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ol
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ul
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<b><span style="font-size:14.0pt;
mso-bidi-font-family:"Times New Roman";mso-ansi-language:EN-US">Structural Biology and Drug Development at the University of Oslo<o:p></o:p></span></b></p>
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<span style="font-size: 8pt;"> </span></p>
<p class="MsoNormal" align="center" style="font-size: 14px; text-align: center;">
<b><span style="font-size: 14pt;">3 Postdoctoral Fellowships<o:p></o:p></span></b></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify;"><span style="font-size: 11pt;"> </span></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify;"><span style="font-size: 11pt;">Three postdoctoral positions (three years, extendable) are available in the Group of Structural Biology and Drug Development
</span><span style="font-size:11.0pt;mso-ansi-language:EN-US">(Luecke group) at the Centre for Molecular Medicine Norway (NCMM) in Oslo.</span><o:p></o:p></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify;"><span style="font-size:11.0pt;mso-bidi-font-family:"Times New Roman";mso-ansi-language:
EN-US"> </span></p>
<p class="Default" style="font-size: 14px; text-align: justify;"><span style="font-size:11.0pt;font-family:Cambria;mso-ascii-theme-font:minor-latin;
mso-hansi-theme-font:minor-latin;mso-ansi-language:EN-US">The Group for Structural Biology and Drug Development
investigates medically relevant proteins and protein complexes using biophysical, biochemical and structural approaches. The projects aim at understanding structure-function relationships with an emphasis on drug discovery. We employ a variety of biochemical
and biophysical techniques (x-ray crystallography, single particle cryo electron microscopy, DSF, ITC, SPR, HDX-MS, SAXS, molecular dynamics simulations etc.). Specific, externally funded projects include inhibitor discovery targeting the
<i>Helicobacter pylori</i> pH acclimation system (a pH-gated urea channel and a cytoplasmic urease<sup>1</sup>), and discovery of compounds that reactivate p53 cancer mutants
<i>in vitro</i> and <i>in vivo</i><sup>2</sup>.<o:p></o:p></span></p>
<p class="Default" style="font-size: 14px; text-align: justify;"><span style="font-size:11.0pt;font-family:Cambria;mso-ascii-theme-font:minor-latin;
mso-hansi-theme-font:minor-latin;mso-ansi-language:EN-US"> </span></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify;"><span style="font-size: 11pt;">The positions are available
</span><span style="font-size: 11pt;">immediately. We seek highly motivated</span><span style="font-size: 11pt;"> individuals with an excellent track record and experience in protein purification and biophysical and biochemical characterization of proteins
and protein complexes, preferably including membrane proteins. Knowledge of one or more structural biology technique (x-ray crystallography, cryo electron microscopy or NMR) is required. </span><span style="font-size:11.0pt;mso-ansi-language:EN-US">Postdoctoral
fellows will be supported in developing their own research area on their path to independence.
</span><span style="font-size:11.0pt;mso-bidi-font-family:"Times New Roman";mso-ansi-language:
EN-US">We offer a stimulating environment with excellent working and social benefits in the Happiest Country on Earth.<o:p></o:p></span></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify;"><span style="font-size:11.0pt;mso-bidi-font-family:"Times New Roman";mso-ansi-language:
EN-US"> </span></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify;"><b><span style="font-size:11.0pt;mso-bidi-font-family:"Times New Roman";mso-ansi-language:
EN-US">The ideal candidate will have:<o:p></o:p></span></b></p>
<p class="MsoListParagraphCxSpFirst" style="font-size: 14px; margin-left: 35.7pt; text-align: justify; text-indent: -17.85pt;">
<!--[if !supportLists]--><span style="font-size: 11pt;">·<span style="font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">
</span></span><!--[endif]--><span style="font-size:11.0pt;mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-US">A Ph.D. degree in biochemistry, biophysics, chemistry, or a related area<o:p></o:p></span></p>
<p class="MsoListParagraphCxSpLast" style="font-size: 14px; margin-left: 35.7pt; text-align: justify; text-indent: -17.85pt;">
<!--[if !supportLists]--><span style="font-size: 11pt;">·<span style="font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">
</span></span><!--[endif]--><span style="font-size:11.0pt;mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-US">Hands-on experience with extraction and purification of proteins and assembly of protein complexes (membrane protein experience preferred)<o:p></o:p></span></p>
<p class="MsoNormal" style="font-size: 14px; margin-left: 35.7pt; text-align: justify; text-indent: -17.85pt; background-color: white; background-position: initial initial; background-repeat: initial initial;">
<!--[if !supportLists]--><span style="font-size: 11pt;">·<span style="font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">
</span></span><!--[endif]--><span style="font-size: 11pt;">Ability to independently perform experiments, analyze and interpret results<o:p></o:p></span></p>
<p class="MsoNormal" style="font-size: 14px; margin-left: 35.7pt; text-align: justify; text-indent: -17.85pt; background-color: white; background-position: initial initial; background-repeat: initial initial;">
<!--[if !supportLists]--><span style="font-size: 11pt;">·<span style="font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">
</span></span><!--[endif]--><span style="font-size: 11pt;">Documented ability to write scientific manuscripts (one or more first author papers from Ph.D. and postdoctoral studies will be highly valued)<o:p></o:p></span></p>
