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<p class="MsoNormal">An exciting opportunity has arisen to join the laboratory of Professor Christian Speck in the Institute of Clinical Sciences, Faculty of Medicine at the Hammersmith Campus of Imperial College London (<a href="http://www.specklab.com">http://www.specklab.com</a>/).
<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">This is a full-time, three year position <b>(HM2016209</b>) with a salary range of : £36,070 to £40,030 per annum.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">This is an ideal opportunity for an enthusiastic and highly creative scientist to join a dynamic research team with excellent collaborators and facilities. The successful applicant will use cutting-edge biochemical and structural approaches
to discover fundamental biological mechanisms of human DNA replication factors in assembly of the replication fork and regulated heterochromatin formation with therapeutic potential.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">The applicant will investigate how human replication factors function and how they are regulated, which is crucial to understand how cancer development is initiated and in order to develop novel replication inhibitors with potential as
chemotherapeutic drugs. The research will involve design of constructs, expression and purification of proteins & protein complexes using bacteria and insect cells (multi-bac). The purified factors will be used for the development of novel biochemical assays,
structure determination by cryo-electron microscopy, analysis of protein dynamics by FRET assays and inhibitor development. The applicant will be working as part of a team, and will have ample opportunity to drive the project’s direction in a creative way.
<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Candidates will enjoy their interactions with group members specialised in biochemistry, cryo-EM or
<i>in vivo</i> approaches generating a collaborative and productive atmosphere. The lab is very well equipped for biochemistry and the structural EM work. and has direct access to electron microscopes at the local MRC facility, the fully-equipped cryo-EM facility
at Imperial College London and regular access to the Titan Krios. Richard Henderson (LMB) will advise the postdoctoral fellow for cryo-EM.
<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">By joining the group, the candidate will not only participate in high profile research projects, but will be also directly mentored by Professor Speck in successful grant writing, networking and publishing. This will prepare the post holder
to make the next career move. <o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">The candidate should have a PhD in Biochemistry, Molecular/Structural Biology, a strong publication record and extensive expertise in protein biochemistry and/or cryo-EM. A background in the areas of molecular machines, the chromatin field,
structure determination & modelling, DNA replication, cell cycle, DNA repair, and the broader area of genome stability would be an advantage, but is not necessary. The latest expected start date is early/mid 2017.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">For informal inquiries or questions please contact Professor Christian Speck directly (<a href="mailto:chris.speck@imperial.ac.uk">chris.speck@imperial.ac.uk</a>).<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Apply online via our website at <a href="http://www3.imperial.ac.uk/employment">
http://www3.imperial.ac.uk/employment</a> (select “Job Search” then enter the job title or vacancy reference number into “Keywords”). Please complete and upload an application form as directed
<b>quoting the appropriate reference number (HM2016209).<o:p></o:p></b></p>
<p class="MsoNormal"><b><o:p></o:p></b></p>
<p class="MsoNormal">Alternatively, if you are unable to apply online, please email
<a href="mailto:Katie.Poole@imperial.ac.uk">Katie.Poole@imperial.ac.uk</a> to request an application form.<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b><span lang="EN-US">Closing Date: 19 December 2016 (Midnight)<o:p></o:p></span></b></p>
<p class="MsoNormal"><span lang="EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal">Best wishes,<o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal">Christian<o:p></o:p></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:DE">__________________________________________</span></i><i><span style="font-size:12.0pt;mso-fareast-language:DE"><o:p></o:p></span></i></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:DE">Professor Christian Speck, PhD, FRSB<o:p></o:p></span></i></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:DE">Chair in Genome Biochemistry & Molecular Biology</span></i><span style="mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:DE">Wellcome Trust Investigator</span></i><span style="mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:DE"><o:p> </o:p></span></i></p>
<p class="MsoNormal"><span style="mso-fareast-language:DE">Imperial College London<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:DE">Faculty of Medicine<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:DE">Institute of Clinical Sciences (CRB room 3006)<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:DE">Hammersmith Hospital Campus<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:DE">Du Cane Road<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:DE">London W12 0NN<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:DE">Tel: 0044 20 8383 3387
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:DE">Mobile: 0044 796 181 5557<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal"><i><span style="mso-fareast-language:DE">email: <span style="color:blue">
<a href="mailto:christian.speck@imperial.ac.uk"><span style="color:blue;font-style:normal">christian.speck@imperial.ac.uk</span></a></span></span></i><span style="mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><i><span style="font-size:10.0pt;font-family:"Arial",sans-serif;mso-fareast-language:DE">website:
</span></i><span style="font-size:10.0pt;font-family:"Arial",sans-serif;mso-fareast-language:DE"><a href="http://www.specklab.com/"><i><span style="color:blue">www.specklab.com</span></i></a><i>
<span style="color:red"><o:p></o:p></span></i></span></p>
<p class="MsoNormal"><i><span style="font-size:10.0pt;font-family:"Arial",sans-serif;mso-fareast-language:DE">Imperial College website:</span></i><span style="mso-fareast-language:DE">
<i><a href="http://www.imperial.ac.uk/people/chris.speck"><span style="color:blue">www.imperial.ac.uk/people/chris.speck</span></a></i></span><span style="mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:DE"><o:p> </o:p></span></p>
<p class="MsoNormal"><span style="mso-fareast-language:EN-GB"><img border="0" width="354" height="111" id="Picture_x0020_1" src="cid:image001.jpg@01D24CC2.DF2E3700" alt="http://www.wellcome.ac.uk/stellent/groups/corporatesite/@policy_communications/documents/web_document/wtvm050463.jpg"></span><a href="http://www.athenaswan.org.uk/" target="_blank"><span style="color:blue;mso-fareast-language:EN-GB;text-decoration:none"><img border="0" width="168" height="92" id="Picture_x0020_2" src="cid:image002.png@01D24CC2.DF2E3700" alt="Athena Swan Bronze Award Logo"></span></a><span style="mso-fareast-language:DE"><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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