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<div class=""><span class="" style="font-family: Georgia;">Dear All,</span></div>
<div class=""><span class="" style="font-family: Georgia;">We would like to bring to your attention a postdoctoral position available in the Department of Biology, MIT. We are seeking candidates with extensive experience in t</span><span class="" style="font-family: Georgia;">he
biochemistry and biophysics of integral membrane proteins. </span><span class="" style="font-family: Georgia;">As part of a drug discovery collaboration with Rectify Pharmaceuticals, this NIH STTR funded position provides a unique opportunity to engage in
the drug discovery process at the interface of academia and biotech. The research will be carried out in the laboratory of Professor Thomas Schwartz, MIT. The appointment is for one year, and is available immediately. </span><span class="" style="font-family: Georgia;">More
details are provided below. We are also attaching a pdf file for posting. We would greatly appreciate it if you could bring this to the attention of qualified candidates.</span></div>
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<p class="MsoNormal"><font class="" face="Georgia"> Best Regards,</font></p>
<div class=""><font class="" face="Georgia">Jonathan Moore, Ph. D.</font></div>
<div class=""><font class="" face="Georgia">Principal, Rectify Pharmaceuticals</font></div>
<div class=""><font class="" face="Georgia"><br class="">
</font></div>
<div class=""><font class="" face="Georgia">Thomas Schwartz, Ph. D.</font></div>
<div class=""><font class="" face="Georgia">Boris Magasanik Professor of Biology</font></div>
<div class=""><font class="" face="Georgia">MIT</font></div>
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<p class="MsoNormal"><b class=""><span class=""><font face="Georgia" class="">Postdoctoral Scientist - Membrane Protein Biochemistry and Biophysics in Drug Discovery</font></span></b></p>
<p class="MsoNormal"><span class="" style="font-family: Georgia;">The Department of Biology, MIT seeks a highly motivated candidate with state-of-the-art expertise in integral membrane protein biochemistry. The successful candidate will express, purify and
reconstitute proteins into liposomes and nanodiscs, develop functional assays, and carry out structural studies with </span><span class="" style="font-family: Georgia;">transporters implicated in rare disease. As part of a drug discovery collaboration with
Rectify Pharmaceuticals, the position provides a unique opportunity to engage in the drug discovery process at the interface of ac</span><span class="" style="font-family: Georgia; color: rgb(51, 51, 51);">ad</span><span class="" style="font-family: Georgia;">emia
and biotech. The research will be carried out in the laboratory of Professor Thomas Schwartz, </span><span class="" style="font-family: Georgia;">MIT. The appointment is for one year, and is available immediately. </span></p>
<div class=""><u class=""><font class="" face="Georgia">Key responsibilities:</font></u></div>
<div class=""><font class="" face="Georgia">- Design protein expression constructs and optimize yield and protein quality from insect and mammalian expression hosts</font></div>
<div class=""><font class="" face="Georgia">- Purify and reconstitute membrane proteins into lipid environments such as liposomes and nanodiscs for functional assay development</font></div>
<div class=""><font class="" face="Georgia">- Design small-scale activity assays for key disease mutants</font></div>
<div class=""><font class="" face="Georgia">- Characterize transporter structure and folding state using cryo-EM or other biophysical methods</font></div>
<div class=""><font face="Georgia" class=""><br class="">
</font></div>
<div class=""><font class="" face="Georgia"><u class="">Qualifications:</u></font></div>
<div class=""><span class=""><font face="Georgia" class=""><font class=""><span class="">- </span></font><span class="">Must have P</span><span class="">h.D. (or equivalent degree) in Protein Biochemistry, Structural Biology or a related field</span></font></span></div>
<div class=""><font class="" face="Georgia"><span class="">- Proven </span><span class="">expertise in membrane protein biochemistry as evidenced by a strong publication record and references</span></font></div>
<div class=""><span class=""><font face="Georgia" class=""><font class=""><span class="">- Experience </span><span class="">in mammalian protein expression, functional assay development or </span></font><font class="">cryo-EM a plus</font></font></span></div>
<div class=""><font class="" face="Georgia"><span class="">- </span><span class="">Excellent communic</span><span class="">ation skills (written and oral) and the ability to work in a close-knit, team environment is required</span></font></div>
<div class=""><font class="" face="Georgia"><br class="">
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<div class=""><font class="" face="Georgia">Interested candidates should send a cv with cover letter to Jonathan Moore at the address below:</font></div>
<div class=""><font class="" face="Georgia"><br class="">
</font></div>
<div class=""><font class="" face="Georgia">Dr. Jonathan Moore (Rectify Pharmaceuticals)</font></div>
<div class=""><font class="" face="Georgia"><span class=""><a href="mailto:moore@rectifypharma.com" class="">moore@rectifypharma.com</a></span></font></div>
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