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<p class="MsoNormal" style="margin-bottom: 12pt; text-align: justify;"><font face="Helvetica" size="3">Dear All,</font></p>
<p class="MsoNormal" style="margin-bottom: 12pt; text-align: justify;"><font face="Helvetica" size="3">We are looking for postdoctoral fellows who are interested in ion channels and receptors.</font></p>
<p class="MsoNormal" style="margin-bottom: 12pt; text-align: justify;"><font face="Helvetica" size="3">Our research program focuses on understanding atomic-scale mechanisms of how membrane proteins function under normal and diseased states. Membrane proteins
play critical roles in nearly every aspect of physiological processes that encompass relaying signals between cells, transporting small molecules and ions across membrane and catalyzing vital enzymatic reactions. Importantly, membrane proteins constitute ~
60% of targets of currently approved drugs and thus in-depth knowledge about their inner workings is sorely needed to inform the development of effective therapeutic strategies for treating various human diseases.
<b><o:p></o:p></b></font></p>
<p class="MsoNormal" style="text-align: justify;"><font face="Helvetica" size="3">Our current research program focuses on structures, physiology, pathology, and pharmacology of receptors, transporters, and ion channels that play pivotal roles in the kidneys
and, when malfunction, cause various diseases in human. In one recent study, we determined structures of the PKD2 channel, which, when mutated, leads to development of polycystic kidney diseases (PKD) – a common genetic disorder that affects 12.5 million patients
worldwide. Moreover, we are also interested in developing pharmacological tools mainly for dissecting functions of ion channels and receptors, but also as drug leads for developing novel therapeutic strategies. To achieve these goals, we employ a multidisciplinary
approach that includes molecular biology, protein biochemistry, pharmacology, ion channel electrophysiological, and X-ray crystallography and single-particle electron cryo-microscopy (cryo-EM).<b><o:p></o:p></b></font></p>
<p class="MsoNormal" style="text-align: justify;"><font face="Helvetica" size="3"><b> </b></font></p>
<p class="MsoNormal" style="text-align: justify;"><font face="Helvetica" size="3">The University of Utah houses a state-of-the-art cryo-EM facility, including FEI Titan Krios and TF20 microscopes, both of which are equipped with a direct electron detector K2
camera. The University of Utah is committed to become a world-class center for elucidating fundamental biology by using cutting edge cryo-EM methodology.<b><o:p></o:p></b></font></p>
<p class="MsoNormal" style="text-align: justify;"><font face="Helvetica" size="3"><b> </b></font></p>
<p class="MsoNormal" style="text-align: justify;"><font face="Helvetica" size="3">Backgrounds in biochemistry, structural biology, or ion channel biophysics are preferred, but not required. Interested candidates are welcome to send his/her C.V. directly to
Erhu Cao (<a href="mailto:erhu.cao@biochem.utah.edu">erhu.cao@biochem.utah.edu</a>). More details about our research program is available at our website:
<a href="http://medicine.utah.edu/biochemistry/labs/cao-lab/">http://medicine.utah.edu/biochemistry/labs/cao-lab</a>/<b><o:p></o:p></b></font></p>
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</b></font></p>
<p class="MsoNormal" style="text-align: justify;"><font face="Helvetica" size="3">Very best,</font></p>
<p class="MsoNormal" style="text-align: justify;"><font face="Helvetica" size="3"><b><br>
</b></font></p>
<p class="MsoNormal" style="text-align: justify;"><font face="Helvetica" size="3">Erhu</font></p>
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<div>
<div><font class="Apple-style-span" color="#000000"><font class="Apple-style-span" face="Helvetica">Erhu Cao</font></font></div>
<div><font face="Helvetica">15 N Medical Drive, Rm 4100</font></div>
<div><font face="Helvetica">Department of Biochemistry</font></div>
<div><font face="Helvetica">School of Medicine at University of Utah</font></div>
<div><font face="Helvetica">Salt Lake City, UT 84112-5650</font></div>
<div><font face="Helvetica">Phone: 801-581-8899</font></div>
<div><font face="Helvetica">Email: <a href="mailto:Erhu.Cao@biochem.utah.edu">Erhu.Cao@biochem.utah.edu</a></font></div>
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<div><font face="Helvetica">Lab website: </font><font color="#0433ff"><a href="http://medicine.utah.edu/biochemistry/labs/cao-lab/" style="font-family: Helvetica; background-color: white;">http://medicine.utah.edu/biochemistry/labs/cao-lab</a>/</font></div>
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