<html><head><meta http-equiv="Content-Type" content="text/html; charset=utf-8"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; line-break: after-white-space;" class=""><br class=""><div class="">
<div style="color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-stroke-width: 0px; word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;" class=""><div class=""><div class=""><br class="Apple-interchange-newline"><br class=""></div><div class=""><br class=""></div><div class="">Edward H. Egelman, Ph.D.</div><div class="">Harrison Distinguished Professor</div><div class="">Department of Biochemistry & Molecular Genetics</div><div class="">University of Virginia</div><div class="">phone: 434-924-8210</div><div class="">fax: 434-924-5069</div><div class=""><a href="mailto:egelman@virginia.edu" class="">egelman@virginia.edu</a></div><div class=""><p class="MsoNormal"><a href="http://www.people.virginia.edu/%7Eehe2n" class="">http://www.people.virginia.edu/~ehe2n</a><o:p class=""></o:p></p></div></div><div class=""><br class=""></div></div><br class="Apple-interchange-newline" style="color: rgb(0, 0, 0); font-family: Helvetica; font-size: 12px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-stroke-width: 0px;"><br class="Apple-interchange-newline">
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<div><br class=""><blockquote type="cite" class=""><div class="">Begin forwarded message:</div><br class="Apple-interchange-newline"><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">From: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">Sean Winkler <<a href="mailto:SWinkler@biophysics.org" class="">SWinkler@biophysics.org</a>><br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Subject: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class=""><b class="">[Press Release] Biophysical Society, Institutional and Industry Partners Host Dr. Eva Nogales for Congressional Briefing on the Cryo-EM Revolution</b><br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">Date: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">March 27, 2019 at 9:51:11 AM EDT<br class=""></span></div><div style="margin-top: 0px; margin-right: 0px; margin-bottom: 0px; margin-left: 0px;" class=""><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif; color:rgba(0, 0, 0, 1.0);" class=""><b class="">To: </b></span><span style="font-family: -webkit-system-font, Helvetica Neue, Helvetica, sans-serif;" class="">Undisclosed recipients:;<br class=""></span></div><br class=""><div class=""><div class="WordSection1" style="page: WordSection1; caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 14px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;"><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class="">Photos: _162200: Eva Nogales Briefing<o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class="">_1000 Rep. Barbara Lee and Eva Nogales<o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class="">_155257: Eric Sundberg and Ed Egelman (BPS – Public Affairs Committee) and Eva Nogales<o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif; text-align: right;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif; text-align: right;" class="">FOR IMMEDIATE RELEASE – March 27, 2019<o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif; text-align: right;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class="">Contact: Sean Winkler, Director, Public Affairs<o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class="">(847) 212-1493//<span class="Apple-converted-space"> </span><a href="mailto:swinkler@biophysics.org" style="color: rgb(149, 79, 114); text-decoration: underline;" class="">swinkler@biophysics.org</a><o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><a href="https://www.biophysics.org/news-room/bps-institutional-and-industry-partners-host-dr-eva-nogales-for-congressional-briefing-on-the-cryo-em-revolution" style="color: rgb(149, 79, 114); text-decoration: underline;" class="">Web Link</a><o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif; text-align: center;" class=""><b class=""><span style="font-size: 14pt;" class="">Biophysical Society, Institutional and Industry Partners Host Dr. Eva Nogales for Congressional Briefing on the<span class="Apple-converted-space"> </span><i class="">Cryo-EM Revolution</i></span></b><span style="font-size: 14pt;" class=""><o:p class=""></o:p></span></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><b class="">Washington, DC –<span class="Apple-converted-space"> </span></b>On March 26, the Biophysical Society (BPS), in coordination with Congresswoman Barbara Lee (D-CA-13), hosted Dr. Eva Nogales for a Congressional Briefing titled the Cryo-EM Revolution. The briefing was sponsored by the American Society for Cell Biology (ASCB), JEOL.USA, the Lawrence Berkeley National Laboratory (LBNL), and Thermo Fisher Scientific, in partnership with the University of California – Berkeley (UC-Berkeley).<o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class="">“We were pleased to host today’s informative briefing and are extremely grateful to our event sponsors and partners,” said Jennifer Pesanelli, Executive Officer, BPS. “Through sustained investments in basic science and technology development, the federal government continues to enable exciting scientific breakthroughs and possibilities. The story of Cryo-EM is the story of the successful partnership between researchers, academic and government institutions, and industry, which enables curiosity and job creation.”