<p class="MsoNormal" style="font-size: 14px; margin-left: 35.7pt; text-align: justify; text-indent: -17.85pt; background-color: white; background-position: initial initial; background-repeat: initial initial;">
<!--[if !supportLists]--><span style="font-size: 11pt;">·<span style="font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">
</span></span><!--[endif]--><span style="font-size: 11pt;">Excellent English interpersonal, communication and writing skills<o:p></o:p></span></p>
<p class="MsoListParagraph" style="font-size: 14px; margin-left: 35.7pt; text-align: justify; text-indent: -17.85pt;">
<!--[if !supportLists]--><span style="font-size: 11pt;">·<span style="font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">
</span></span><!--[endif]--><span style="font-size:11.0pt;mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-US">Ability to operate as a team player in a multi-disciplinary environment<o:p></o:p></span></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify; background-color: white; background-position: initial initial; background-repeat: initial initial;">
<b><span style="font-size: 11pt;"> </span></b></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify; background-color: white; background-position: initial initial; background-repeat: initial initial;">
<b><span style="font-size: 11pt;">Application via website required (</span></b><b><span style="font-size: 11pt;">link will be published January 2, 2018</span></b><b><span style="font-size: 11pt;">) and must include</span></b><span style="font-size: 11pt;">:<o:p></o:p></span></p>
<p class="MsoNormal" style="font-size: 14px; margin-left: 35.7pt; text-align: justify; text-indent: -17.85pt; background-color: white; background-position: initial initial; background-repeat: initial initial;">
<!--[if !supportLists]--><span style="font-size: 10pt;">·<span style="font-size: 7pt; line-height: normal; font-family: 'Times New Roman';">
</span></span><!--[endif]--><span style="font-size: 11pt;">Cover Letter stating motivation and research interests<o:p></o:p></span></p>
<ul style="font-size: 14px; margin-top: 0cm;" type="disc">
<li class="MsoNormal" style="text-align: justify; background-color: white; background-position: initial initial; background-repeat: initial initial;">
<span style="font-size:11.0pt;mso-fareast-font-family:"Times New Roman";
mso-bidi-font-family:Arial;mso-ansi-language:EN-US">A detailed C.V.<o:p></o:p></span></li><li class="MsoNormal" style="text-align: justify; background-color: white; background-position: initial initial; background-repeat: initial initial;">
<span style="font-size:11.0pt;mso-fareast-font-family:"Times New Roman";
mso-bidi-font-family:Arial;mso-ansi-language:EN-US">A complete list of scientific publications with brief statement of candidate contribution<o:p></o:p></span></li><li class="MsoNormal" style="text-align: justify; background-color: white; background-position: initial initial; background-repeat: initial initial;">
<span style="font-size:11.0pt;mso-fareast-font-family:"Times New Roman";
mso-bidi-font-family:Arial;mso-ansi-language:EN-US">List of references (name, institution, e-mail, telephone number and relation to candidate)<o:p></o:p></span></li></ul>
<p class="MsoNormal" style="font-size: 14px; text-align: justify; background-color: white; background-position: initial initial; background-repeat: initial initial;">
<span style="font-size: 11pt;"> </span></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify; background-color: white; background-position: initial initial; background-repeat: initial initial;">
<b><span style="font-size: 11pt;">Salary</span></b><span style="font-size: 11pt;">: Postdoctoral Research Fellow (SKO 1352) with a salary level of NOK486,100–567,100 (app. €51,800-€60,400) per year, depending on qualifications.<o:p></o:p></span></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify;"><b><span style="font-size: 11pt;"> </span></b></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify;"><b><span style="font-size: 11pt;">Inquiries:<o:p></o:p></span></b></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify;"><span style="font-size: 11pt;">About the position and projects: Prof. Hartmut “Hudel” Luecke (<a href="mailto:hudel@ncmm.uio.no">hudel@ncmm.uio.no</a>).<o:p></o:p></span></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify;"><span style="font-size: 11pt;">About
</span><span style="font-size:11.0pt;mso-bidi-font-family:
"Times New Roman";mso-ansi-language:EN-US">administrative aspects of the application: Nina Modahl (<a href="mailto:ninam@ncmm.uio.no">ninam@ncmm.uio.no</a>).<o:p></o:p></span></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify;"><span style="font-size:11.0pt;mso-bidi-font-family:"Times New Roman";mso-ansi-language:
EN-US"> </span></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify;"><span style="font-size: 11pt;">Online applications will be evaluated starting January 15, 2018.<o:p></o:p></span></p>
<p class="MsoNormal" style="font-size: 14px; text-align: justify;"><span style="font-size: 11pt;"> </span></p>
<p class="MsoNormal" style="text-align: justify;"><sup style="font-size: 10px;">1</sup><span style="font-size: 8pt;">Strugatsky
<i>et al.</i> “Structure of the proton-gated urea channel from the gastric pathogen
<i>Helicobacter pylori</i>” (2013) <i>Nature</i> <b>493</b>, 255–258.<o:p></o:p></span></p>
<p class="MsoNormal" style="text-align: justify;"><sup style="font-size: 10px;">2</sup><span style="font-size: 8pt;">Wassman
<i>et al.</i> ”Computational Identification of a Transiently Open L1/S3 Pocket for p53 Cancer Mutant Reactivation” (2013)
<i>Nature Communications</i> <b>4</b>, article number 1407.<o:p></o:p></span></p>
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