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<p>Critical Assessment of Techniques for Protein Structure
Prediction (<a href="http://www.predictioncenter.org"
target="_blank">CASP</a>) community experiments aim to advance
the state of the art in protein structure modeling. Every other
year since 1994, CASP collects information on soon-to-be released
experimental structures, passes on sequence data to the structure
modeling community, and collects blind predictions of structure
for assessment. About 100 modeling groups from around the world
participate. Results of CASP experiments are published in special
issues of the journal PROTEINS (e.g., CASP12: <a
href="https://onlinelibrary.wiley.com/toc/10970134/86/S1"
target="_blank">Proteins Vol 86, Issue S1, March 2018</a>).</p>
<p>The thirteenth CASP round is scheduled to start on May 1, 2018. <i>The
organizing committee is particularly keen to include many
cryo-EM-derived structure targets in this round.</i></p>
<p>The success of CASP depends on the generosity of the structure
determination community. Modeling targets are needed over a wide
range of difficulty, for modeling both with and without the aid of
templates. Targets that can be modeled based on structural
templates should ideally have 50% or less sequence identity to the
templates. Access to the structure in advance of its release by
the PDB or its publication is not needed. With sufficient
notification to CASP (a minimum of three weeks before release,
more is better) there is no need to delay structure release. If
you have recently determined a novel protein structure and will be
depositing it to PDB, please suggest it as a target for CASP by
visiting <a target="_blank"
href="http://www.predictioncenter.org/casp13/targets_submission.cgi">www.predictioncenter.org/casp13/targets_submission.cgi</a>.
If you have any questions please contact <a
href="mailto:casp@predictioncenter.org">casp@predictioncenter.org</a>.</p>
<p>CASP target providers are regularly invited to contribute to
special issue papers, for example:</p>
<ul>
<li>2018: Kryshtafovych A, Albrecht R, Baslé A, Bule P, Caputo AT,
Carvalho AL, Chao KL, Diskin R, Fidelis K, Fontes CMGA,
Fredslund F, Gilbert HJ, Goulding CW, Hartmann MD, Hayes CS,
Herzberg O, Hill JC, Joachimiak A, Kohring GW, Koning RI, Lo
Leggio L, Mangiagalli M, Michalska K, Moult J, Najmudin S,
Nardini M, Nardone V, Ndeh D, Nguyen TH, Pintacuda G, Postel S,
van Raaij MJ, Roversi P, Shimon A, Singh AK, Sundberg EJ, Tars
K, Zitzmann N, Schwede T. (2018). Target highlights from the
first post-PSI CASP experiment (CASP12, May-August 2016).
Proteins 86 (S1), 27-50. doi: <a
href="http://dx.doi.org/10.1002/prot.25392" target="_blank">10.1002/prot.25392</a>.
PMID: 2896053</li>
<li>2016:
Kryshtafovych A, Moult J, Baslé A, Burgin A, Craig TK,
Edwards RA, Fass D, Hartmann MD, Korycinski M, Lewis RJ, Lorimer
D, Lupas AN, Newman J, Peat TS, Piepenbrink KH, Prahlad J, van
Raaij MJ, Rohwer F, Segall AM, Seguritan V, Sundberg EJ, Singh
AK, Wilson MA, Schwede T. (2016). Some of the most interesting
CASP11 targets through the eyes of their authors. Proteins 84
(S1), 34-50. doi: <a
href="http://dx.doi.org/10.1002/prot.24942" target="_blank">10.1002/prot.24942</a>.
PMID: 26473983 </li>
<li>2014: Kryshtafovych A, Moult J, Bales P, Bazan JF, Biasini M,
Burgin A, Chen C, Cochran FV, Craig TK, Das R, Fass D,
Garcia-Doval C, Herzberg O, Lorimer D, Luecke H, Ma X, Nelson
DC, van Raaij MJ, Rohwer F, Segall A, Seguritan V, Zeth K,
Schwede T. (2014). Challenging the state-of-the-art in protein
structure prediction: Highlights of experimental target
structures for the 10th critical assessment of techniques for
protein structure prediction experiment CASP10. Proteins 82
(S2), 26-42. doi: <a
href="http://dx.doi.org/10.1002/prot.24489" target="_blank">10.1002/prot.24489</a>.
PMID: 2431898</li>
<li>2011: Kryshtafovych A, Moult J, Bartual SG, Bazan JF, Berman
H, Casteel DE, Christodoulou E, Everett JK, Hausmann J,
Heidebrecht T, Hills T, Hui R, Hunt JF, Seetharaman J,
Joachimiak A, Kennedy MA, Kim C, Lingel A, Michalska K,
Montelione GT, Otero JM, Perrakis A, Pizarro JC, van Raaij MJ,
Ramelot TA, Rousseau F, Tong L, Wernimont AK, Young J, Schwede
T. (2011). Target highlights in CASP9: Experimental target
structures for the critical assessment of techniques for protein
structure prediction. Proteins 79 (S10), 6-20. doi: <a
href="http://dx.doi.org/10.1002/prot.23196" target="_blank">10.1002/prot.23196</a>.
PMID: 2202078</li>
</ul>
<p>Posted on behalf of the CASP organizing committee:<br>
John Moult, University of Maryland, USA<br>
Krzysztof Fidelis, University of California, Davis, USA <br>
Andriy Kryshtafovych, University of California, Davis USA<br>
Torsten Schwede, University of Basel, Switzerland</p>
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