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<p style="margin-top:0; margin-bottom:0">dear all,</p>
<br>
<p style="margin-top:0; margin-bottom:0"><span style="color:rgb(0,111,201)">Application closing date is Monday 26 Feb.</span><br>
</p>
<br>
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<p style="margin-top:0; margin-bottom:0">A new postdoctoral position is available at the
<b>Francis Crick Institute</b> in London. </p>
<p style="margin-top:0; margin-bottom:0"><br>
</p>
<p style="margin-top:0; margin-bottom:0">Our group (Est. 2012) works on the mechanism of eukaryotic chromosome replication. </p>
<p style="margin-top:0; margin-bottom:0"><span style="font-family:Calibri,Arial,Helvetica,sans-serif,Helvetica,EmojiFont,"Apple Color Emoji","Segoe UI Emoji",NotoColorEmoji,"Segoe UI Symbol","Android Emoji",EmojiSymbols; font-size:12pt"><br>
</span></p>
<p style="margin-top:0; margin-bottom:0"><span style="font-family:Calibri,Arial,Helvetica,sans-serif,Helvetica,EmojiFont,"Apple Color Emoji","Segoe UI Emoji",NotoColorEmoji,"Segoe UI Symbol","Android Emoji",EmojiSymbols; font-size:12pt">We are looking for an
enthusiastic researcher interested in how molecular machines function.</span></p>
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<div><br>
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<div>The perfect candidate will have a background in Biochemistry and/or Structural Biology. Prior experience in cryo-EM would be an advantage and not a strict requirement.</div>
<div><br>
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<p style="font-family:Calibri,Helvetica,sans-serif,Helvetica,EmojiFont,"Apple Color Emoji","Segoe UI Emoji",NotoColorEmoji,"Segoe UI Symbol","Android Emoji",EmojiSymbols">
Available resources at the Crick include: </p>
<p style="font-family:Calibri,Helvetica,sans-serif,Helvetica,EmojiFont,"Apple Color Emoji","Segoe UI Emoji",NotoColorEmoji,"Segoe UI Symbol","Android Emoji",EmojiSymbols">
<br>
</p>
<p style="font-family:Calibri,Helvetica,sans-serif,Helvetica,EmojiFont,"Apple Color Emoji","Segoe UI Emoji",NotoColorEmoji,"Segoe UI Symbol","Android Emoji",EmojiSymbols">
</p>
<ol style="font-family:Calibri,Helvetica,sans-serif,Helvetica,EmojiFont,"Apple Color Emoji","Segoe UI Emoji",NotoColorEmoji,"Segoe UI Symbol","Android Emoji",EmojiSymbols; margin-bottom:0px; margin-top:0px">
<li>access to cryo-EM instruments: <b>2 Krios</b>,<b> </b><b>1 Talos</b> <b>Arctica</b> microscopes, all equipped with direct detectors; <b>2 Spirit </b>microscopes for cryo-EM grid screening.</li><li>access to state-of-the-art Science Technology Platforms, including Fermentation, Mass Spectrometry, Peptide Synthesis, Structural Biology and Scientific Computing.</li><li>A fully equipped Biochemistry lab with generous core funding from the Crick.</li></ol>
</div>
<div><br>
</div>
<div>Interested individuals are welcome to contact me directly for more information.</div>
<div><br>
</div>
<div>Best,</div>
<div>Alessandro </div>
<div><b><br>
</b></div>
<div><b>Here are a few links:</b></div>
<div><br>
</div>
<div>The job:</div>
<div><br>
</div>
<div><u style="color:rgb(33,33,33); font-family:Calibri,sans-serif; font-size:14.666666984558105px"><span style="font-size:10pt; font-family:"Trebuchet MS",sans-serif,serif,EmojiFont; color:blue" lang="EN-GB"><a href="https://jobs.crick.ac.uk/pls/corehrrecruit/erq_jobspec_version_4.display_form?p_company=1&p_internal_external=E&p_display_in_irish=N&p_applicant_no=&p_recruitment_id=007004&p_process_type=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y" target="_blank" rel="noopener noreferrer" id="LPlnk146374" previewremoved="true">https://jobs.crick.ac.uk/pls/corehrrecruit//erq_jobspec_version_4.display_form?p_company=1&p_internal_external=E&p_display_in_irish=N&p_applicant_no=&p_recruitment_id=007004&p_process_type=&p_form_profile_detail=&p_display_apply_ind=Y&p_refresh_search=Y</a></span></u><br>
</div>
<div><br>
</div>
<div><br>
</div>
<div>The lab:</div>
<div><br>
</div>
<div><a href="https://www.crick.ac.uk/research/a-z-researchers/researchers-a-c/alessandro-costa/" class="x_x_OWAAutoLink" id="LPlnk272504" previewremoved="true">https://www.crick.ac.uk/research/a-z-researchers/researchers-a-c/alessandro-costa/</a><br>
<br>
</div>
<div><br>
</div>
<div>The Crick:</div>
<div><br>
</div>
<div><a href="https://www.crick.ac.uk" class="x_x_OWAAutoLink" id="LPlnk727972" previewremoved="true">https://www.crick.ac.uk</a><br>
<br>
</div>
<div><br>
</div>
<div><b>Selected papers:</b></div>
<div><br>
</div>
<div><span style="font-size:11pt"></span><span style="font-size:11pt"></span><span style="font-size:11pt"></span><span style="font-size:11pt"></span><span style="font-size:11pt"></span><span style="font-size:11pt"></span><span style="font-size:11pt"></span><span style="font-size:11pt"></span><span style="font-size:11pt"></span><span style="font-size:11pt"></span><span style="font-size:11pt"></span><span style="font-size:11pt"></span><span style="font-size:11pt"></span>
<p style="margin-top:0cm; margin-right:0cm; margin-bottom:3.0pt; margin-left:0cm">
<span style="font-size:11pt; line-height:115%; font-family:Calibri,Helvetica,sans-serif; color:rgb(0,0,0)">Abid Ali F</span><span style="font-size:11.0pt; line-height:115%; font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">,
Douglas ME, </span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Locke J</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">, Pye VE, Nans A, Diffley JF,
</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Costa A</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">
</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"><i>CRYO-EM STRUCTURE OF A LICENSED DNA REPLICATION ORIGIN.
