<div dir="ltr"><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px">Schrödinger, a computational chemistry company funded in part by Bill Gates, has over 300 engineers, computational chemists, medicinal chemists, structural biologists, biochemists, biologists and support staff, all dedicated to revolutionizing drug discovery through the development and use of breakthrough computational methods. Through significant long-term investments in basic research, we have made scientific advancements across many areas of drug discovery and have contributed hundreds of peer-reviewed scientific publications, which are frequently among the most heavily cited in their fields. These advancements have been instrumental in the success of our structure-based drug discovery efforts (<a href="https://www.schrodinger.com/publications" style="margin:0px;padding:0px;color:rgb(0,135,204);text-decoration-line:none">https://www.schrodinger.com/publications</a>,  <a href="https://www.schrodinger.com/news" style="margin:0px;padding:0px;color:rgb(0,135,204);text-decoration-line:none">https://www.schrodinger.com/news</a>).  </p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px">We are seeking an expert in developing and applying methods to create and refine structural models created from near-atomic-resolution single-particle cryo-EM experiments of proteins. The ideal candidate will have a demonstrated ability to develop and validate algorithms to locally refine protein models using a combination of experimental data and statistical or physical potentials. This position is based in our New York office.</p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px"><strong style="margin:0px;padding:0px">Responsibilities:</strong></p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px">- Work as part of a collaborative team to create and validate new technologies designed to produce high-confidence structural models from near-atomic-resolution cryo-EM of proteins</p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px">- Work with the drug discovery group to deploy these new technologies to active projects</p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px"><strong style="margin:0px;padding:0px">Requirements:</strong></p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px">- Ph.D. in computational chemistry, biochemistry, biophysics, or a related field with peer-reviewed publications in the field</p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px">- Experience working with and/or extending existing protein structure prediction or homology modeling packages such as Rosetta, Modeller, Prime, etc.</p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px">- Experience working with data from single-particle cryo-electron microscopy</p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px">- Experience with scripted or compiled programming languages</p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px">- Excellent communication skills and a demonstrated ability to work as part of a team</p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px"><strong style="margin:0px;padding:0px">Preferred Skills:</strong></p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px">- Experience working with pharmaceutically relevant systems such as kinases, GPCRs, transferases, etc</p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px">- Broad knowledge of computational chemistry techniques and their applications to the drug discovery process</p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px">- Object oriented software development experience following good engineering practices </p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px">Benefits include medical, dental, 401(k), flexible spending account, vacation, tuition reimbursement, and a flexible work schedule.</p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px"><em style="margin:0px;padding:0px">Schrödinger is an equal opportunity employer.</em></p><p style="margin:0px 0px 9px;padding:5px;color:rgb(0,0,0);font-family:"helvetica neue",helvetica,arial,sans-serif;font-size:12px"><span style="margin:0px;padding:0px">If you are interested, please apply through our website: <a href="https://www.schrodinger.com/careers/scientists/senior-scientist-cryo-em-model-fitting">https://www.schrodinger.com/careers/scientists/senior-scientist-cryo-em-model-fitting</a></span></p><div><br></div>-- <br><div class="gmail_signature"><div dir="ltr"><div class="gmail_signature"><div dir="ltr">Frank Pagliaro<div><span style="color:rgb(80,0,80);font-size:12.8px">Schrödinger, Inc.</span><br></div><div><span style="color:rgb(80,0,80);font-size:12.8px">120 W 45th St</span></div><div><span style="color:rgb(80,0,80);font-size:12.8px">New York, NY 10036</span></div><div><span style="color:rgb(80,0,80);font-size:12.8px">(774) 212-2478</span></div><div><span style="color:rgb(80,0,80);font-size:12.8px"><a href="mailto:frank.pagliaro@schrodinger.com" target="_blank">frank.pagliaro@schrodinger.com</a></span></div></div></div></div></div>
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