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<span style="font-family: Calibri; font-size: large;" class="">Dear All, </span></div>
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<span style="font-family: Calibri; font-size: large;" class="">Here is a job posting o</span><span style="font-family: Arial;" class="">n behalf of</span><span style="font-family: Arial;" class=""> </span><b style="font-family: Arial;" class=""><span style="color: rgb(7, 29, 73);" class="">Abbvie
Bioresearch Center, </span></b><span style="font-family: Arial;" class="">Global Biologics – Protein Sciences </span></div>
<h4 class="primary_location" style="margin: 0px; padding: 0px; border: 0px; font-variant-ligatures: normal; font-variant-numeric: inherit; font-variant-east-asian: inherit; font-weight: inherit; font-stretch: inherit; line-height: 27px; font-family: 'Avenir LT W01 45 Book', Helvetica, Arial, Verdana, sans-serif; font-size: 17px; vertical-align: baseline; color: rgb(45, 41, 38); orphans: 2; widows: 2; background-color: rgb(255, 255, 255); border-top-left-radius: 0px !important; border-top-right-radius: 0px !important; border-bottom-right-radius: 0px !important; border-bottom-left-radius: 0px !important;">
<a href="https://abbvie.referrals.selectminds.com/jobs/4049/other-jobs-matching/location-only" style="margin: 0px; padding: 0px; border: 0px; font-style: inherit; font-variant-ligatures: inherit; font-variant-position: inherit; font-variant-caps: inherit; font-variant-numeric: inherit; font-variant-alternates: inherit; font-variant-east-asian: inherit; font-stretch: inherit; line-height: inherit; font-family: inherit; vertical-align: baseline; color: rgb(0, 130, 186); text-decoration: none; border-top-left-radius: 0px !important; border-top-right-radius: 0px !important; border-bottom-right-radius: 0px !important; border-bottom-left-radius: 0px !important;" class="">USA,
Massachusetts, Worcester</a></h4>
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<span style="font-size: 12pt;" class=""><a href="https://urldefense.proofpoint.com/v2/url?u=https-3A__abbvie.referrals.selectminds.com_jobs_senior-2Dscientist-2Dii-2Dprotein-2Dpurification-2D4049&d=DwMFAg&c=6vgNTiRn9_pqCD9hKx9JgXN1VapJQ8JVoF8oWH1AgfQ&r=favpEJAb1iNy50hxGWh68yD7hRr1EiS8eV6t1DT_lgE&m=7Nz6zBFkJqGcb3SWPwbr67fM9EJSHnS6XuoFpS4j1Oo&s=XPF1sPWiQ9pdxclL7UFF6l-9Z8h6zCyt8ykV-v5Lkws&e=" style="color: purple;" class="">https://abbvie.referrals.selectminds.com/jobs/senior-scientist-ii-protein-purification-4049</a><o:p class=""></o:p></span></div>
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<b class="">Job Description <o:p class=""></o:p></b></p>
<p class="m-8365309022912125717msoplaintext" style="margin-right: 0in; margin-left: 0in; font-family: 'Times New Roman', serif;">
The Global Protein Sciences (GPS) Group is seeking a highly motivated Senior Scientist to join its Protein Purification Group at AbbVie Bioresearch Center in Worcester, MA. As a member of the group, the candidate will be responsible for working in cross functional
teams with other scientists in various therapeutic areas as well as the Biologics generation group in Worcester to advance the pipeline. The successful candidate will have experience in protein engineering and purification of immunogens and therapeutics with
a good understanding of technologies for generating proprietary biotherapeutics.<o:p class=""></o:p></p>
<p class="m-8365309022912125717msoplaintext" style="margin-right: 0in; margin-left: 0in; font-family: 'Times New Roman', serif;">
<b class="">Key Responsibilities Include:<o:p class=""></o:p></b></p>
<p class="m-8365309022912125717msoplaintext" style="margin-right: 0in; margin-left: 0in; font-family: 'Times New Roman', serif;">
•Design alternate therapeutic formats (Multi-specifics, Non-Ig Scaffolds etc.), fusion proteins, immunogens from concept using computational tools (Rosetta/pymol/others) and execute through experimental production and characterization<o:p class=""></o:p></p>
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•Enable progression of targets through the pipeline with appropriate reagents that elucidate a mechanistic understanding of target biology<o:p class=""></o:p></p>
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•Design, express, purify and characterize soluble and membrane protein targets with enhanced expression and stability enabling functional studies and antibody discovery<o:p class=""></o:p></p>
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•Purify integral membrane proteins/complexes for querying target biology, therapeutic development and structural studies.<o:p class=""></o:p></p>
<p class="m-8365309022912125717msoplaintext" style="margin-right: 0in; margin-left: 0in; font-family: 'Times New Roman', serif;">
•Introduce and lead innovative science enabling publication and external presentations<o:p class=""></o:p></p>
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<b class="">Qualifications </b>•BS, MS or PhD with a strong foundation in biochemistry, protein purification, structural biology, and at least 12-14+ (BS), 10-12+ (MS) or 4-6+ (PhD) years of post-graduate experience in protein design and purification <o:p class=""></o:p></p>
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•Significant research experience as demonstrated by a track record of publications and scientific accomplishments<o:p class=""></o:p></p>
<p class="m-8365309022912125717msoplaintext" style="margin-right: 0in; margin-left: 0in; font-family: 'Times New Roman', serif;">
•Experience with commercially available automated purification systems<o:p class=""></o:p></p>
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•Experience with expression and purification from various host expression systems such as mammalian (HEK/CHO), insect/baculovirus and E.Coli.<o:p class=""></o:p></p>
