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<p class="MsoNormal"><b><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Two post-doctoral positions in the Netherlands Cancer Institute<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Two post-doctoral positions are available in the Netherlands Cancer Institute in the group of Titia Sixma. We study mechanisms of enzyme regulation in DNA repair, using a
combination of stuctural biology, biochemistry, biophysics and cellular assays. We are particularly focussed on processes of ubiquitin conjugation and DNA mismatch repair.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">The institute is well set up for protein expression and characterisation (sharing equipment with the Protein Facility, an Instruct-ERIC and iNEXT participant), has an excellent
computing infrastructure (hosting the NKI Research High Performance Computing Unit) and also regular, well-established access to testing and high resolution facilities for NMR, cryo-EM and synchrotrons. The labs and work discussions are shared with the groups
of Tassos Perrakis and Robbie Joosten, who are interested in method development for structural biology (including the PDB-REDO project) as well as the group of Thijn Brummelkamp who is interested in developing and applying novel genetics approaches. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">The Netherlands Cancer Institute is a center of excellence with a high standard of biological research and an interactive atmosphere, with shared group meetings and social
events. Amsterdam is a liveable city, with its many cultural amenities within easy reach and within easy access to most European cities, through the closeby Schiphol airport (<30 minutes).<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Currently we have vacancies for:</span><span class="apple-converted-space"><span style="font-size:11.0pt"> <o:p></o:p></span></span></p>
<p class="MsoListParagraph" style="margin-left:54.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1">
<![if !supportLists]><span style="font-size:11.0pt"><span style="mso-list:Ignore">1)<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">An experienced crystallographer for a project focussing on crystallization of allosteric enzymes.<o:p></o:p></span></p>
<p class="MsoListParagraph" style="margin-left:54.0pt;text-indent:-18.0pt;mso-list:l0 level1 lfo1">
<![if !supportLists]><span style="font-size:11.0pt"><span style="mso-list:Ignore">2)<span style="font:7.0pt "Times New Roman"">
</span></span></span><![endif]><span class="apple-converted-space"><span style="font-size:7.0pt"> </span></span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">A researcher with experience in cryo-EM for a project in DNA replication.</span><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Appointments are for 3 years. Applicants should write an e-mail with motivation, CV and names of three references to <a href="mailto:t.sixma@nki.nl"><span style="color:purple">t.sixma@nki.nl</span></a>
before May 19<sup>th</sup>.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Titia Sixma<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Division of Biochemistry<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Netherlands Cancer Institute<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">Plesmanlaan 121<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif"">1066 CX Amsterdam<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:11.0pt;font-family:"Calibri","sans-serif""> <o:p></o:p></span></p>
<p class="MsoPlainText"><o:p> </o:p></p>
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