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<p class="MsoNormal"><span style="font-size:14.0pt">Dear Friends and Colleagues,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Now that the NCI-supported National Cryo-EM Facility (NCEF) has been operational for a few months, I want to provide a brief update on activities at the facility since its launch on May 15, 2017.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">The facility provides access to a Titan Krios electron microscope at no cost to researchers within the extramural academic community. The decision about suitability of projects for data collection is made
on a first-come, first-served basis by NCEF staff, and is based solely on the quality of the screening images provided. Users must also provide a couple of sentences summarizing the general relevance of their project to basic or applied cancer research.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Users are not required to have current or past funding support from either the NCI or NIH in order to send in an application.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">The facility currently has one Titan Krios microscope that is equipped with a phase plate as well as pre-GIF Falcon 3EC and post-GIF K2-Summit direct electron detectors. Use of the facility is growing rapidly
and the microscope is being used at essentially maximum capacity with waiting times of less than a month at present. To meet the growing demand, we will add a second Titan Krios microscope next summer, which should be available for use by Fall 2018.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">If you have any questions about the facility or access to its resources, please visit
<a href="http://www.cancer.gov/research/resources/cryoem">http://www.cancer.gov/research/resources/cryoem</a> or send an e-mail to
<a href="mailto:nci-ncef@nih.gov">nci-ncef@nih.gov</a>. <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Sincerely,<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Sriram Subramaniam <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">Scientific Advisor<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">National Cryo-EM Facility<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt">National Cancer Institute/NIH<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:14.0pt"><o:p> </o:p></span></p>
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