<div dir="ltr">Dear Ali, Abbas and Joachim<div><br></div><div>I had already positively answered you, but I did not realize -as Chuck has done so well- that probably you were asking for a "testimonial now".</div><div><br></div><div>We, at Madrid, we would love to have access to your software. Not only it addresses a foundamente issue, but it does so in a very novel way.. Your published results are excellent, and we would be very glad not only to use it, but to integrate it in Scipion and allowing ourselves and our users to try it on a variate of problems. Indeed, people need to get the software to appreciate how everything really works, otherwise it s very difficult to imagine how to proceed further, </div><div><br></div><div>Wbw..JM and Carlos</div></div><br><div class="gmail_quote"><div dir="ltr" class="gmail_attr">On Thu, Feb 28, 2019 at 4:40 PM Sindelar, Charles <<a href="mailto:charles.sindelar@yale.edu">charles.sindelar@yale.edu</a>> wrote:<br></div><blockquote class="gmail_quote" style="margin:0px 0px 0px 0.8ex;border-left:1px solid rgb(204,204,204);padding-left:1ex">Dear Ali, Abbas, Joachim, I think I speak for all of us here at Yale saying we enthusiastically welcome your new software package. It is vital that your efforts (and cryo-EM methods development in general) receive strong funding support from the NIH and elsewhere, and I wholeheartedly back your efforts to be funded!!<br>
<br>
Yours, Chuck <br>
<br>
----------------------------------------------------------------------<br>
<br>
Date: Wed, 27 Feb 2019 20:13:09 +0000<br>
From: Ali Dashti <<a href="mailto:adashti@uwm.edu" target="_blank">adashti@uwm.edu</a>><br>
To: "<a href="mailto:3dem@ncmir.ucsd.edu" target="_blank">3dem@ncmir.ucsd.edu</a>" <<a href="mailto:3dem@ncmir.ucsd.edu" target="_blank">3dem@ncmir.ucsd.edu</a>><br>
Subject: [3dem] ManifoldEM software package<br>
Message-ID:<br>
<<a href="mailto:BN6PR16MB1858B4FE8A087DD6329E5485AD740@BN6PR16MB1858.namprd16.prod.outlook.com" target="_blank">BN6PR16MB1858B4FE8A087DD6329E5485AD740@BN6PR16MB1858.namprd16.prod.outlook.com</a>><br>
<br>
Content-Type: text/plain; charset="iso-8859-1"<br>
<br>
Dear 3DEM community members,<br>
<br>
<br>
We have developed a new open source software package for the community. ManifoldEM applies our manifold-based approach for mapping energy landscapes and analysis of functionally relevant continuous conformational changes from single-particle data (Dashti et al. PNAS 2014<<a href="https://nam05.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.pnas.org%2Fcontent%2F111%2F49%2F17492.short&data=02%7C01%7Ccharles.sindelar%40yale.edu%7C53f91ad860e646616e4208d69d765d01%7Cdd8cbebb21394df8b4114e3e87abeb5c%7C0%7C0%7C636869529041868419&sdata=YjiXP3zTxwtjDfqLyCEbEHMo3A8JByCZztPaN6iihmc%3D&reserved=0" rel="noreferrer" target="_blank">https://nam05.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.pnas.org%2Fcontent%2F111%2F49%2F17492.short&data=02%7C01%7Ccharles.sindelar%40yale.edu%7C53f91ad860e646616e4208d69d765d01%7Cdd8cbebb21394df8b4114e3e87abeb5c%7C0%7C0%7C636869529041868419&sdata=YjiXP3zTxwtjDfqLyCEbEHMo3A8JByCZztPaN6iihmc%3D&reserved=0</a>>, Dashti et al. BioRXiv 2019<<a href="https://nam05.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biorxiv.org%2Fcontent%2F10.1101%2F291922v2.abstract&data=02%7C01%7Ccharles.sindelar%40yale.edu%7C53f91ad860e646616e4208d69d765d01%7Cdd8cbebb21394df8b4114e3e87abeb5c%7C0%7C0%7C636869529041868419&sdata=ddi0uVewugbVtUqOk4q8BwFsObj43W4NMz1e%2FQ%2BRysA%3D&reserved=0" rel="noreferrer" target="_blank">https://nam05.safelinks.protection.outlook.com/?url=https%3A%2F%2Fwww.biorxiv.org%2Fcontent%2F10.1101%2F291922v2.abstract&data=02%7C01%7Ccharles.sindelar%40yale.edu%7C53f91ad860e646616e4208d69d765d01%7Cdd8cbebb21394df8b4114e3e87abeb5c%7C0%7C0%7C636869529041868419&sdata=ddi0uVewugbVtUqOk4q8BwFsObj43W4NMz1e%2FQ%2BRysA%3D&reserved=0</a>>). We wanted to r<br>
each out to you with the news and ask if such a software were publicly available, would you like to receive it, and be supported in its installation & use?<br>
<br>
<br>
We seek to secure grant funding for dissemination, workshop training, user support, software maintenance and further development. The statements of interest from the community are critical for the success of the application.<br>
<br>
<br>
Best Regards,<br>
<br>
<br>
Ali Dashti, Abbas Ourmazd and Joachim Frank<br>
<br>
<br>
<br>
_______________________________________________<br>
3dem mailing list<br>
<a href="mailto:3dem@ncmir.ucsd.edu" target="_blank">3dem@ncmir.ucsd.edu</a><br>
<a href="https://mail.ncmir.ucsd.edu/mailman/listinfo/3dem" rel="noreferrer" target="_blank">https://mail.ncmir.ucsd.edu/mailman/listinfo/3dem</a><br>
</blockquote></div><br clear="all"><div><br></div>-- <br><div dir="ltr" class="gmail_signature"><div dir="ltr"><div>Prof. Jose-Maria Carazo<br>Biocomputing Unit, Head, CNB-CSIC<br>Spanish National Center for Biotechnology</div><div>Darwin 3, Universidad Autonoma de Madrid</div><div>28049 Madrid, Spain</div><div><p style="margin:0cm 0cm 0.0001pt;font-size:12pt;font-family:"Times New Roman",serif"><br></p>Cell: +34639197980<br></div></div></div>