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<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Leidos Biomedical Research, Inc. (LBRI), a wholly owned subsidiary of Leidos, operates the Frederick National Laboratory for Cancer Research (FNLCR). FNLCR is a Federally Funded
Research and Development Center (FFRDC) sponsored by the National Cancer Institute (NCI). It is the only FFRDC dedicated to biomedical research. Through its status as an FFRDC, FNLCR provides NCI and others with a unique national resource to accelerate the
development and delivery of effective preventive, diagnostic, and therapeutic products for cancer and AIDS.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif""> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">The breadth of FNLCR’s activities spans the research and development spectrum, including investigator-initiated, hypothesis-driven research into cancer and AIDS; advanced technology
programs focused on genetics and genomics, proteins and proteomics, imaging, nanotechnology, bioinformatics, and laboratory animal sciences; clinical operations in support of NCI and National Institute of Allergy and Infectious Diseases (NIAID)-sponsored clinical
trials, as well as NCI drug discovery and development efforts; and management and operations of biopharmaceutical development and manufacturing programs under current Good Manufacturing Practice conditions for NCI and NIAID. Administrative, procurement, financial,
safety, and facilities support is provided to these R&D activities through state-of-the-art business processes. LBRI has approximately 1,900 employees and manages an annual operating budget of approximately $450M.
<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif""> <o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">For more information about Leidos Biomedical Research Inc., please visit our webpage at
<a href="http://www.leidosbiomed.com/">www.leidosbiomed.com</a>.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">PROGRAM DESCRIPTION</span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><br>
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the
external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which
performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding
reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">JOB DESCRIPTION</span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><br>
The Scientist I will perform: 1) negative staining and cryo-EM of proteins and protein complexes with biological sample preparation and imaging by traditional transmission electron microscopy (TEM) and scanning electron microscopy (SEM), 2) image analysis and
three-dimensional reconstructions on data from negative stained specimens, cryo-electron microscopy, and electron tomography, 3) sample preparation for electron microscopy studies (negative staining, SEM, room temperature plastic embedding, cryo-electron microscopy),
4) operation of electron microscopes (SEM and TEM) and cryogenic instrumentation, 5) image analysis and three dimensional reconstructions of electron microscopy data, and 6) segmentation, interpretation and presentation of two-dimensional averages and three-dimensional
volume data and fitting of high resolution data into electron density maps.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><br>
<b>BASIC QUALIFICATIONS</b><o:p></o:p></span></p>
<ul type="disc">
<li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Possession of Doctoral degree from an accredited college or university in a field related to Computational Science, Physics, Biology or Chemistry, or eight (8) years related experience in lieu
of degree<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Foreign degrees must be evaluated for U.S. equivalency<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Proficiency in biological and/or material sample preparation for electron microscopy<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Proficiency in the use and maintenance of transmission electron microscopes and scanning electron microscopes<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Strong analytical skills and ability to effectively communicate scientific results<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l0 level1 lfo1">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Experience with computational image analysis of electron microscopy data (e.g. Relion, Eman, Spider, Imagic, or similar)<o:p></o:p></span></li></ul>
<p class="MsoNormal"><b><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">PREFERRED QUALIFICATIONS</span></b><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p></o:p></span></p>
<ul type="disc">
<li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo2">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Experience with scripting or other programming skills<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo2">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Experience with cryogenic liquids<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo2">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Experience with maintenance of advanced instrumentation<o:p></o:p></span></li><li class="MsoNormal" style="mso-margin-top-alt:auto;mso-margin-bottom-alt:auto;mso-list:l1 level1 lfo2">
<span style="font-size:10.0pt;font-family:"Arial","sans-serif"">Experience with single particle reconstruction from negative stain and/or cryo-EM data<o:p></o:p></span></li></ul>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif"">To apply, please visit
</span><a href="http://jobs.leidos.com/ShowJob/Id/443761/Scientist-I-614205-%28NCI%29/">http://jobs.leidos.com/ShowJob/Id/443761/Scientist-I-614205-%28NCI%29/</a><o:p></o:p></p>
<p class="MsoNormal"><span style="font-size:10.0pt;font-family:"Arial","sans-serif""><o:p> </o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b><span style="color:#244061">Lauri Rimorin, PHR<o:p></o:p></span></b></p>
<p class="MsoNormal"><span style="color:#244061">Sr. Recruiter<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#7030A0">Leidos Biomedical Research, Inc.<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#244061">Frederick National Laboratory for Cancer Research<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#244061">P.O. Box B, Frederick, MD 21702<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#244061">Phone: 301-846-7324<o:p></o:p></span></p>
<p class="MsoNormal"><span style="color:#244061">Fax: 301-846-5172<br>
<a href="mailto:lauri.rimorin@nih.gov"><span style="color:blue">lauri.rimorin@nih.gov</span></a><o:p></o:p></span></p>
<p class="MsoNormal"><o:p> </o:p></p>
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