<html><head><meta http-equiv="Content-Type" content="text/html charset=windows-1252"></head><body style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space;">A colleague spotted the link below: this paper discussed on the 3dem list last year has been retracted.<div><br><div><a href="http://retractionwatch.com/2015/08/06/brandeis-investigation-finds-scientific-misconduct-in-gold-nanoparticle-paper/">http://retractionwatch.com/2015/08/06/brandeis-investigation-finds-scientific-misconduct-in-gold-nanoparticle-paper/</a></div><div><br></div><div>John</div><div><br><div><div>On 26 Jun 2014, at 16:53, Stark, Holger <<a href="mailto:hstark1@gwdg.de">hstark1@gwdg.de</a>> wrote:</div><br class="Apple-interchange-newline"><blockquote type="cite"><div lang="DE" link="blue" vlink="purple" style="font-family: Helvetica; font-size: 12px; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: auto; text-align: start; text-indent: 0px; text-transform: none; white-space: normal; widows: auto; word-spacing: 0px; -webkit-text-stroke-width: 0px;"><div class="WordSection1" style="page: WordSection1;"><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(31, 73, 125);">Dear Grant,<o:p></o:p></span></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(31, 73, 125);"> </span></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span lang="EN-US" style="font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(31, 73, 125);">I had a closer look at the images and it turns out that the plus minus Au images have been created simply by rotating one image with respect to the other by 90 degrees and shifting the area of the image. I have attached an image that shows the remaining overlapping region after the rotation and shift (approximately).<o:p></o:p></span></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span lang="EN-US" style="font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(31, 73, 125);"> </span></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span lang="EN-US" style="font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(31, 73, 125);">Best regards<o:p></o:p></span></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span lang="EN-US" style="font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(31, 73, 125);">Holger<o:p></o:p></span></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span lang="EN-US" style="font-size: 11pt; font-family: Calibri, sans-serif; color: rgb(31, 73, 125);"> </span></div><div><div style="border-style: solid none none; border-top-color: rgb(181, 196, 223); border-top-width: 1pt; padding: 3pt 0cm 0cm;"><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><b><span lang="EN-US" style="font-size: 10pt; font-family: Tahoma, sans-serif;">From:</span></b><span lang="EN-US" style="font-size: 10pt; font-family: Tahoma, sans-serif;"><span class="Apple-converted-space"> </span><a href="mailto:3dem-bounces@ncmir.ucsd.edu" style="color: purple; text-decoration: underline;">3dem-bounces@ncmir.ucsd.edu</a><span class="Apple-converted-space"> </span>[<a href="mailto:3dem-bounces@ncmir.ucsd.edu" style="color: purple; text-decoration: underline;">mailto:3dem-bounces@ncmir.ucsd.edu</a>]<span class="Apple-converted-space"> </span><b>On Behalf Of<span class="Apple-converted-space"> </span></b>Jensen, Grant J.<br><b>Sent:</b><span class="Apple-converted-space"> </span>Mittwoch, 11. Juni 2014 03:25<br><b>To:</b><span class="Apple-converted-space"> </span><a href="mailto:3dem@ncmir.ucsd.edu" style="color: purple; text-decoration: underline;">3dem@ncmir.ucsd.edu</a><br><b>Subject:</b><span class="Apple-converted-space"> </span>[3dem] problematic paper about gold nano particle labeling just published in Structure<o:p></o:p></span></div></div></div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><o:p> </o:p></div><div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">Dear colleagues,<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"> </span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">bad news: a post-doc in my lab called my attention to a figure in a paper published recently in Structure that appears to be fraudulent. <o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"> </span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">It is Figure 3 of <o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"> </span></div></div><div><div id="S0969-2126(14)00016-1-title"><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"><a href="http://www.cell.com/structure/abstract/S0969-2126%2814%2900016-1" style="color: purple; text-decoration: underline;">High-Affinity Gold Nanoparticle Pin to Label and Localize Histidine-Tagged Protein in Macromolecular Assemblies</a><o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">Kelsey C. Anthony, Changjiang You, Jacob Piehler, Daniel A. Pomeranz Krummel<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span class="journaltitlesp"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">Structure</span></span><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">,<span class="Apple-converted-space"> </span><span class="issuevolsp">Vol. 22</span>,<span class="Apple-converted-space"> </span><span class="issuenumsp">Issue 