<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.0 Transitional//EN"><HTML><HEAD><META HTTP-EQUIV="Content-Type" CONTENT="text/html; charset=utf-8"></HEAD><BODY><DIV>
<DIV class=Section1>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center; mso-layout-grid-align: none; mso-outline-level: 1"
align=center><B><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial">Facilities Manager in
Cryo-Electron Microscopy </SPAN></B><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial"><?xml:namespace prefix
= o ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center; mso-layout-grid-align: none"
align=center><B><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial"><o:p> </o:p></SPAN></B></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center; mso-layout-grid-align: none"
align=center><B><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial">Section of Structural
Biology, The <?xml:namespace prefix = st1 ns =
"urn:schemas-microsoft-com:office:smarttags" /><st1:place
w:st="on"><st1:PlaceType w:st="on">Institute</st1:PlaceType> of <st1:PlaceName
w:st="on">Cancer</st1:PlaceName></st1:place> Research </SPAN></B><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial"><o:p></o:p></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; TEXT-ALIGN: center; mso-layout-grid-align: none"
align=center><st1:City w:st="on"><B><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial">Chester</SPAN></B></st1:City><B><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial"> Beatty Laboratories,
<st1:City w:st="on">Chelsea</st1:City>, <st1:City w:st="on"><st1:place
w:st="on">London</st1:place></st1:City> </SPAN></B><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial"><o:p></o:p></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm -19.15pt 0pt 0cm; mso-layout-grid-align: none"><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial">The Section of
Structural Biology plays a key role in defining the structural basis for the
function of proteins and complexes implicated in cancer. As Facilities Manager
you will assist in setting up of the new cryo-electron microscopy facility for
structural studies on macromolecular protein complexes within the Section and
then be responsible its day to day running. The major focus of the work will be
data collection for structure determination by single particle methodology
alongside some electron crystallography and electron tomography studies. You
will be expected to collect data for a number of projects as well as participate
in the resulting image analysis. <o:p></o:p></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm -18pt 0pt 0cm; mso-layout-grid-align: none"><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial">The facility will be
fully equipped for cryo-EM studies including Tecnai F20 and Tecnai T12 electron
microscopes. An important aspect of the job will be to assist and enable
colleagues across The Institute and structural biologists at the CR-UK London
Research Institute to perform studies on proteins relevant to their own
experiments. <o:p></o:p></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none"><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial">Applicants should be
educated to degree or HNC/D level (a PhD would be desirable) and have a minimum
of 10 years post-qualification experience in a relevant field. This should
include experience in high resolution transmission electron microscopy,
preferably in the use of high voltage field emission instruments for
cryo-electron microscopy of biological macromolecules. Experience in single
particle image analysis would also be an advantage. <o:p></o:p></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none"><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial">The position is
available for a period of 5 years with a starting salary in the range £33,224 to
£37,443 p.a. inclusive, based on skills and previous experience.
<o:p></o:p></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none"><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial">Informal enquires may
be made to Dr E. Morris (Tel:+ 44 (0)20 7153 5531 / Email:
edward.morris@icr.ac.uk). <B>Please <U>DO NOT </U>send your application to Dr
Morris; CVs must be submitted in line with the instructions below.
</B><o:p></o:p></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none"><B><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial">To apply, please send
<U>two </U>copies of your CV including the names and addresses of <U>two
referees </U>to the HR Office, The <st1:place w:st="on"><st1:PlaceType
w:st="on">Institute</st1:PlaceType> of <st1:PlaceName w:st="on">Cancer
Research</st1:PlaceName></st1:place>, <st1:address w:st="on"><st1:Street
w:st="on">123 Old Brompton Road</st1:Street>, <st1:City
w:st="on">London</st1:City> <st1:PostalCode w:st="on">SW7
3RP</st1:PostalCode></st1:address> <U>quoting reference number CBL35</U>. For a
job description and person specification please visit our website at
</SPAN></B><B><U><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial; mso-bidi-font-size: 12.0pt">www.icr.ac.uk/jobs.html</SPAN></U></B><B><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial">. Alternatively you
may call our 24 hour recruitment line on 020 7153 5475. </SPAN></B><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial"><o:p></o:p></SPAN></P>
<P class=MsoNormal
style="MARGIN: 0cm 0cm 0pt; mso-layout-grid-align: none"><B><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial">Closing date:
</SPAN></B><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial">30<SUP><SPAN
style="POSITION: relative; TOP: -4pt; mso-text-raise: 4.0pt">th
</SPAN></SUP>June 2005 <o:p></o:p></SPAN></P></DIV><SPAN
style="FONT-SIZE: 11pt; COLOR: black; FONT-FAMILY: Arial; mso-fareast-font-family: 'Times New Roman'; mso-ansi-language: EN-GB; mso-fareast-language: EN-GB; mso-bidi-language: AR-SA"><BR
style="PAGE-BREAK-BEFORE: always; mso-break-type: section-break"
clear=all></SPAN></DIV></BODY></HTML>