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<p class="MsoNormal" style="text-align:justify"><b class=""><span style="font-family:"Arial",sans-serif" class="">Postdoctoral position to study dynein structure and mechanism available at UC San Diego<o:p class=""></o:p></span></b></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family: Arial, sans-serif;" class="">A postdoctoral position is available in the labs of Samara Reck-Peterson and Andres Leschziner at UC San Diego. The two groups have a long-standing collaboration
to study the mechanism and regulation of cytoplasmic dynein using a combination of biochemistry, single-molecule biophysics, cryo-electron microscopy (cryo-EM) and cell biology (1-6).</span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif" class="">The two laboratories are fully equipped for all aspects of biochemistry, cell biology, single-molecule biophysics and cryo-EM. Dr. Reck-Peterson is the faculty
director of the newly-formed Nikon Imaging Center at UC San Diego, which will house five state-of-the-art light microscopes. In addition, the Reck-Peterson lab is equipped with two total internal reflection microscopes for single-molecule imaging and recently
built a lattice light sheet microscope for live-cell imaging. The Leschziner lab is a core member of the UC San Diego Cryo-EM Facility, which houses their own FEI Talos Arctica equipped with a K2 Summit, an FEI Polara, an FEI Titan Krios (to be installed in
December), which will be equipped with a K2 Summit and a Quantum energy filter. The Facility also has a cryo-capable Tecnai Sphera used for general screening.</span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family: Arial, sans-serif; text-indent: 0.5in;" class="">Candidates must have a Ph.D. at the start of the postdoctoral appointment. Research experience in the following area(s) is particularly
desirable: (1) cryo-EM and/or (2) biochemistry of large protein complexes.</span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family:"Arial",sans-serif" class="">Potential candidates should send a PDF including cover letter, curriculum vitae with list of publications, and names of three referees to:<o:p class=""></o:p></span></p>
<p class="MsoNormal" style="text-indent: 0px; text-align: justify;"><span style="text-indent: 0.5in; font-family: Arial, sans-serif;" class=""><span class="Apple-tab-span" style="white-space:pre"></span>Professor Samara Reck-Peterson - </span><i style="text-indent: 0.5in;" class=""><span style="font-family:"Arial",sans-serif" class="">email</span></i><span style="text-indent: 0.5in; font-family: Arial, sans-serif;" class="">:
<b class=""><a href="mailto:sreckpeterson@ucsd.edu" class="">sreckpeterson@ucsd.edu</a></b></span></p>
<p class="MsoNormal" style="text-indent: 0px; text-align: justify;"><span style="text-indent: 0.5in; font-family: Arial, sans-serif;" class=""><span class="Apple-tab-span" style="white-space:pre"></span>Professor Andres Leschziner - </span><i style="text-indent: 0.5in;" class=""><span style="font-family:"Arial",sans-serif" class="">email</span></i><span style="text-indent: 0.5in; font-family: Arial, sans-serif;" class="">:
<b class=""><a href="mailto:aleschziner@ucsd.edu" class="">aleschziner@ucsd.edu</a></b></span></p>
<p class="MsoNormal" style="text-align:justify"><span style="font-family: Arial, sans-serif;" class="">Applications will be reviewed as they are received and until the position is filled.</span><span style="font-family: Arial, sans-serif;" class="">
</span><span style="font-family: Arial, sans-serif;" class="">UC San Diego is an equal opportunity employer committed to diversity.</span></p>
<div class=""><br class="">
</div>
<div style="text-align: justify;" class="">
<ol class="">
<li class=""><span style="font-size: 11px; font-family: Arial;" class="">DeSantis ME#</span><span style="font-size: 11px; font-family: Arial;" class="">, Cianfrocco MA</span><span style="font-size: 11px; font-family: Arial;" class="">#</span><span style="font-size: 11px; font-family: Arial;" class="">,</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">Htet
ZM</span><span style="font-size: 11px; font-family: Arial;" class="">#</span><span style="font-size: 11px; font-family: Arial;" class="">, Tran PT, Reck-Peterson SL* and Leschziner AE* (2017) Lis1</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">has
two opposing modes of regulating cytoplasmic</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">dynein </span><span style="font-size: 11px; font-family: Arial;" class=""><b class="">Cell</b> 170:
1197-1208.</span></li><li class=""><span style="font-size: 11px; font-family: Arial;" class="">Cianfrocco MA#</span><span style="font-size: 11px; font-family: Arial;" class="">, DeSantis ME</span><span style="font-size: 11px; font-family: Arial;" class="">#</span><span style="font-size: 11px; font-family: Arial;" class="">,</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">Leschziner
AE and Reck-Peterson SL (2015). Mechanism and regulation of</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">cytoplasmic dynein. </span><span style="font-size: 11px; font-family: Arial;" class=""><b class="">Annu.
