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<p class="MsoNormal"><b class=""><span class="" style="font-size: 14px;">Postdoctoral position in ion channel mechanism with cryo-EM available in the laboratory of Crina Nimigean at Weill Cornell Medical College in New York City</span></b></p>
<p class="MsoNormal"><span class="" style="font-size: 11pt;">There is an availability in the laboratory of Crina Nimigean for an enthusiastic postdoc who is interested in the molecular workings of ion channels. The successful candidate will investigate ion
channel structure and mechanism with single-particle cryo-EM and functional assays such as single-channel recordings, stopped-flow fluorescence, etc. The work in the lab is generally geared towards developing a mechanistic understanding of ion channels using
functional and structural techniques (see two recent articles below).</span></p>
<p class="MsoNormal"><span class="" style="font-size: 11pt;">We are located at the Weill Cornell Medical College on the upper east side of Manhattan, within the vibrant and international tri-Institutional scientific community, which is comprised of Rockefeller
University, Memorial Sloan Kettering and Weill Cornell. We have screening electron microscopes on site, within the newly established cryo-EM core facility at Cornell, and we have full access to state-of-the-art Titan Krios microscopes for high resolution data
collection at the New York Structural Biology Center and other cost-based facilities.</span></p>
<p class="MsoNormal"><i class=""><u class=""><span class="" style="font-size: 11pt;">Qualifications and experience:</span></u></i><span class="" style="font-size: 11pt;"> Candidates should hold a Ph.D. and have a solid background in biophysics, ion channel
electrophysiology, and/or protein biochemistry. Experience with cryo-EM is not required but welcome. Excellent verbal and written English communication skills, and ability to work in close collaboration with other researchers are required. <o:p class=""></o:p></span></p>
<p class="MsoNormal"><span class="" style="font-size: 11pt;">Qualified applicants should send a cover letter, CV, and the names of three references by email to Crina Nimigean at <a href="mailto:crn2002@med.cornell.edu" class=""><b class="">crn2002@med.cornell.edu</b></a>.<o:p class=""></o:p></span></p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 0.1in;"><i class=""><span class="" style="font-size: 10pt; font-family: "Times New Roman", serif;">Rheinberger J., Gao X., Schmidpeter P.A.M., Nimigean C.M. (2018) Ligand discrimination and gating in
CNG channels from apo and partial agonist-bound cryo-EM structures, <b class=""><u class="">eLife</u></b> doi: 10.7554/eLife.39775</span></i></p>
<p class="MsoListParagraphCxSpFirst" style="margin-left: 0.1in;"><i class=""><span class="" style="font-size: 10pt; font-family: "Times New Roman", serif;">Marchesi A., Gao X., Adaixo R.., Rheinberger J., Stahlberg H., Nimigean C.M., Scheuring S. (2018) An
iris diaphragm mechanism to gate a cyclic nucleotide-gated ion channel, <b class=""><u class="">Nature communications</u></b>, doi: 10.1038/s41467-018-06414-8</span></i></p>
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Crina Nimigean, Ph.D.</div>
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Weill Cornell Medical College</div>
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Associate Professor of Physiology and Biophysics in Anesthesiology</div>
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Associate Professor of Biochemistry</div>
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<a href="http://physiology.med.cornell.edu/faculty/nimigean/lab/" class="">http://physiology.med.cornell.edu/faculty/nimigean/lab/</a></div>
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Department of Anesthesiology, Box 124<br class="">
525 East 68th Street, Room A-1050<br class="">
New York, NY 10065</div>
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Phone: (212) 746 5947<br class="">
Fax: (212) 746 4879</div>
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