<span class="Apple-converted-space"> </span><o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class="">Cryo-Electron Microscopy (Cryo-EM) is a biophysical technique that can be used to determine the structure of biological molecules. It allows researchers to create accurate, detailed, 3-D models of intricate biological structures at the sub-cellular and molecular levels. The process is fairly described by its name:<span class="Apple-converted-space"> </span><o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt 0.5in; font-size: 11pt; font-family: Calibri, sans-serif; text-indent: -0.25in;" class=""><span style="font-family: Symbol;" class=""><span class="">·<span style="font-style: normal; font-variant-caps: normal; font-weight: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";" class=""> <span class="Apple-converted-space"> </span></span></span></span><i class="">‘Cryo’</i>: The process begins with a rapid cooling of a protein solution which contains the biomolecule researchers want to examine. When water is frozen normally, it forms crystalline ice. But extremely rapid cooling prevents water molecules from crystallizing, which helps to preserve the structure of the biomolecules.<o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt 0.5in; font-size: 11pt; font-family: Calibri, sans-serif; text-indent: -0.25in;" class=""><span style="font-family: Symbol;" class=""><span class="">·<span style="font-style: normal; font-variant-caps: normal; font-weight: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";" class=""> <span class="Apple-converted-space"> </span></span></span></span><i class="">‘Electron’</i>: The frozen protein solution is then imaged with a beam of electrons.<o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt 0.5in; font-size: 11pt; font-family: Calibri, sans-serif; text-indent: -0.25in;" class=""><span style="font-family: Symbol;" class=""><span class="">·<span style="font-style: normal; font-variant-caps: normal; font-weight: normal; font-stretch: normal; font-size: 7pt; line-height: normal; font-family: "Times New Roman";" class=""> <span class="Apple-converted-space"> </span></span></span></span><i class="">‘Microscopy’</i>: Microscopes magnify objects that cannot be seen with the naked eye. Just as a light microscope magnifies objects imaged with light, an electron microscope magnifies objects imaged with electrons. Using electrons instead of light, one can actually image atoms. <span class="Apple-converted-space"> </span><o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span class="A6" style="font-family: Calibri, sans-serif; color: rgb(34, 30, 31);">In 2017, the Nobel Prize in Chemistry<b class=""><span class="Apple-converted-space"> </span></b>was awarded to three scientists who played key roles in developing Cryo-EM.<span class="Apple-converted-space"> </span><o:p class=""></o:p></span></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span class="A6" style="font-family: Calibri, sans-serif; color: rgb(34, 30, 31);"><o:p class=""> </o:p></span></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class="">“Recent technical developments have made cryo-EM a high-resolution technique within the reach of many structural biologists,” said Dr. Eva Nogales. “Government support for access to expensive instruments and large computational resources, and further technological development, from sample preparation to image improvement and analysis, will allow our scientists to generate a full structural and functional description of the repertoire of molecular machines that make up our and other biological organisms cells. Such fundamental knowledge in turn will provide the background needed for the rational and systematic design of disease-fighting therapeutics and biological based solutions for energy and environmental sustainability.”<o:p class=""></o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span class="A6" style="font-family: Calibri, sans-serif; color: rgb(34, 30, 31);"><o:p class=""> </o:p></span></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span class="A6" style="font-family: Calibri, sans-serif; color: rgb(34, 30, 31);">Dr. Nogales’s briefing discussed the history of the technology, how it is used today, and shared some potential future policy recommendations to further its development.<span class="Apple-converted-space"> </span></span><span style="background-color: white;" class="">The federal government continues to support Cryo-EM technology through the National Institutes of Health's Common Fund and the Department of Energy's Office of Science.<o:p class=""></o:p></span></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class="">The event coincided with the annual<span class="Apple-converted-space"> </span><a href="https://www.biophysics.org/biophysics-week#/" style="color: rgb(149, 79, 114); text-decoration: underline;" class="">Biophysics Week</a>, a messaging week that calls attention to the field of biophysics.