</i></span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"><b>Nat Commun., </b></span></span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:14.666666984558105px">2017 Dec;</span><span style="font-size:11pt; line-height:115%; font-family:Arial"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt"> </span></span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt">8</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt">,
2241</span></p>
<span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"></span>
<p class="x_x_MsoNormal" style="margin-bottom:3.0pt"><span style="font-size:11.0pt; line-height:115%; font-family:Arial" lang="EN-US"><span style="font-size:11pt; line-height:16.866666793823242px" lang="EN-US"><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif">Abid
Ali F</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif">^</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif">,</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif"> </span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif">Renault
L</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif">^</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif">,</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif"> </span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif">Gannon
J</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif">, Gahlon HL, Kotecha A,</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif"> </span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif">Zhou
JC</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif">, Rueda D,</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif"> </span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif">Costa A.</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif"> </span><i><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt">CRYO-EM
STRUCTURES OF THE EUKARYOTIC REPLICATIVE HELICASE BOUND TO A TRANSLOCATION SUBSTRATE.</span></i><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif"> <b>Nat. commun.</b>, 2016 Feb 18;7:10708 (^equal contribution).</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"><br>
</span></span></span></p>
<p class="x_x_MsoNormal" style="margin-bottom:3.0pt"><span style="font-size:11.0pt; line-height:115%; font-family:Arial" lang="EN-US"><span style="font-size:11pt; line-height:16.866666793823242px" lang="EN-US"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Ballandras-Colas
A, Maskell DP, Serrao E, </span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Locke J</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">,</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Swuec
P</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">, Jónsson SR, Kotecha A, Cook NJ, Pye VE, Taylor IA, Andrésdóttir V, Engelman AN,</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Costa
A</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">*, Cherepanov P*.</span></span><span style="font-size:11pt; line-height:16.866666793823242px" lang="EN-US"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span><i><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">A
SUPRAMOLECULAR ASSEMBLY MEDIATES LENTIVIRAL DNA INTEGRATION.</span></i><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"><b>Science</b>.</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">2017
Jan 6;355(6320):93-95. </span></span></span></p>
<p class="x_x_MsoNormal" style="margin-bottom:3.0pt"><span style="font-size:11.0pt; line-height:115%; font-family:Arial" lang="EN-US"><span style="font-size:11pt; line-height:16.866666793823242px" lang="EN-US"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Maskell
DP, </span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Renault L</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">, Serrao E, Lesbats P, Matadeen R, Hare S, Lindemann
D, Engelman AN,</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Costa A</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">*,
Cherepanov, P* (2015)</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span><i><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">STRUCTURAL BASIS FOR RETROVIRAL INTEGRATION
INTO NUCLEOSOMES.</span></i><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"><b> </b></span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"><b>Nature</b></span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">523,
366-369. (*Corresponding authors).</span><br>
</span></span></p>
<p class="x_x_MsoNormal" style="margin-bottom:3.0pt"><span style="font-size:11.0pt; line-height:115%; font-family:Arial" lang="EN-US"><span style="font-size:11pt; line-height:16.866666793823242px" lang="EN-US"><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif; color:rgb(0,0,0)">Simon
AC</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif; color:rgb(0,0,0)">, Zhou JC</span><span style="font-size:11pt"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">, Perera RL, van Deursen
F, Evrin C, Ivanova ME, Kilkenny ML,</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span></span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif; color:rgb(0,0,0)">Renault L</span><span style="font-size:11pt"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">,
Kjaer S, Matak-Vinković D, Labib K,</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span></span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif; color:rgb(0,0,0)">Costa A*</span><span style="font-size:11pt"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">,
Pellegrini L*.</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span></span><i style="font-size:11pt"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">A CTF4 TRIMER COUPLES
THE CMG HELICASE TO DNA POLYMERASE α IN THE EUKARYOTIC REPLISOME.</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span></i><span class="x_x_jrnl" style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif; color:rgb(0,0,0)"><b>Nature</b></span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif; color:rgb(0,0,0)">.
