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<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><span lang="EN-GB">The Department of Molecular Biology at the Leiden University Medical Centre is looking for a:<o:p></o:p></span></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><b><span lang="EN-GB"> </span></b></p>
<p class="MsoNormal" style="margin-bottom:0cm;margin-bottom:.0001pt"><b><span lang="EN-GB" style="font-size:16.0pt;
line-height:115%">Post-doctoral researcher in cryo-electron tomography (1,0 fte)<o:p></o:p></span></b></p>
<p class="MsoPlainText" style="text-align:justify;line-height:115%"><span lang="EN-GB" style="mso-bidi-font-size:11.0pt;line-height:115%;mso-bidi-font-family:
"Times New Roman""> </span></p>
<p class="MsoPlainText" style="text-align:justify;line-height:115%"><span lang="EN-GB" style="mso-bidi-font-size:11.0pt;line-height:115%">A 2-year post-doc position is available for an electron microscopist with experience in cryo-electron tomography and sub-tomogram
averaging working on the structure of antibodies on antigenic surfaces, which follow our earlier work (Diebolder et al.,
</span>Science (2014) 343 (6176)). The research will cover all aspects of structure determination by cryo-electron tomography including sample preparation, data collection, data processing - including tilt series reconstructions and sub-tomogram averaging -
and 3D visualization.<b><o:p></o:p></b></p>
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<b>Function Description</b><span lang="EN-GB"><o:p></o:p></span></p>
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<o:p> </o:p></p>
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The candidate should have a Ph.D. or equivalent in Biology, Chemistry, Physics or related fields. The ideal candidate has over 3 years experience in cryo-EM. Advantageous would be previous practical experience with liposome systems and antibodies. Important
will be your ability to work project oriented and precise and collaborate successfully with other scientists. Good communication skills and knowledge of English are required.<o:p></o:p></p>
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<o:p> </o:p></p>
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<b><span lang="EN-GB">LUMC and Genmab<o:p></o:p></span></b></p>
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<o:p> </o:p></p>
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The successful candidate will join the Department of Molecular Cell Biology at the Leiden University Medical Center (LUMC) in Leiden, the Netherlands (https://electronmicroscopy.lumc.nl/index.html). Part of the work will be performed at the Netherlands Center
for Electron Nanoscopy (NeCEN) in Leiden (www.necen.nl). This state of the art facility is equipped with two Titan Krios microscopes with phase plate, energy filter, Cs corrector and K2 and/or Falcon II direct electron detectors. The work is a collaboration
with Genmab, a biotechnology company that is specialized in the creation and development of human antibody therapeutics for the treatment of cancer, located in Utrecht, the Netherlands (http://www.genmab.com/).<o:p></o:p></p>
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<o:p> </o:p></p>
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<b>Salary<o:p></o:p></b></p>
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<span lang="EN-GB"><o:p></o:p></span></p>
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<span lang="EN-GB">Salary will be based on past experience of the candidate, with a maximum of 4073 euro per month. Initially the position will be funded for 2 years, with possibility of extension.<o:p></o:p></span></p>
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<span lang="EN-GB"> </span></p>
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<span lang="EN-GB">Candidates should contact Dr. Roman Koning (<a href="mailto:r.i.koning@lumc.nl">r.i.koning@lumc.nl</a>) or Prof. Dr. Ir. Bram Koster (<a href="mailto:a.j.koster@lumc.nl">a.j.koster@lumc.nl</a>) and should include a CV, short statement of
accomplishments and electron microscopy skills, research interests, and contact information for at least two references. This call for candidates will close August 31, 2015.<o:p></o:p></span></p>
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<span lang="EN-GB"><br>
</span></p>
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<span lang="EN-GB"><br>
</span></p>
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<span lang="EN-GB"><br>
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<p class="MsoNormal" align="center" style="margin-bottom: 0.0001pt; font-family: Calibri, sans-serif; line-height: normal; text-align: center;">
<b><span lang="EN-US" style="font-size: 10pt; font-family: Arial, sans-serif; color: gray;">Dr. R.I.Koning (Roman)<o:p></o:p></span></b></p>
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<span lang="EN-US" style="font-size: 8pt; color: gray;"> </span></p>
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<span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;">Department of Cell Biology, Leiden University Medical Center</span><span lang="EN-US" style="font-size: 8pt; color: gray;"><o:p></o:p></span></p>
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<span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;">Postal Zone S1-P, P.O.Box 9600, 2300 RC Leiden, The Netherlands<o:p></o:p></span></p>
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<b><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;">visiting address</span></b><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;">:</span><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;"> Einthovenweg
20, Building 2, zone S1-P, room R-90-20<o:p></o:p></span></p>
<p class="MsoNormal" align="center" style="margin-bottom: 0.0001pt; font-family: Calibri, sans-serif; line-height: normal; text-align: center;">
<b><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;">tel.</span></b><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;"> (31) 71 526 9296 <b>fax.</b> (+31) 71 526 8270 <b>mail.</b> <a href="mailto:r.i.koning@lumc.nl">r.i.koning@lumc.nl</a> <b>web.</b> electronmicroscopy.lumc.nl</span><span lang="EN-US" style="font-size: 8pt; font-family: 'Times New Roman', serif; color: gray;"><o:p></o:p></span></p>
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<span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;"> </span></p>
<p class="MsoNormal" align="center" style="margin-bottom: 0.0001pt; font-family: Calibri, sans-serif; line-height: normal; text-align: center;">
<span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;">Netherlands Centre for Electron Nanoscopy, Institute Biology Leiden, Leiden University<o:p></o:p></span></p>
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<b><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;">visiting address:</span></b><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;"> Einsteinweg 55, 2333 RC Leiden, The Netherlands,
room 05.11<o:p></o:p></span></p>
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<b><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;">tel.</span></b><span lang="EN-US" style="font-size: 8pt; font-family: Arial, sans-serif; color: gray;"> (31) 71 527 1423 <b>mail.</b> <a href="mailto:r.i.koning@biology.leidenuniv.nl">r.i.koning@biology.leidenuniv.nl</a> <b>web.</b> www.necen.nl</span></p>
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