<p class="m-8365309022912125717msoplaintext" style="margin-right: 0in; margin-left: 0in; font-family: 'Times New Roman', serif;">
•Experience in display technologies (phage, yeast) is a plus<o:p class=""></o:p></p>
<p class="m-8365309022912125717msoplaintext" style="margin-right: 0in; margin-left: 0in; font-family: 'Times New Roman', serif;">
•Demonstrated ability to work with multidisciplinary biologics groups in a fast paced discovery team setting<o:p class=""></o:p></p>
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•Participation in project teams and effective communication with team members throughout the organization.<o:p class=""></o:p></p>
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•Highly developed leadership skills and ability to engage collaborators across the organization<o:p class=""></o:p></p>
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<b class=""> Equal Opportunity Employer Minorities/Women/Veterans/Disabled<o:p class=""></o:p></b></p>
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<b class=""><span style="font-size: 10pt; text-transform: uppercase;" class="">MEDHA J. TOMLINSON, PH.D.</span></b><span style="font-size: 10pt; color: rgb(31, 73, 125);" class=""><o:p class=""></o:p></span></div>
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<span style="font-size: 10pt;" class="">Principal Research Scientist</span><span style="font-size: 10pt; color: rgb(31, 73, 125);" class=""><o:p class=""></o:p></span></div>
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<b class=""><span style="font-size: 10pt; color: rgb(7, 29, 73);" class="">Abbvie Bioresearch Center</span></b><span style="font-size: 10pt; color: rgb(31, 73, 125);" class=""><o:p class=""></o:p></span></div>
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<span style="font-size: 10pt;" class="">Global Biologics – Protein Sciences</span><span style="font-size: 10pt; color: rgb(31, 73, 125);" class=""><o:p class=""></o:p></span></div>
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<span style="font-size: 10pt;" class="">100 Research Drive</span><span style="font-size: 10pt; color: rgb(31, 73, 125);" class=""><o:p class=""></o:p></span></div>
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<span style="font-size: 10pt;" class="">Worcester, MA 01605</span><span style="font-size: 10pt; color: rgb(31, 73, 125);" class=""><o:p class=""></o:p></span></div>
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<div style="orphans: 2; widows: 2;" class=""><font class="Apple-style-span" face="Calibri" color="#797979" style="font-size: 12px;">------------------------------------------------------</font></div>
<div style="orphans: 2; widows: 2;" class=""><font class="Apple-style-span" face="Calibri" color="#797979" style="font-size: 12px;">Irina I. Serysheva, Ph.D.</font></div>
<div style="orphans: 2; widows: 2;" class=""><font face="Calibri" color="#797979" class=""><span style="font-size: 12px;" class="">Associate Professor, Department of Biochemistry and Molecular Biology</span></font></div>
<div style="orphans: 2; widows: 2;" class="">
<div style="margin: 0px;" class=""><font class="Apple-style-span" face="Calibri" color="#797979" style="font-size: 12px;">Director of Structural Biology Imaging Center</font></div>
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<div style="orphans: 2; widows: 2; margin: 0px;" class="">
<div style="margin: 0px;" class=""><font class="Apple-style-span" face="Calibri" color="#797979" style="font-size: 12px;">McGovern Medical School </font></div>
<div style="margin: 0px;" class=""><font class="Apple-style-span" face="Calibri" color="#797979" style="font-size: 12px;">The University of Texas Health Science Center at Houston</font></div>
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<div style="orphans: 2; widows: 2; margin: 0px;" class=""><font class="Apple-style-span" face="Calibri" color="#797979" style="font-size: 12px;">6431 Fannin, MSB 6.210, Houston, TX 77030 </font></div>
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<font class="Apple-style-span" face="Calibri" color="#797979" style="font-size: 12px;"><br class="">
</font></div>
<div style="orphans: 2; widows: 2; margin: 0px;" class=""><font class="Apple-style-span" face="Calibri" color="#797979" style="font-size: 12px;">Tel.: 713-500-5523 (office); 713-500-6232 (lab)</font></div>
<div style="orphans: 2; widows: 2; margin: 0px;" class=""><font class="Apple-style-span" face="Calibri" color="#797979" style="font-size: 12px;">Fax: 713-500-0652</font></div>
<div style="orphans: 2; widows: 2; margin: 0px;" class=""><font class="Apple-style-span" face="Calibri" color="#797979" style="font-size: 12px;">E-mail: <a href="mailto:Irina.I.Serysheva@uth.tmc.edu" class="">Irina.I.Serysheva@uth.tmc.edu</a></font></div>
<div style="orphans: 2; widows: 2; margin: 0px;" class=""><font class="Apple-style-span" face="Calibri" color="#797979" style="font-size: 12px;"> <a href="mailto:irinas@bcm.edu" class="">irinas@bcm.edu</a></font></div>
<div style="orphans: 2; widows: 2; margin: 0px;" class=""><font class="Apple-style-span" face="Calibri" color="#797979" style="font-size: 12px;">https:/<a href="http://med.uth.edu/bmb/faculty/serysheva-irina/" class="">med.uth.edu/bmb/faculty/serysheva-irina/</a></font></div>
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<div class=""><span style="orphans: 2; widows: 2; font-size: 12px;" class=""><font face="Calibri" color="#797979" class="">"Success is the ability to go from one failure to another with no loss of enthusiasm" - Sir Winston Churchill</font></span></div>
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