Center (S<sup><span style="border:none windowtext 1.0pt;padding:0in">2</span></sup>C<sup><span style="border:none windowtext 1.0pt;padding:0in">2</span></sup>)
are:<o:p></o:p></span></p>
<p class="MsoNormal" style="vertical-align:baseline"><span style="font-size:11.0pt;color:#222222"><o:p> </o:p></span></p>
<p class="MsoListParagraphCxSpFirst" style="margin-bottom:11.25pt;mso-add-space:auto;text-indent:-.25in;mso-list:l0 level1 lfo2;vertical-align:baseline">
<![if !supportLists]><span style="font-size:11.0pt;color:#222222"><span style="mso-list:Ignore">1.<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:11.0pt;color:#222222">to provide access to state-of-the-art cryo-EM instruments for data collection towards atomic resolution structure determination of biochemically purified single particles.
<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpLast" style="margin-bottom:11.25pt;mso-add-space:auto;text-indent:-.25in;mso-list:l0 level1 lfo2;vertical-align:baseline">
<![if !supportLists]><span style="font-size:11.0pt;color:#222222"><span style="mso-list:Ignore">2.<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:11.0pt;color:#222222">to enable scientists across the nation to become independent cryo-EM investigators capable to carry out the entire workflow from specimen preparation to structure validation.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">We are pleased to announce that S<sup>2</sup>C<sup>2</sup> will host a three-day Cryo-EM Modeling workshop on July 10-12, 2019. This workshop, the third in a series, will cover
<span style="color:black;border:none windowtext 1.0pt;padding:0in">the basic principles and practical protocols to obtain atomic models based on cryo-EM density maps at near atomic resolution.<o:p></o:p></span></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;color:black;border:none windowtext 1.0pt;padding:0in"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt">The workshop will be conducted by experts in the field of map visualization, density segmentation and annotation, model building, model optimization, and ligand fitting. Special attention will be devoted to
validation tools that ensure model reliability and acceptability for deposition to map and model databases.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:11.0pt;color:black">The workshop agenda can be found at:
</span><a href="https://cryoem.slac.stanford.edu/s2c2/training/workshops"><span lang="EN-GB" style="font-size:11.0pt">https://cryoem.slac.stanford.edu/s2c2/training/workshops</span></a><span style="font-size:11.0pt;color:black">
</span><span lang="EN-GB" style="font-size:11.0pt;mso-fareast-language:EN-US"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:11.0pt;color:black">There is no registration fee for this workshop, but in-person attendance is limited to 40 participants. </span><a href="https://cryoem.slac.stanford.edu/s2c2/content/s%C2%B2c%C2%B2-event-application"><span lang="EN-GB" style="font-size:11.0pt">https://cryoem.slac.stanford.edu/s2c2/content/s%C2%B2c%C2%B2-event-application</span></a><span lang="EN-GB" style="font-size:11.0pt;color:black">
</span><span lang="EN-GB" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:11.0pt;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:11.0pt;color:black">We look forward to providing this training in July!</span><span lang="EN-GB" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-GB" style="font-size:11.0pt;color:black"> </span><span lang="EN-GB" style="font-size:11.0pt"><o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:5.0pt;margin-right:.5in;margin-bottom:5.0pt;margin-left:.5in;background:white">
<span lang="EN-GB" style="font-size:11.0pt;color:black">The Organizers (Wah Chiu,
</span><span style="font-size:11.0pt;color:black">Georgios</span><span lang="EN-GB" style="font-size:11.0pt;color:black"> Skiniotis, Britt Hedman, Michael Schmid)</span><span style="font-size:11.0pt;color:black"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;mso-fareast-language:EN-US"><o:p> </o:p></span></p>
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