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<p class="MsoNormal"><span lang="EN-US" style="mso-ansi-language:EN-US">Post-doc position in cryo-EM single reconstruction at Utrecht University<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-ansi-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-ansi-language:EN-US">An immediate (3-year) post-doc position is available in the group of Piet Gros (Protein Crystallography, Bijvoet Center, Department of Chemistry, Faculty of Science, Utrecht University)
to work on membrane protein complexes of the immune system.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-ansi-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-ansi-language:EN-US">The lab has a long-standing record in structural biology of large human plasma-proteins, cell-surface receptors and protein complexes, in particular in the area of immunology and hematology.<span style="mso-spacerun:yes">
</span>We have extensive experience with and infrastructure for mammalian (soluble and membrane) protein expression, purification, characterization with biophysical methods and structure determination using X-ray crystallography. The university has recently
purchased an FEI Talos Arctica cryo-EM microscope and we have access to an FEI Titan Krios at NeCEN at Leiden University.
<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-ansi-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-ansi-language:EN-US">The post-doc position is available for 3 years and is part of the NWO funded Gravitation project to establish the Institute of Chemical Immunology.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-ansi-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span lang="EN-US" style="mso-ansi-language:EN-US">Further information:<o:p></o:p></span></b></p>
<p class="MsoNormal"><a href="http://www.uu.nl/staff/PGros/0"><span lang="EN-US" style="mso-ansi-language:EN-US">http://www.uu.nl/staff/PGros/0</span></a><span lang="EN-US" style="mso-ansi-language:EN-US"><o:p></o:p></span></p>
<p class="MsoNormal"><a href="http://www.crystal.chem.uu.nl/~gros/frontpage.php"><span lang="EN-US" style="mso-ansi-language:EN-US">http://www.crystal.chem.uu.nl/~gros/frontpage.php</span></a><span class="MsoHyperlink"><span lang="EN-US" style="mso-ansi-language:EN-US"><o:p></o:p></span></span></p>
<p class="MsoNormal"><a href="http://bijvoet-center.eu">http://bijvoet-center.eu</a><span class="MsoHyperlink">
</span><o:p></o:p></p>
<p class="MsoNormal"><o:p> </o:p></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span lang="EN-US" style="mso-ansi-language:EN-US">Embedding<o:p></o:p></span></b></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-ansi-language:EN-US">The Bijvoet Center for Biomolecular research includes strong research groups in structural biology, including X-ray crystallography, NMR and mass spectrometry, next to groups focusing on
glycobiology, membrane biology and protein folding.<span style="mso-spacerun:yes">
</span>At the Utrecht Science Park the Uithof, a strong network of Life Science researchers from Utrecht University, the University Medical Center Utrecht and the Hubrecht Institute interact throughout the disciplines of Chemistry, Biology, Pharmaceutical Sciences,
Physics, Veterinary Sciences and Medicine.<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-ansi-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><b style="mso-bidi-font-weight:normal"><span lang="EN-US" style="mso-ansi-language:EN-US">Requirements<o:p></o:p></span></b></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-ansi-language:EN-US">Applicants should have a PhD in Chemistry, Physics, Biology or related field.<span style="mso-spacerun:yes">
</span>A strong background in cryo-EM single-particle reconstruction is strongly preferred. Request for further information and applications containing a cover letter, CV and email addresses of two references should be send to Piet Gros (p.gros@uu.nl)<o:p></o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-ansi-language:EN-US"><o:p> </o:p></span></p>
<p class="MsoNormal"><span lang="EN-US" style="mso-ansi-language:EN-US"><o:p> </o:p></span></p>
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