Rev. Cell Dev. Biol</b></span><span style="font-size: 11px; font-family: Arial;" class="">.</span><span style="font-size: 11px; font-family: Arial;" class=""> 31:</span><span style="font-size: 11px; font-family: Arial;" class=""> 83-108.</span></li><li class=""><span style="font-size: 11px; font-family: Arial;" class="">Toropova K#</span><span style="font-size: 11px; font-family: Arial;" class="">, Zou S</span><span style="font-size: 11px; font-family: Arial;" class="">#</span><span style="font-size: 11px; font-family: Arial;" class="">,</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">Roberts
AJ, Redwine WB, Goodman BS, Reck-Peterson SL* and Leschziner AE*</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">(2014). Lis1 regulates dynein by sterically blocking its</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">mechanochemical
cycle.</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class=""><b class="">eLife</b></span><span style="font-size: 11px; font-family: Arial;" class=""> 3:e03372</span></li><li class=""><span style="font-size: 11px; font-family: Arial;" class="">Derr N#</span><span style="font-size: 11px; font-family: Arial;" class="">, Goodman BS</span><span style="font-size: 11px; font-family: Arial;" class="">#</span><span style="font-size: 11px; font-family: Arial;" class="">,</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">Jungmann
R, Leschziner AE, Shih W and Reck-Peterson SL (2012). Tug of war in</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">motor protein ensembles revealed with a</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">programmable
DNA origami scaffold. </span><span style="font-size: 11px; font-family: Arial;" class=""><b class="">Science</b></span><span style="font-size: 11px; font-family: Arial;" class=""> 338: 662.</span></li><li class=""><span style="font-size: 11px; font-family: Arial;" class="">Redwine WB#</span><span style="font-size: 11px; font-family: Arial;" class="">, Hernandez-Lopez RH</span><span style="font-size: 11px; font-family: Arial;" class="">#</span><span style="font-size: 11px; font-family: Arial;" class="">,</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">Zou
S, Huang J, Reck-Peterson SL and Leschziner AE (2012). Structural basis for</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">microtubule binding and release by</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">dynein. </span><span style="font-size: 11px; font-family: Arial;" class=""><b class="">Science</b> 337:
1532</span></li><li class=""><span style="font-size: 11px; font-family: Arial;" class="">Huang J#</span><span style="font-size: 11px; font-family: Arial;" class="">, Roberts AJ</span><span style="font-size: 11px; font-family: Arial;" class="">#</span><span style="font-size: 11px; font-family: Arial;" class="">,</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">Leschziner
AE and Reck-Peterson SL (2012). Lis1 acts as a “clutch” between the</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">ATPase and and microtubule-binding domains of the</span><span style="font-size: 11px; font-family: Arial;" class=""> </span><span style="font-size: 11px; font-family: Arial;" class="">dynein
motor. </span><span style="font-size: 11px; font-family: Arial;" class=""><b class="">Cell</b></span><span style="font-size: 11px; font-family: Arial;" class=""> 150(5): 975</span></li></ol>
</div>
<div style="text-align: justify;" class=""><span style="font-family: Arial; font-size: 11px;" class=""># equal contribution</span></div>
<div style="text-align: justify;" class=""><span style="font-size: 11px; font-family: Arial;" class="">* co-corresponding authors</span><span style="font-size: 11px; font-family: Arial;" class=""> </span></div>
<p class="MsoNormal" style="text-align:justify"><span style="font-size:11.0pt;
font-family:"Arial",sans-serif" class=""> </span></p>
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