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<p><br>
>From the ELIXIR-Spanish node, the Instruct Image Processing Center at CNB-CSIC and the Electron Microscopy Data Bank (EMDB) at the European Bioinformatics Institute (EMBL-EBI), we are very glad to present to the community the start of a new tool, 3DBIONOTES, available at<br>
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<a href="http://3dbionotes.cnb.csic.es" target="_blank">http://3dbionotes.cnb.csic.es</a><br>
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and accessible from EMDB entries with fitted atomic models<br>
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<a href="http://emdb-empiar.org" target="_blank">http://emdb-empiar.org</a>, e.g., <a href="http://emdb-empiar.org/emd-2984" target="_blank">http://emdb-empiar.org/emd-2984</a>.<br>
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3DBIONOTES is a web tool that offers a unified view of EMDB, PDB and UNIPROT, providing an interface to explore protein structure (EM map and atomic models) together with biomedical annotations. In this way, structural information is enriched with a wide range of specific protein features, including post-translational modifications, epitope binding sites and disease related genetic variants. Protein annotations are displayed interactively at sequence and structural level, allowing users to easily and interactively correlate biomedical annotations with protein sequence and structure, helping to analyze functional implications.<br>
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For those atomic models not yet deposited at EMDB, access to 3DBIONOTES is provided at<br>
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<a href="http://3dbionotes-ws.cnb.csic.es" target="_blank">http://3dbionotes-ws.cnb.csic.es</a>.<br>
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We are constantly improving our tools and your help will be more than welcome. Please, contact us with any suggestion, missing functionality or other type of data that you would like or think that could be interesting to integrate in the application.<br>
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best wishes,<br>
BCU team</p>
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Joan Segura Mora e-mail:jsegura@cnb.csic.es<br>
Biocomputing unit <a href="http://biocomp.cnb.csic.es" target="_blank">http://biocomp.cnb.csic.es</a><br>
National Center of Biotechnology (CSIC)<br>
c/Darwin, 3<br>
Campus Universidad Autónoma (Cantoblanco) Tlf: +34 91 585 4510<br>
28049 MADRID (SPAIN) Fax: +34 91 585 4506<br>
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