4</span>,<span class="Apple-converted-space"> </span><span class="pagerange">p628–635</span><o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">Published online: February 20, 2014<o:p></o:p></span></div></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"> </span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">It appears that parts of one image have been duplicated and cut and pasted into other images, with “gold” particles added (photoshopped?) on top. If you’d like to judge for yourself, please see the two slides I’ve attached. Note how the background noise spots marked with the black arrows match, as do the noise spots marked with the red arrows, and note the strange square box around the particle marked with the blue arrow. In the bottom, I have captured a screen shot of the particle marked with my star on the upper left corner and cut and paste it next to the two particles supposedly “decorated” with gold fiducials on the right, but notice how all three particles seem to be identical. Even the noise around the particles match.<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"> </span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">We alerted the journal editors a few weeks ago, but as it now appears that their process to deal with this could be long, we wanted to alert the community too before anyone lost time pondering this new “method”. <o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"> </span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">Grant<o:p></o:p></span></div></div></div><div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"> </span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"> </span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">--------------------------------------------------------------------------<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">Grant Jensen<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">Professor of Biology and Investigator, HHMI<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">California Institute of Technology, Mail code 114-96<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">1200 E. California Blvd.<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">Pasadena, CA 91125<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">626-395-8827 (phone)<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">626-395-5730 (fax)<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"><a href="http://jensenatcaltech.edu/" style="color: purple; text-decoration: underline;">JensenATcaltech.edu</a><o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"><a href="http://www.jensenlab.caltech.edu/" style="color: purple; text-decoration: underline;">http://www.jensenlab.caltech.edu</a><o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">office location: 359 Broad (northwest corner of campus)<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"> </span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">Administrative Assistant Karin Mallard<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">626-395-8893 (phone)<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"><a href="http://kmallardatcaltech.edu/" style="color: purple; text-decoration: underline;">kmallardATcaltech.edu</a><o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;">--------------------------------------------------------------------------<o:p></o:p></span></div></div><div><div style="margin: 0cm 0cm 0.0001pt; font-size: 12pt; font-family: 'Times New Roman', serif;"><span style="font-size: 10.5pt; font-family: Calibri, sans-serif;"> </span></div></div></div></div><span><simple_rotation.jpg></span>_______________________________________________<br>3dem mailing list<br><a href="mailto:3dem@ncmir.ucsd.edu" style="color: purple; text-decoration: underline;">3dem@ncmir.ucsd.edu</a><br><a href="https://mail.ncmir.ucsd.edu/mailman/listinfo/3dem" style="color: purple; text-decoration: underline;">https://mail.ncmir.ucsd.edu/mailman/listinfo/3dem</a><br></div></blockquote></div><br><div apple-content-edited="true">
<span class="Apple-style-span" style="border-collapse: separate; border-spacing: 0px;"><span class="Apple-style-span" style="border-collapse: separate; color: rgb(0, 0, 0); font-family: Helvetica; font-style: normal; font-variant: normal; font-weight: normal; letter-spacing: normal; line-height: normal; orphans: 2; text-align: -webkit-auto; text-indent: 0px; text-transform: none; white-space: normal; widows: 2; word-spacing: 0px; -webkit-border-horizontal-spacing: 0px; -webkit-border-vertical-spacing: 0px; -webkit-text-decorations-in-effect: none; -webkit-text-size-adjust: auto; -webkit-text-stroke-width: 0px; "><div style="word-wrap: break-word; -webkit-nbsp-mode: space; -webkit-line-break: after-white-space; "><div><a href="mailto:briggs@embl.de"><br class="Apple-interchange-newline">john.briggs@embl.de</a><br>Tel. +49 6221 387 8482<br><br>Dr. John A. G. Briggs<br>European Molecular Biology Laboratory<br>Meyerhofstr. 1<br>69117 Heidelberg<br>Germany</div><div><br></div></div></span><br class="Apple-interchange-newline"><br class="Apple-interchange-newline"></span>
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