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<p class="4MainContent"><span lang="EN-GB">Dear All,</span></p>
<p class="4MainContent"><span lang="EN-GB"> </span></p>
<p class="4MainContent"><span lang="EN-GB">Anyone interested in a Postdoctoral opportunity combining electron microscopy and Mass spectrometry to investigate the role of lipid composition on membrane protein structure and stability? then read on.</span></p>
<p class="4MainContent"><span lang="EN-GB"><span style="mso-spacerun:yes"> <br>
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<p class="4MainContent"><span lang="EN-GB"><span style="mso-spacerun:yes"></span>This is an opportunity to be part of a 3 year project funded by BBSRC, GlaxoSmithkline, and UCB to study the importance of specific lipids in membrane protein structure and function.
To address this important question this project will combine cutting edge mass spectrometry and EM, taking advantage of the recent investment within the University of Leeds. This includes the Astbury Biostructure facility which houses two Titan Krios microscopes
and a ~£1M investment in the mass spectrometry facility to incorporate an ion-mobility enabled Q-TOF mass spectrometer, a fully automated HDX-MS system, FPOP (Fast Photochemical Oxidation of Proteins) and a custom-modified Orbitrap.
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<p class="4MainContent"><span lang="EN-GB"> </span></p>
<p class="4MainContent"><span lang="EN-GB">This project is built upon our previous work looking at new methodologies for membrane protein extraction, in particular styrene maleic acid co-polymers (SMA) (Lee
<i>et al</i>., Nat Protocols 2016 & Parmar <i>et al</i>., BBA Biomembranes 2017).<span style="mso-spacerun:yes">
</span>For an overview of recent research by the group see Agip AA <i style="mso-bidi-font-style:normal">
et al</i>., Nat. Struct. Mol. Biol. 2018, Rawson S <i style="mso-bidi-font-style:normal">
et al</i>., PNAS 2018 & Amporndanai K <i style="mso-bidi-font-style:normal">et al</i>., IUCrJ 2018.
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<p class="4MainContent"><span lang="EN-GB">For more information and to apply, please visit;</span></p>
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"Times New Roman";mso-hansi-font-family:Calibri;mso-bidi-font-family:Arial;
color:black"><a href="https://jobs.leeds.ac.uk/Vacancy.aspx?id=12102&forced=2" target="_blank" id="LPlnk825829" class="OWAAutoLink" previewremoved="true"><span style="font-size:11.0pt;color:blue">https://jobs.leeds.ac.uk/Vacancy.aspx?id=12102&forced=2</span></a></span><span style="font-family:"Times New Roman";mso-fareast-font-family:"Times New Roman""></span></p>
<p class="4MainContent"><span lang="EN-GB"> </span></p>
<p class="4MainContent"><span lang="EN-GB">Any questions please contact Dr Stephen Muench (s.p.muench@leeds.ac.uk)</span></p>
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<p style="margin-top:0;margin-bottom:0">Best wishes,</p>
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<p style="margin-top:0;margin-bottom:0">Ste<br>
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<div class="PlainText">Dr Stephen Muench<br>
School of Biomedical Sciences<br>
University of Leeds<br>
Leeds<br>
LS2 9JT<br>
+44(0) 113 3434279</div>
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