<o:p class=""></o:p></div><div style="border-style: none none double; border-bottom-width: 6.75pt; border-bottom-color: windowtext; padding: 0in 0in 1pt;" class=""><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif; border: none; padding: 0in;" class=""><o:p class=""> </o:p></div></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif; text-align: center;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 9pt 0.0001pt 0in; font-size: 11pt; font-family: Calibri, sans-serif; text-align: center;" class=""><i class=""><span style="font-size: 10pt;" class="">The Biophysical Society, founded in 1958, is a professional, scientific Society established to encourage development and dissemination of knowledge in biophysics. The Society promotes growth in this expanding field through its annual meeting, monthly journal, and committee and outreach activities. Its 9,000 members are located throughout the U.S. and the world, where they teach and conduct research in colleges, universities, laboratories and government agencies.</span></i><a href="http://www.biophysics.org/" style="color: rgb(149, 79, 114); text-decoration: underline;" class=""><i class=""><span style="font-size: 10pt;" class="">www.biophysics.org</span></i></a><i class=""><span style="font-size: 10pt;" class="">.</span></i><span style="font-size: 9pt;" class=""><o:p class=""></o:p></span></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><i class=""><span style="font-size: 9pt; background-color: yellow; background-position: initial initial; background-repeat: initial initial;" class=""><o:p class=""> </o:p></span></i></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><i class=""><span style="font-size: 9pt;" class=""><o:p class=""> </o:p></span></i></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" width="720" style="width: 5in; background-color: white; border-collapse: collapse; background-position: initial initial; background-repeat: initial initial;"><tbody class=""><tr class=""><td width="240" valign="top" style="width: 120pt; padding: 7.5pt 0in 9pt;" class=""><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif; line-height: 15.399999618530273px;" class=""><a href="https://www.biophysics.org/" target="_blank" style="color: rgb(149, 79, 114); text-decoration: underline;" class=""><span style="font-size: 10pt; line-height: 14px; font-family: Arial, sans-serif; color: rgb(51, 122, 183); text-decoration: none;" class=""><img border="0" id="Picture_x0020_1" alt="cid:image005.jpg@01D4DB1C.89863BF0" class="" apple-inline="yes" width="212" height="126" src="cid:image011.jpg@01D4E482.9AC28DF0"></span></a><span style="font-size: 10pt; line-height: 14px; font-family: Arial, sans-serif; color: rgb(68, 68, 68);" class=""><o:p class=""></o:p></span></div></td><td width="480" style="width: 240pt; padding: 4.5pt 0in;" class=""><table class="MsoNormalTable" border="0" cellspacing="0" cellpadding="0" style="border-collapse: collapse;"><tbody class=""><tr class=""><td style="padding: 0in;" class=""><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif; line-height: 15.399999618530273px;" class=""><b class=""><span style="font-size: 12pt; line-height: 16.799999237060547px; color: rgb(61, 60, 63);" class="">Sean Winkler</span></b><b class=""><span style="font-size: 12pt; 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line-height: 16.799999237060547px; font-family: "Times New Roman", serif;" class=""> </span><a href="https://www.instagram.com/biophysicalsociety/" target="_blank" style="color: rgb(149, 79, 114); text-decoration: underline;" class=""><span style="font-size: 12pt; line-height: 16.799999237060547px; font-family: "Times New Roman", serif; color: rgb(51, 122, 183); text-decoration: none;" class=""><img border="0" id="Picture_x0020_5" alt="cid:image004.png@01D4DB1C.89863BF0" class="" apple-inline="yes" width="35" height="35" src="cid:image015.png@01D4E482.9AC28DF0"></span></a><span style="font-size: 12pt; line-height: 16.799999237060547px; font-family: "Times New Roman", serif;" class=""><o:p class=""></o:p></span></div></td></tr></tbody></table></td></tr></tbody></table><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><b class=""><span style="" class="">SAVE THE DATE!</span></b><b class=""><span style="" class=""><o:p class=""></o:p></span></b></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="color: rgb(23, 147, 210);" class=""><a href="https://www.biophysics.org/2020meeting" style="color: rgb(149, 79, 114); text-decoration: underline;" class=""><span style="color: rgb(23, 147, 210);" class="">64th Annual Meeting</span></a><o:p class=""></o:p></span></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="" class="">February 15-19, 2020<o:p class=""></o:p></span></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><span style="" class="">San Diego, California<o:p class=""></o:p></span></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div><div style="margin: 0in 0in 0.0001pt; font-size: 11pt; font-family: Calibri, sans-serif;" class=""><o:p class=""> </o:p></div></div><img style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 14px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class="" apple-inline="yes" id="2EF18D40-E7A2-4674-AE34-656D836DD95A" src="cid:CBF362FB-360D-43A9-A2B1-B3B2DADD320F@lan"><img style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 14px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class="" apple-inline="yes" id="85A67811-B933-4FD8-96F2-20C0673A3E22" src="cid:6A35748B-CEE0-4409-947F-22A5C8D442E2@lan"><img style="caret-color: rgb(0, 0, 0); font-family: Helvetica; font-size: 14px; font-style: normal; font-variant-caps: normal; font-weight: normal; letter-spacing: normal; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; word-spacing: 0px; -webkit-text-stroke-width: 0px; text-decoration: none;" class="" apple-inline="yes" id="7127189E-0201-4649-8964-EEFAE8D41DD0" src="cid:D57346E5-C4F2-4F79-AD4C-741E864750DD@lan"></div></blockquote></div><br class=""></body></html>