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<p class="MsoNormal" style="margin-bottom:12.0pt"><span style="font-size:13.5pt;font-family:"Arial",sans-serif;color:black">Posting an event which should be generally interesting to the EM community. I am posting an announcement about a webinar, led by Structura
and Merck, to describe the use of cryo-EM for drug discovery. Please see the link below to register.<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><span style="font-size:13.5pt;font-family:"Arial",sans-serif;color:black"><a href="https://info.nvidia.com/cryoem-for-drug-discovery-reg-page">https://info.nvidia.com/cryoem-for-drug-discovery-reg-page</a><o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><span style="font-size:13.5pt;font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><span style="font-size:13.5pt;font-family:"Arial",sans-serif;color:black">Date: Wednesday, May 1, 2019<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><span style="font-size:13.5pt;font-family:"Arial",sans-serif;color:black">Time: 9:00am – 10:00am US Pacific time<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><span style="font-size:13.5pt;font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
<p class="MsoNormal" style="margin-bottom:12.0pt"><b><span style="font-size:14.0pt;font-family:"Arial",sans-serif;color:black">Description<o:p></o:p></span></b></p>
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<span style="font-size:13.5pt;font-family:"Arial",sans-serif;color:black">Cryo-electron microscopy (cryoEM) is a Nobel Prize-winning technique for solving high-resolution three-dimensional structures of biological molecules such as proteins, that is used for
structure-based drug design. Key to the success of cryoEM are significant advances in high performance computer vision and machine learning algorithms, used to extract information from large numbers of noisy 2D microscope images and compute and refine 3D structures
of target proteins in near-native states. <br>
<br>
This webinar will focus on highlighting these computational challenges, their solutions and implementations in the powerful cryoSPARC software suite, and the application of cryoEM within the structure-based drug design pipeline at Merck.<o:p></o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:13.5pt;font-family:"Arial",sans-serif;color:black;background:white">By attending this webinar, you'll learn:</span></b><span style="font-family:"Arial",sans-serif"><o:p></o:p></span></p>
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<span style="font-size:12.0pt;font-family:"Arial",sans-serif">How single-particle cryoEM works<o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:18.0pt;mso-list:l0 level1 lfo1;background:white">
<span style="font-size:12.0pt;font-family:"Arial",sans-serif">Key computational steps involved in cryoEM structure determination and state-of-the-art algorithms and solutions implemented in cryoSPARC<o:p></o:p></span></li><li class="MsoNormal" style="color:black;mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;line-height:18.0pt;mso-list:l0 level1 lfo1;background:white">
<span style="font-size:12.0pt;font-family:"Arial",sans-serif">Examples of cryoEM enabling new structural insights for drug discovery<o:p></o:p></span></li></ul>
<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
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<p class="MsoNormal"><span style="font-family:"Arial",sans-serif;color:black"><o:p> </o:p></span></p>
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