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Postdoctoral Fellowships in Structural Biology and Drug Development</h2>
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Two postdoctoral positions (three years) are available in the Group of Structural Biology and Drug Development (<strong>Luecke group,
<a href="mailto:hudel@ncmm.uio.no">hudel@ncmm.uio.no</a></strong>) at the Nordic Centre for Molecular Medicine (NCMM), the Norwegian node in the Nordic EMBL Partnership for Molecular Medicine.</p>
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The Group for Structural Biology and Drug Development investigates medically relevant proteins and protein complexes using biophysical, biochemical and structural approaches. The projects aim at understanding structure-function relationships with an emphasis
on drug discovery. We employ a variety of biochemical and biophysical techniques (x-ray crystallography, single particle cryo electron microscopy, SAXS, ITC, SPR, molecular dynamics simulations etc.). Specific projects include the <em>Helicobacter pylori</em> pH
acclimation system of a pH-gated urea channel and a cytoplasmic urease and discovery of compounds that reactivate p53 cancer mutants <em>in vitro</em> and <em>in vivo</em>.</p>
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Strugatsky, D., McNulty, R.M., Munson, K., Chen, C.-K., Soltis, S.M., Sachs, G., Luecke H. “Structure of the proton-gated urea channel from the gastric pathogen <em>Helicobacter pylori</em>” (2013) <em>Nature</em> <strong>493</strong>, 255–258.<br>
Luecke, H. & Sachs, G. “<em>Helicobacter pylori</em>’s Achilles’ Heel” (2013) <em>Immuno-Gastroenterology</em> <strong>2</strong>, 76.<br>
McNulty, R., Ulmschneider, J.P., Luecke, H., Ulmschneider, M.B. ”Mechanisms of molecular transport through the urea channel of Helicobacter pylori” (2013) <em>Nature Communications</em> <strong>4</strong>, article number 2900.</p>
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<strong>Postdoctoral fellow</strong></p>
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The positions are available starting January 2018. We seek highly motivated individuals with an excellent track record and experience in protein purification and biophysical and biochemical characterization of proteins and protein complexes, preferably including
membrane proteins. Knowledge of structural biology techniques (x-ray crystallography and/or cryo electron microscopy) is required. Postdoctoral fellows are expected to develop their own research area on their path to independence. We offer a stimulating
environment with excellent working and social benefits in the happiest country on Earth.</p>
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<strong>The ideal candidate will have:</strong> </p>
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A Ph.D. degree in biochemistry, chemistry, molecular biology or a related area</li><li style="margin: 0px 0px 0px 15px; padding: 0px; list-style: disc outside; font-size: 16px; line-height: 20px;">
Hands-on experience with extraction and purification of proteins and assembly of protein complexes (membrane protein experience preferred)</li><li style="margin: 0px 0px 0px 15px; padding: 0px; list-style: disc outside; font-size: 16px; line-height: 20px;">
Ability to independently perform experiments, analyze and interpret results</li><li style="margin: 0px 0px 0px 15px; padding: 0px; list-style: disc outside; font-size: 16px; line-height: 20px;">
Documented ability to write scientific manuscripts (one or more first author papers from Ph.D. and postdoctoral studies will be highly valued)</li><li style="margin: 0px 0px 0px 15px; padding: 0px; list-style: disc outside; font-size: 16px; line-height: 20px;">
Excellent interpersonal/communication skills</li><li style="margin: 0px 0px 0px 15px; padding: 0px; list-style: disc outside; font-size: 16px; line-height: 20px;">
Excellent written and oral English</li><li style="margin: 0px 0px 0px 15px; padding: 0px; list-style: disc outside; font-size: 16px; line-height: 20px;">
Ability to operate as a team player in a multi-disciplinary environment</li></ul>
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<strong>The online application (deadline 15 September 2017) must include:</strong></p>
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A cover letter stating motivation and research interests</li><li style="margin: 0px 0px 0px 15px; padding: 0px; list-style: disc outside; font-size: 16px; line-height: 20px;">
A C.V.</li><li style="margin: 0px 0px 0px 15px; padding: 0px; list-style: disc outside; font-size: 16px; line-height: 20px;">
A complete list of scientific publications</li><li style="margin: 0px 0px 0px 15px; padding: 0px; list-style: disc outside; font-size: 16px; line-height: 20px;">
List of references (name, relation to candidate, e-mail and telephone number)</li><li style="margin: 0px 0px 0px 15px; padding: 0px; list-style: disc outside; font-size: 16px; line-height: 20px;">
<a href="https://www.jobbnorge.no/en/available-jobs/job/141110/postdoctoral-fellowships-in-structural-biology-and-drug-development" style="font-family: Calibri, sans-serif; font-size: 14px;">https://www.jobbnorge.no/en/available-jobs/job/141110/postdoctoral-fellowships-in-structural-biology-and-drug-development</a></li></ul>
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<strong>Salary:</strong></p>
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The postdoctoral position will be placed as Postdoctoral Research Fellow (SKO 1352) with a salary level of NOK486,100–569,000 (app. €51,800-€60,900) per year, depending on qualifications.</p>
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<strong>Inquiries:</strong></p>
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About the position: Prof. Hartmut “Hudel” Luecke (<a href="mailto:hudel@ncmm.uio.no" style="color: rgb(0, 124, 177); text-decoration: none; text-shadow: rgb(255, 255, 255) 0.05em 0px 0px, rgb(255, 255, 255) -0.05em 0px 0px, rgb(255, 255, 255) 0px 0.05em 0px, rgb(255, 255, 255) 0px -0.05em 0px, rgb(255, 255, 255) 0.1em 0px 0px, rgb(255, 255, 255) -0.1em 0px 0px, rgb(255, 255, 255) 0px 0.1em 0px, rgb(255, 255, 255) 0px -0.1em 0px; background-image: linear-gradient(to right, currentcolor 0%, currentcolor 100%); background-repeat: repeat-x; background-position: center bottom 0.05em; background-size: 100% 0.05em; border: 1px solid transparent;">hudel@ncmm.uio.no</a>).<br>
About administrative aspects of the application: Nina Modahl (<a href="mailto:ninam@ncmm.uio.no" style="color: rgb(0, 124, 177); text-decoration: none; text-shadow: rgb(255, 255, 255) 0.05em 0px 0px, rgb(255, 255, 255) -0.05em 0px 0px, rgb(255, 255, 255) 0px 0.05em 0px, rgb(255, 255, 255) 0px -0.05em 0px, rgb(255, 255, 255) 0.1em 0px 0px, rgb(255, 255, 255) -0.1em 0px 0px, rgb(255, 255, 255) 0px 0.1em 0px, rgb(255, 255, 255) 0px -0.1em 0px; background-image: linear-gradient(to right, currentcolor 0%, currentcolor 100%); background-repeat: repeat-x; background-position: center bottom 0.05em; background-size: 100% 0.05em; border: 1px solid transparent;">ninam@ncmm.uio.no</a>).</p>
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<div><a href="https://www.jobbnorge.no/en/available-jobs/job/141110/postdoctoral-fellowships-in-structural-biology-and-drug-development">https://www.jobbnorge.no/en/available-jobs/job/141110/postdoctoral-fellowships-in-structural-biology-and-drug-development</a></div>
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