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<font face="Calibri,Arial,Helvetica,sans-serif">Dear 3DEM community members,</font></div>
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We have developed a new open source software package for the community.<span style="margin: 0px"> </span><span style="margin: 0px; background-color: white">ManifoldEM applies our manifold-based approach for mapping energy landscapes and analysis </span><span style="margin: 0px; border: 1pt none windowtext">of</span><span style="margin: 0px; background-color: white"> functionally
relevant continuous conformational changes from single-particle data </span><span style="margin: 0px; border: 1pt none windowtext">(<u><a href="https://www.pnas.org/content/111/49/17492.short" target="_blank" rel="noopener noreferrer" title="https://www.pnas.org/content/111/49/17492.short" style="margin: 0px">Dashti
et al. PNAS 2014</a>,<span style="margin: 0px"> </span><a href="https://www.biorxiv.org/content/10.1101/291922v2.abstract" target="_blank" rel="noopener noreferrer" title="https://www.biorxiv.org/content/10.1101/291922v2.abstract" style="margin: 0px">Dashti
et al. BioRXiv 2019</a></u></span><span style="margin: 0px; border: 1pt none windowtext">)</span><span style="margin: 0px; background-color: white">. We wanted to reach out to you with the news and ask if such a software were publicly available, w</span><span style="margin: 0px">ould
you like to receive it, and be supported in its installation & use?</span></p>
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<p style="margin: 0px"><span style="margin: 0px"><font color="black" face="Calibri,sans-serif"><span style="margin: 0px; font-size: 12pt">We seek to secure grant funding for dissemination, workshop training, user support, software<span> </span></span>maintenance<span style="margin: 0px; font-size: 12pt"> and
further development. The statements of interest from the community are critical for the success of the application.</span></font><br>
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<span style="margin: 0px">Best Regards,</span></p>
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<span style="margin: 0px">Ali Dashti, </span>Abbas Ourmazd and <span style="margin: 0px">Joachim Frank </span></p>
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