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<P class=MsoTitle style="LINE-HEIGHT: normal"><FONT size=3><STRONG>The
Biophysical Discussions</STRONG></FONT></P>
<P class=MsoTitle style="LINE-HEIGHT: normal"> <?xml:namespace prefix = o
ns = "urn:schemas-microsoft-com:office:office" /><o:p></o:p></P>
<P align=center class=MsoNormal style="TEXT-ALIGN: center"><B
style="mso-bidi-font-weight: normal"><SPAN
style="FONT-SIZE: 16pt; mso-bidi-font-size: 10.0pt">Frontiers in Structural Cell
Biology:<o:p></o:p></SPAN></B></P>
<P align=center class=MsoNormal style="TEXT-ALIGN: center"><B
style="mso-bidi-font-weight: normal"><SPAN
style="FONT-SIZE: 16pt; mso-bidi-font-size: 10.0pt">How can we determine the
structures of large subcellular machines at atomic
resolution?<o:p></o:p></SPAN></B></P>
<P align=left class=MsoTitle
style="LINE-HEIGHT: normal; TEXT-ALIGN: left"> <o:p></o:p></P>
<H1 style="LINE-HEIGHT: normal"><FONT size=2><SPAN
style="mso-bidi-font-weight: bold">
Wine and Cheese
Reception: Friday 8:00 pm, April 19, 2001<o:p></o:p></SPAN></FONT></H1>
<H1 style="LINE-HEIGHT: normal"><FONT size=2>
Sessions Begin: Saturday 9:00 am, April 20,
2001</FONT></H1>
<P align=center class=MsoNormal style="TEXT-ALIGN: center"><B
style="mso-bidi-font-weight: normal">Sessions End: Monday 12:00 noon, April 22,
2001<o:p></o:p></B></P>
<P align=center class=MsoNormal style="TEXT-ALIGN: center"><B
style="mso-bidi-font-weight: normal"> <o:p></o:p></B></P>
<P align=center class=MsoNormal style="TEXT-ALIGN: center"><B
style="mso-bidi-font-weight: normal">Meeting site: Asilomar,
California<o:p></o:p></B></P>
<P align=center class=MsoNormal style="TEXT-ALIGN: center"><B
style="mso-bidi-font-weight: normal"> <o:p></o:p></B></P>
<P align=center class=MsoNormal style="TEXT-ALIGN: center"><B
style="mso-bidi-font-weight: normal">Organizing committee: Axel Brunger
(Stanford University), David DeRosier (Brandeis University), Steve Harrison
(Harvard University), and Eva Nogales (University of California at
Berkeley).</B></P>
<P class=MsoNormal> <o:p></o:p></P>
<P class=MsoNormal>The Biophysical Discussions will bring together a
wide-ranging group of scientists interested in extending and inventing methods
for determining, refining and verifying the atomic structures of cellular
machinery.<SPAN style="mso-spacerun: yes"> </SPAN>The emphasis of the
meeting is on discussion not formal presentations.<SPAN
style="mso-spacerun: yes"> </SPAN>The goal is to generate and explore new
ideas, to generate interest in pursuing them, and to forge new alliances to
bring these ideas to fruition.<SPAN style="mso-spacerun: yes"> </SPAN>The
emphasis will be on electron cryo-microscopy and x-ray crystallography.<SPAN
style="mso-spacerun: yes"> </SPAN>The space at the meeting is
limited.<SPAN style="mso-spacerun: yes"> </SPAN>The topics include:
the current state of affairs for studying big structures, prospects for ever
larger structures by x-ray crystallography, prospects for larger structures and
higher resolution by electron cryomicroscopy, new ways for producing specimens
of larger structures, and hybrid methods to achieve atomic resolution.<SPAN
style="mso-spacerun: yes"> </SPAN></P>
<P class=MsoNormal> <o:p></o:p></P>
<P class=MsoNormal>The presenters and discussion chairs include: Richard
Henderson (MRC-Laboratory of Molecular Biology), Jamie Cate (Whitehead
Institute-MIT), Ed Egelman (University of Virginia), Joachim Frank
(SUNY-Albany), Helen Saibil (Birkbeck College), Keith Hodgson (Stanford
University), Andy Thompson (EMBL-Grenoble), Janos Hajdu (Uppsala University),
Randy Read (University of Cambridge), Axel Brunger (Stanford University), Don
Wiley (Harvard University), Bob Glaeser (University of California at Berkeley),
Niko Grigorieff (Brandeis University), Ken Downing (Lawrence Berkeley
Laboratory, Wolfgang Baumeister (Max-Planck Institute-Martinsried), Eva Nogales
(University of California at Berkeley), Niels Volkmann (Burnham Institute), and
Willy Wriggers (Scripps Research Institute).</P>
<P class=MsoNormal> <o:p></o:p></P>
<P class=MsoNormal>Presenters at the meeting are preparing papers.<SPAN
style="mso-spacerun: yes"> </SPAN>These will be distributed to
participants for study so that presentation time is reduced (to 5-10 min) and
discussion is increased.<SPAN style="mso-spacerun: yes"> </SPAN>The entire
meeting will be taped and made available on the web.</P>
<P class=MsoNormal> <o:p></o:p></P>
<P class=MsoNormal>We ask that those interested in attending this meeting
apply.<SPAN style="mso-spacerun: yes"> </SPAN>As we may well have more
applications than there are spaces, we may need to restrict our
acceptances.<SPAN style="mso-spacerun: yes"> </SPAN>Applications can be
sent by email to derosier@biophysics.org. Please include Name, Address,
Affiliation, Title, and area of research interest.<SPAN
style="mso-spacerun: yes"> </SPAN>Posters are encouraged.<SPAN
style="mso-spacerun: yes"> </SPAN>If you wish to include a poster, please
send an abstract including title, authors, affiliations, and summary. (Abstracts
have a limit of 1420 characters in all – no figures, graphs etc. are
allowed.)<SPAN style="mso-spacerun: yes"> </SPAN>Deadline: November
15, 2001.<SPAN style="mso-spacerun: yes"> </SPAN>Registration fees and
room and board will be required from successful applicants.<SPAN
style="mso-spacerun: yes"> </SPAN>The registration fee for the meeting
will be $275.<SPAN style="mso-spacerun: yes"> </SPAN>Successful applicants
will be notified by December 15.</P>
<P class=MsoNormal> <o:p></o:p></P>
<P class=MsoNormal>At the meeting, some of the posters may be selected for short
oral presentations as happens for example at the CryoEM Gordon Conf.</P>
<P class=MsoNormal> <o:p></o:p></P>
<P class=MsoNormal> <o:p></o:p></P>
<P class=MsoNormal> <o:p></o:p></P>
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style="FONT-SIZE: 11pt; mso-bidi-font-size: 10.0pt"> <o:p></o:p></SPAN></P></FONT></DIV></BODY></HTML>