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<p class="MsoNormal">Pfizer Structural Biology group (Groton, CT) has a Postdoctoral Fellow opening for cryo-EM and the candidate can apply the job in the link below.<o:p></o:p></p>
<p class="MsoNormal"><span style="color:#222222;background:white">Thanks in advance for your interest!<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#222222;background:white">Seungil Han<o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><a href="http://www.pfizercareers.com">www.pfizercareers.com</a><span style="color:#1F497D">
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN"><o:p> </o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:8.25pt;margin-right:0in;margin-bottom:8.25pt;margin-left:0in">
<b><span lang="EN" style="color:#333333">Postdoctoral Fellow-CryoEM<o:p></o:p></span></b></p>
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<span lang="EN" style="font-size:12.0pt;color:#333333">Job ID: 1036368<o:p></o:p></span></p>
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<span lang="EN" style="font-size:12.0pt;color:#333333">Location: United States-Connecticut-Groton<o:p></o:p></span></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">Role Summary<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">The successful candidate will join the department of Groton Structural Biology and Biophysics (SB&B), a multidisciplinary group with established expertise in molecular biology,
protein biochemistry, biological mass spectrometry, proteomics, enzymology, NMR, biophysics and crystallography. Our mission is to provide integrated molecular insights into drug target mechanism and target-ligand interactions to promote discovery efforts
across multiple therapeutic areas, including Inflammation and Immunology, Neuroscience, Cardiovascular, Metabolic & Endocrine Diseases, Pain, Rare Diseases and Oncology.
<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">Within Pfizer, we have made a strong commitment to invest in single particle cryo-EM and have set up a state of the art microscope (Titan Krios) with a K2 direct electron detector
in newly renovated laboratory, a dedicated computer cluster and a TF20 microscope for screening samples.<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">As a Postdoctoral Fellow, you will have experience with structure determination by cryo-EM technology including sample preparation, data collection, data processing using state-of-art
software, and 3-D reconstruction. Ideally you will also be familiar with protein construct design, molecular biology and mutagenesis, protein expression, purification and biochemical/biophysical characterization of a membrane protein.<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">Equally important will be your ability to collaborate successfully with other scientists in the department and with biologists and chemists in multiple drug discovery teams. You
will eventually be expected to understand the critical issues and challenges faced by different drug discovery programs within Pfizer and design suitable experimental strategies based on cryo-EM technique that could positively impact the outcomes. SB&B is
part of Medicine Design group within Pfizer, with the overall goal of understanding the mode of action of lead compound using an integrated assessment of all aspects of protein-ligand interactions to drive drug discovery efforts.<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"> <o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b>Role Responsibilities<o:p></o:p></b></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">The Postdoctoral Fellow will design and perform experiments in the technical area of membrane protein purification, characterization and involved in single particle cryo-EM. Experimental
results will be formulated computationally and will be recorded in an electronic laboratory notebook.<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">Prompt and clear communication will occur with project team colleagues. External scientific publication and presentation will be encouraged when appropriate as a means of assuring
optimal research standards.<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><o:p> </o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto"><b>Qualifications<o:p></o:p></b></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">• You should have a PhD or be a PhD candidate (to be completed in 2016) in Biochemistry, Biophysics, Physics, Chemistry or a related field.<o:p></o:p></p>
<p class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto">• You should have the desire and experience to carry out single particle cryo-EM work with suitable independence, and have the creativity and drive to tackle scientific challenges.<o:p></o:p></p>
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<p class="MsoNormal"><o:p> </o:p></p>
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