2014 Jun 12;510(7504):293-7. (</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif; color:rgb(0,0,0)">*corresponding authors</span><span style="font-size:11pt; font-family:Calibri,Helvetica,sans-serif; color:rgb(0,0,0)">).</span><br>
</span></span></p>
<p class="x_x_MsoNormal" style="margin-bottom:3.0pt"><span style="font-size:11.0pt; line-height:115%; font-family:Arial" lang="EN-US"><span style="font-size:11pt; line-height:16.866666793823242px" lang="EN-US"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Swuec
P, Renault L</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">, Borg A, Shah F, Murphy VJ, van Twest S, Snijders AP, Deans AJ,</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Costa
A</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">.</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span></span><span style="font-family:Calibri,Arial,Helvetica,sans-serif,Helvetica,EmojiFont,"Apple Color Emoji","Segoe UI Emoji",NotoColorEmoji,"Segoe UI Symbol","Android Emoji",EmojiSymbols; font-size:16px"><span style="font-size:11pt; line-height:16.866666793823242px; font-family:Arial" lang="EN-US"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"><i>THE
FA CORE COMPLEX CONTAINS A HOMO-DIMERIC CATALYTIC MODULE FOR THE SYMMETRIC MONO-UBIQUITINATION OF FANCI-FANCD2.
</i><b>Cell Rep</b><i>.</i></span><span style="font-style:italic; font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span></span></span><span style="font-size:11pt; line-height:16.866666793823242px; font-family:Calibri,Helvetica,sans-serif; color:rgb(0,0,0)" lang="EN-US">2017
Jan 17;18(3):611-623.</span></span></p>
<p class="x_x_MsoNormal" style="margin-bottom:3.0pt"><span style="font-size:11.0pt; line-height:115%; font-family:Arial" lang="EN-US"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Zhou JC</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">,
Janska A, </span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Goswami P</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">,
</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Renault L</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">,
</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Abid Ali F</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">, Kotecha A, Diffley JF,
</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">Costa A</span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">.
</span><i><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">CMG-POL EPSILON DYNAMICS SUGGESTS A MECHANISM FOR THE ESTABLISHMENT OF LEADING-STRAND SYNTHESIS IN THE EUKARYOTIC REPLISOME.</span></i><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">
<b>PNAS</b>.</span><span class="x_x_apple-converted-space"><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)"> </span></span><span style="font-family:Calibri,Helvetica,sans-serif; font-size:11pt; color:rgb(0,0,0)">2017
Apr 3. </span></span></p>
<span style="font-size:11pt; color:rgb(0,0,0)"></span>
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<div style="font-size:12pt; word-wrap:break-word"><font style="color:rgb(0,111,201)" face="Trebuchet MS, sans-serif"><b><span style="color:rgb(0,0,0); font-family:Arial,Helvetica,sans-serif; font-size:9pt">Alessandro Costa</span></b></font></div>
<span style="color:rgb(0,0,0); font-family:Arial,Helvetica,sans-serif; font-size:9pt"><b></b></span>
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<b><span style="color:rgb(0,0,0); font-family:Arial,Helvetica,sans-serif; font-size:9pt"></span><span style="font-family:Arial,Helvetica,sans-serif; font-size:9pt; color:rgb(0,0,0)">The Francis Crick Institute</span><br style="font-family:'Trebuchet MS',sans-serif; font-size:16px; color:rgb(0,111,201)">
<span style="color:rgb(0,0,0); font-size:9pt; font-family:Arial,Helvetica,sans-serif">1 Midland Road</span><br style="color:rgb(33,33,33); font-size:13.333333015441895px">
<span style="color:rgb(0,0,0); font-size:9pt; font-family:Arial,Helvetica,sans-serif">London NW1 1AT</span><br style="color:rgb(33,33,33); font-size:13.333333015441895px">
<span style="color:rgb(0,0,0); font-size:9pt; font-family:Arial,Helvetica,sans-serif">United Kingdom</span><br>
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<b><span style="color:rgb(0,0,0); font-family:Arial,Helvetica,sans-serif; font-size:9pt"></span><span style="color:rgb(0,111,201)"><font face="Trebuchet MS, sans-serif"><span style="color:rgb(0,0,0); font-family:Arial,Helvetica,sans-serif; font-size:9pt">Tel:
+ 44 (0) 20 37961812 </span></font></span></b></div>
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<b><span style="color:rgb(0,111,201)"><font face="Trebuchet MS, sans-serif"><span style="color:rgb(0,0,0); font-family:Arial,Helvetica,sans-serif; font-size:9pt"></span></font></span></b><span style="color:rgb(0,0,0); font-family:Arial,Helvetica,sans-serif; font-size:9pt"><b>email:alessandro.costa@crick.ac.uk</b></span></div>
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<p style="color:rgb(112,113,115);font-family: 'Trebuchet MS', 'Lucida Grande'; font-style: italic; font-size: 10pt;">
The Francis Crick Institute Limited is a registered charity in England and Wales no. 1140062 and a company registered in England and Wales no. 06885462, with its registered office at 1 Midland Road London NW1 1AT</p>
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